Pathogenic interactions between alcohol and hepatitis C

Current Gastroenterology Reports

Volumn 5, Issue 1, 2003, Pages 86-92

  Szabo, Gyongyi ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CORE PROTEIN; CYTOKINE; FAS ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANTIGEN PRESENTING CELL; APOPTOSIS; CLINICAL OBSERVATION; CYTOKINE PRODUCTION; DISEASE COURSE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INFLAMMATORY INFILTRATE; LIVER FIBROSIS; REVIEW; RISK FACTOR; T LYMPHOCYTE ACTIVATION; ALCOHOL LIVER DISEASE; DRUG EFFECT; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INNATE IMMUNITY; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; PATHOPHYSIOLOGY; PHYSIOLOGY; VIROLOGY;

CARCINOMA, HEPATOCELLULAR; DISEASE PROGRESSION; ETHANOL; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNE TOLERANCE; IMMUNITY, NATURAL; LIVER; LIVER DISEASES, ALCOHOLIC; LIVER NEOPLASMS;

EID: 0038621880     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-003-0014-x     Document Type: Review

References (50)

1. Liang JT, Rehermann D, Seeff LB, Hoofnagle JH: Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann Intern Med 2000, 132:296-305.
2. Schiff ER: The alcoholic patient with HCV infection. Am J Med 1999, 107:95S-99S.
3. Pessione F, Degos F, Marcellin P, et al.: Effect of alcohol consumption on serum hepatitis c virus RNA and histological lesions in chronic HCV. Hepatology 1998, 27:1717-1722.
4. Corrano G, Arico S: Independent and combined action of hepatitis c virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis. Hepatology 1998, 27:914-919.
5. Wiley T, McCarthy M, Breid L, et al.: Impact of alcohol on the histological and clinical progression of hepatitis C infection. Hepatology 1998, 28:805-809.
6. Vento S, Cainelli F: Does hepatitis C virus cause severe liver disease only in people who drink alcohol? Lancet Infect Dis 2002, 2:303-309.
7. Poynard T, Ratziu V, Charlotte F, et al.: Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C. J Hepatol 2001, 34:730-739.
8. Westin J, Lagging LM, Spak F, et al.: Moderate alcohol intake increases fibrosis progression in untreated patients with HCV infection. J Viral Hepat 2002, 9:235-241.
9. Cromie SL, Jenkins PJ, Bowden DS, Dudley FJ: Chronic hepatitis C: effect of alcohol on hepatic activity and viral titre. J Hepatol 1996, 25:821-826.
10. Levy L, Renard C, Wei Y, Buendia M: Genetic alterations and oncogenic pathways in hepatocellular carcinoma. Ann N Y Acad Sci 2002, 963:21-36.
11. Donato F, Tagger A, Gelatti U, et al.: Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 2002, 155:323-331.
12. Hellerbrand C, Hartmann A, Richter G, et al.: Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors. Dig Dis 2001, 19:345-351.
13. Freeman AJ, Marinos G, French R, Lloyd AR: Immunopathogenesis of hepatitis C infection. Immunol Cell Biol 2001, 79:515-536.
14. Tellinghousen TT, Rice CM: Interaction between hepatitis C virus protiens and host cell factors. Curr Opin Microbiol 2002, 5:419-429.
15. Koziel MJ: Cytokines in viral hepatitis. Semin Liver Dis 1999, 19:157-169.
16. Kanto T, Hayashi N, Takehara T, et al.: Impaired allostimulatory capacity of peripheral blood dendritic cells recovers from hepatitis C virus-infected individuals. J Immunol 1999, 162:5584-5591.
17. Auffermann-Gretzinger S, Keeffe EB, Levy S: Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 2001, 97:3171-3176.
18. Bain C, Fatmi A, Zoulim F, et al.: Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 2001, 120:512-524.
19. Lechner F, Wong DKH, Dunbar PR, et al.: Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000, 191:1499-1512.
20. Lechmann M, Woitas RP, Langhans B, et al.: Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C. J Hepatol 1999, 31:971-978.
21. Rehermann B, Chang K-M, McHutchinson JG, et al.: Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Ivest 1996, 98:1432-1440.
22. Lancaster T, Sanders E, Christie JML, et al.: Quantitative and functional differences in CD8+ lymphocyte responses in resolved and chronic hepatitis C virus infection. J Viral Hepat 2002, 9:18-28.
23. Cooper S, Erickson AL, Adams EJ, et al.: Analysis of a successful immune response against hepatitis C infection. Immunity 1999, 10:439-449.
24. Boisvert J, He X-S, Cheung R, et al.: Quantitative analysis of hepatitis C virus in peripheral blood and liver: replication detected only in liver. J Infect Dis 2001, 184:827-835.
25. Neuman MG, Benhamou J-P, Malkiewicz I, et al.: Cytokines as predictors for sustained response and as markers for immunomodulation in patients with chronic HCV. Clin Biochem 2001, 34:173-182.
26. Nelson DR, Lim HL, Marousis CG, et al.: Activation of tumor necrosis factor-alpha system in chronic hepatitis C infection. Dig Dis Sci 1997, 42:2487-2494.
27. Tseng C-T, Miskovsky E, Houghton M, Klimpel G: Characterizaion of liver T-cell receptor gd+ T cells obtained from individuals chronically infected with HCV. Hepatology 2001, 33:1312-1320.
28. Szabo G: Consequences of alcohol consumption on host defense. Alcohol Alcohol 1999, 43:830-841.
29. Cook RT: Alcohol abuse, alcoholism, and damage to the immune system: a review. Alcohol Clin Exp Res 1998, 22:1927-1942.
30. Peterson J, Vasquez K, Waltenbaugh C: IL-12 therapy restores cell-mediated immunity in ethanol consuming mice. Alcohol Clin Exp Res 1998, 22:245-251.
31. McClain C, Barve S, Deaciuc I, et al.: Cytokines in alcoholic liver disease. Semin Liver Dis 1999, 19:205-219.
32. Bautista AP: Impact of alcohol on the ability of Kupffer cells to produce chemokines and its role in alcoholic liver disease. J Gastroenterol Hepatol 2000, 15:349-356.
33. Pastorino JH and Hoek JB: Ethanol potentiates TNFa cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology 2000, 115:157-166.
34. Iimuro Y, Gallucci RM, Luster MI, et al.: Antibodies to TNFa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 1997, 26:1530-1537.
35. Yin M, Wheeler MD, Kono H, Thurman RG: Essential role for TNF in alcohol-induced liver injury in mice. Gastroenterology 1999, 117:942-952.
36. Friedman SL: Evaluation of fibrosis and HCV. Am J Med 1999, 107:27S-30S.
37. Toubi E, Kessel A, Goldstein I, et al.: Enhanced peripheral T-cell apoptosis in chronic hepatitis C virus infection: association with liver disease severity. J Hepatol 2001, 35:774-780.
38. Natori S, Rust C, Stadheim L, et al.: Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001, 34:248-253.
39. Schakel NA, McGuinness PH, Abbott CA, et al.: Insights into the pathobiology of HCV virus-associated cirrhosis. Am J Pathol 2002, 160:641-654.
40. Pianko S, Patella S, Ostapowicz G, et al.: Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. J Viral Hepat 2001, 8:406-413.
41. Galle MB, DeFranco RMS, Kerjaschki D, et al.: Ordered array of dendritic cells and CD8+ lymphocytes in portal infiltrates in chronic hepatitis C. Histopathology 2001, 39:373-381.
42. Jerrells T: Association of alcohol consumption and exaggerated immunopathologic effects in the liver induced by infectious organism. Front Biosci 2002, 7:1487-1493.
43. Tai DI, Tsai SL, Chen YM, et al.: Activation of nuclear factor kappaB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis. Hepatology 2000, 31:656-664.
44. Ghosh S and Karin M: Missing pieces in the NF-kappaB puzzle. Cell 2002, 109:S81-S96.
45. Szabo G, Catalano D, Bellerose G, Mandrekar P: IFNa and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and IFNa increases pro-inflammatory cytokine production. Alcohol Clin Exp Res 2001, 25:1188-1197.
46. Kim W, Hong F, Jagure B, et al.: Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein (HBX) or HCV core protein: involvement of TNFa receptor-1-independent and -dependent mechanisms. FASEB J 2001, 15:2551-2553.
47. Kato N, Yoshida H, Ono-Nita S, et al.: Activation of intracellular signaling by hepatitis B and C viruses: c-viral core is the most potent signal inducer. Hepatology 2000, 32:405-412.
48. Anand BS, Velez AM: Influence of chronic alcohol abuse on HCV virus replication. Dig Dis 2000, 18:168-171.
49. Takahashi K, Takahashi T, Takahashi S, et al.: Hepatitis C virus change by chronic alcohol intake. J Gastroenterol Hepatol 2001, 16:416-423.
50. Romero-Gomez M, Grande L, Nogales MC, et al.: Intrahepatic HCV replication is increased in patients with regular alcohol consumption. Dig Liver Dis 2001, 33:698-702.