Interleukin-12 therapy restores cell-mediated immunity in ethanol- consuming mice

Alcoholism: Clinical and Experimental Research

Volumn 22, Issue 1, 1998, Pages 245-251

  Peterson, Jeffrey D ^a   Vasquez, Kristine ^a   Waltenbaugh, Carl ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alcohol ingestion; BALB c mice; C57BL 6 mice; Cell mediated immunity; Interleukin 12

Indexed keywords

ALCOHOL; RECOMBINANT INTERLEUKIN 12;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; CELLULAR IMMUNITY; CONFERENCE PAPER; FEMALE; IMMUNOSTIMULATION; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MUS MUSCULUS;

EID: 0031887425     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1998.tb03645.x     Document Type: Conference Paper

References (31)

1. MacGregor RR: Alcohol and immune defense. JAMA 256:1474-1479, 1986
2. Mufti S, Prabhala R, Moriguchi S, Sipes IG, Watson RR: Functional and numerical alteration induced by ethanol in the cellular immune system. Immunopharmacology 15:85-94, 1988
3. Hoerner M, Behrens UJ, Worner T, Lieber CS: Humoral immune response to acetaldehyde adducts in alcoholic patients. Res Commun Chem Pathol Pharmacol 54:3-12, 1986
4. Paronetto F: Ethanol and the immune system, in Seitz HK, Kommerell B (eds): Alcohol Related Diseases in Gastroenterology. Berlin, Springer-Verlag, 1985, pp 269-281
5. Kaplan DR: A novel mechanism of immunosuppression mediated by ethanol. Cell Immunol 102:1-9, 1988
6. Roselle GA: Alcohol and the immune system. Alcohol Health Res World 16:16-22, 1992
7. Jayasinghe R, Gianutsos G, Hubbard AK: Ethanol-induced suppression of cell-mediated immunity in the mouse. Alcohol Clin Exp Res 16:331-335, 1992
8. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986
9. Macatonia SE, Hosken NA, Litton M, et al: Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154:5071-5079, 1995
10. Macatonia SE, Hsieh CS, Murphy KM, O'Garra A: Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int Immunol 5:1119-1128, 1993
11. Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol 12:227-257, 1994
12. Mosmann TR, Moore KW: The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol Today 12:49-53, 1991
13. Waltenbaugh C, Mikszta J, Ward H, Hsiung L: Alteration of copolymer-specific humoral and cell-mediated immune responses by ethanol. Alcohol Clin Exp Res 18:1-7, 1994
14. Schodde H, Hurst S, Munroe M, Barrett T, Waltenbaugh C: Ethanol ingestion inhibits cell-mediated immune responses of unprimed T-cell receptor transgenic mice. Alcohol Clin Exp Res 20:890-899, 1996
15. Mikszta JA, Waltenbaugh C, Kim BS: Impaired antigen presentation by splenocytes of ethanol-consuming C57BL/6 mice. Alcohol 12:265-271, 1995
16. Waltenbaugh C, Peterson JD: Ethanol impairs the induction of delayed hypersensitivity in C57BL/6 mice. Alcohol 14:149-157, 1997
17. Peterson JD, Herzenberg LA, Waltenbaugh C: Glutathione levels in antigen presenting cells determine Th1 versus Th2 response patterns. Proc Acad Natl Sci USA (in press)
18. Meadows GG, Blank SE, Duncan DD: Influence of ethanol consumption on natural killer cell activity in mice. Alcohol Clin Exp Res 13:476-479, 1989
19. Meadows GG, Blank SE, Duncan DA: Modulation of natural killer cell activity by alcohol consumption and nutritional status. Prog Clin Biol Res 325:181-190, 1990
20. Irwin MR, Caldwell C, Smith TL, Brown S, Schuckit MA, Gillin JC: Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Role of severity of depressive symptoms and alcohol consumption. Arch Gen Psychiatry 47:713-719, 1990
21. Trinchieri G: Interleukin-12 and its role in the generation of Th1 cells. Immunol Today 14:335-338, 1993
22. Trinchieri G, Wysocka M, D'Andrea A, Rengaraju M, Aste-Amezaga M, Kubin M, Valiante NM, Chehimi J: Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation. Prog Growth Factor Res 4:355-368, 1992
23. Waltenbaugh C, Miller SD: Common assays for identifying immune response genes, in Weir DM, Herzenberg LA, Blackwell C, Herzenberg LA (eds): Handbook of Experimental Immunology, vol 3. Boston, Blackwell Scientific Publications, 1986, pp 103.1-103.9
24. Fong TA, Mosmann TR: The role of IFN-γ in delayed-type hypersensitivity mediated by Th1 clones. J Immunol 143:2887-2893, 1989
25. Tripp CS, Gately MK, Hakimi J, Ling P, Unanue ER: Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-γ. J Immunol 152:1883-1887, 1994
26. Romagnani: The Th1/Th2 paradigm. Immunol Today 18:263-266, 1997
27. Saad AJ, Jerrells TR: Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcohol Clin Exp Res 15:796-803, 1991
28. Jerrells TR, Peritt D, Marietta C, Eckardt MJ: Mechanisms of suppression of cellular immunity induced by ethanol. Alcohol Clin Exp Res 13:490-493, 1989
29. Nabors GS, Farrell JP: Successful chemotherapy in experimental leishmaniasis is influenced by the polarity of the T cell response before treatment. J Infect Dis 173:979-986, 1996
30. Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF, Schaub RG: Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 177:1797-1802, 1993
31. Heinzel FP, Schoenhaut DS, Rerko RM, Rosser LE, Gately MK: Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 177:1505-1509, 1993