Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy

Archives of Toxicology

Volumn 77, Issue 4, 2003, Pages 218-226

  Debelle, Frédéric ^a   Nortier, Joëlle ^b   Arlt, Volker M ^c   De Prez, Eric ^a   Vienne, Anne ^b   Salmon, Isabelle ^b   Phillips, David H ^c   Deschodt Lanckman, Monique ^a   Vanherweghem, Jean Louis ^b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Aristolochic acid; Chinese herb nephropathy; Dexfenfluramine; DNA adducts; Renal fibrosis

Indexed keywords

ANOREXIGENIC AGENT; ARISTOLOCHIC ACID; CYTOSOL AMINOPEPTIDASE; DEXFENFLURAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHINESE HERB; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DNA ADDUCT; ENZYME ACTIVITY; ENZYMURIA; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY TUBULE DAMAGE; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA; ARISTOLOCHIA; RATTUS NORVEGICUS;

EID: 0038582622     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0438-y     Document Type: Article

References (41)

1. Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higernbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Begaud B (1996) Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group. N Engl J Med 335:609-616
2. Arlt VM, Wiessler M, Schmeiser HH (2000) Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene. Carcinogenesis 21:235-242
3. Arlt VM, Pfohl-Leszkowicz A, Cosyns J, Schmeiser HH (2001a) Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy. Mutat Res 494:143-150
4. Arlt VM, Schmeiser HH, Pfeifer GP (2001b) Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR. Carcinogenesis 22:133-140
5. Arlt VM, Stiborova M, Schmeiser HH (2002) Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Mutagenesis 17:265-277
6. Brenot F, Herve P, Petitpretz P, Parent F, Duroux P, Simonneau G (1993) Primary pulmonary hypertension and fenfluramine use. Br Heart J 70:537-541
7. Celada P, Martin F, Artigas F (1994) Effects of chronic treatment with dexfenfluramine on serotonin in rat blood, brain and lung tissue. Life Sci 55:1237-1243
8. Colson CR, De Greef KE, Duymelinck C, Simoens PJ, Verpooten GA, De Broe ME (1999) Role of serotonin in the development of Chinese herbs nephropathy? Nephrol Dial Transplant 14 [Suppl 4]: 16
9. Cosyns JP, Jadoul M, Squifflet JP, de Plaen JF, Ferluga D, Van Ypersele de Strihou (1994) Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int 45:1680-1688
10. Cosyns JP, Jadoul M, Squifflet JP, Wese FX, Van Ypersele de Strihou (1999) Urothelial lesions in Chinese-herb nephropathy. Am J Kidney Dis 33:1011-1017
11. Cosyns JP, Dehoux JP, Guiot Y, Goebbels RM, Robert A, Bernard AM, Van Ypersele de Strihou (2001) Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy? Kidney Int 59:2164-2173
12. De Broe ME (1999) On a nephrotoxic and carcinogenic slimming regimen. Am J Kidney Dis 33:1171-1173
13. Debelle FD, Nortier JL, de Prez EG, Garbar CH, Vienne AR, Salmon IJ, Deschodt-Lanckman MM, Vanherweghem JL (2002) Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol 13:431-436
14. Depierreux M, Van Damme B, Vanden Houte K, Vanherweghem JL (1994) Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs. Am J Kidney Dis 24:172-180
15. Eddahibi S, Raffestin B, Pham I, Launay JM, Aegerter P, Sitbon M, Adnot S (1997) Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats. Am J Physiol 272:H1173-H1181
16. Eddahibi S, Raffestin B, Launay JM, Sitbon M, Adnot S (1998) Effect of dexfenfluramine treatment in rats exposed to acute and chronic hypoxia. Am J Respir Crit Care Med 157:1111-1119
17. Epstein JI, Amin MB, Reuter VR, Mostofi FK (1998) The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol 22:1435-1448
18. 2A receptors. J Cell Physiol 175:341-347
19. Haritos VS, Ching MS, Ghabrial H, Gross AS, Taavitsainen P, Pelkonen O, Battaglia SE, Smallwood RA, Ahokas JT (1998) Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2. Pharmacogenetics 8:423-432
20. Joseph P, Xie T, Xu Y, Jaiswal AK (1994) NAD(P)H:quinone oxidoreductase 1 (DT-diaphorase): expression, regulation, and role in cancer. Oncol Res 6:525-532
21. Kabanda A, Jadoul M, Lauwerys R, Bernard A, Van Ypersele de Strihou (1995) Low molecular weight proteinuria in Chinese herbs nephropathy. Kidney Int 48:1571-1576
22. Lebeau C, Arlt VM, Schmeiser HH, Boom A, Verroust PJ, Devuyst O, Beauwens R (2001) Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells. Kidney Int 60:1332-1342
23. Malak J (1998) Chinese herb nephropathy is not a (dex)fenfluramine nephropathy but a serotonin nephropathy. J Altern Complement Med 4:131-132
24. Martinez MC, Nortier J, Vereerstraeten P, Vanherweghem JL (2002) Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose. Nephrol Dial Transplant 17:408-412
25. Murray SM (1979) The morphology of serotonin-induced renal lesions in the rat. J Pathol 128:203-211
26. Nortier JL, Deschodt-Lanckman MM, Simon S, Thielemans NO, de Prez EG, Depierreux MF, Tielemans CL, Richard C, Lauwerys RR, Bernard AM, Vanherweghem JL (1997) Proximal tubular injury in Chinese herbs nephropathy: monitoring by neutral endopeptidase enzymuria. Kidney Int 51:288-293
27. Nortier JL, Martinez MC, Schmeiser HH, Arlt VM, Bieler CA, Petein M, Depierreux MF, De Pauw L, Abramowicz D, Vereerstraeten P, Vanherweghem JL (2000) Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 342:1686-1692
28. Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D (2000) NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 129:77-97
29. Rowland NE, Carlton J (1988) Dexfenfluramine: effects on food intake in various animal models. Clin Neuropharmacol 11 [Suppl 1]:S33-S50
30. Schaaf GJ, de Groene EM, Maas RF, Commandeur JN, Fink-Gremmels J (2001) Characterization of biotransformation enzyme activities in primary rat proximal tubular cells. Chem Biol Interact 134:167-190
31. Schmeiser HH, Bieler CA, Wiessler M, Van Ypersele de Strihou, Cosyns JP (1996) Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 56:2025-2028
32. Schulz WA, Krummeck A, Rosinger I, Eickelmann P, Neuhaus C, Ebert T, Schmitz-Drager BJ, Sies H (1997) Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies. Pharmacogenetics 7:235-239
33. 32P-postlabelling analysis using different chromatographic procedures. Carcinogenesis 15:1187-1192
34. 32P-postlabeling analysis of DNA adduct formation. Mutat Res 493:149-160
35. Stiborova M, Frei E, Wiessler M, Schmeiser HH (2001b) Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2. Chem Res Toxicol 14:1128-1137
36. Stiborova M, Hajek M, Frei E, Schmeiser HH (2001c) Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH: cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy. Gen Physiol Biophys 20:375-392
37. Stiborova M, Frei E, Sopko B, Wiessler M, Schmeiser HH (2002) Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy. Carcinogenesis 23:617-625
38. Vanhaelen M, Vanhaelen-Fastre R, But P, Vanherweghem JL (1994) Identification of aristolochic acid in Chinese herbs. Lancet 343:174
39. Vanherweghem JL (2000) Nephropathy and herbal medicine. Am J Kidney Dis 35:330-332
40. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R (1993) Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 341:387-391
41. Xue GP, Fishlock RC, Snoswell AM (1988) Determination of creatinine in whole blood, plasma, and urine by high- performance liquid chromatography. Anal Biochem 171:135-140