E-cadherin involved in inactivation of WNT/β-catenin signalling in urothelial carcinoma and normal urothelial cells

British Journal of Cancer

Volumn 88, Issue 12, 2003, Pages 1932-1938

  Thievessen, I ^a,b   Seifert, H H ^a   Swiatkowski, S ^a   Florl, A R ^a   Schulz, W A ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

APC; Bladder cancer; CDHI; DNA methylation; TCF

Indexed keywords

BETA CATENIN; UVOMORULIN; WNT PROTEIN;

ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA METHYLATION; GENE MUTATION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; REPRESSOR GENE; TRANSCRIPTION REGULATION; UROGENITAL TRACT CANCER; UROTHELIUM;

BETA CATENIN; CADHERINS; CYTOSKELETAL PROTEINS; DNA METHYLATION; GENE EXPRESSION; GENES, APC; HUMANS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS; UROTHELIUM; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 0038574720     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601031     Document Type: Article

References (29)

1. Bornman DM, Mathew S, Alsruhe J, Herman JG, Gabrielson E (2001) Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals. Am J Pathol 159: 831 - 835
2. Brantjes H, Roose J, van De Wetering M, Clevers H (2001) All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res 29: 1410 - 1419
3. Bui TD, O'Brien T, Crew J, Cranston D, Harris AL (1998) High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer. Br J Cancer 77: 319 - 324
4. Carlsson P, Waterman ML, Jones KA (1993) The hLEF/TCF-1 α HMG protein contains a context-dependent transcriptional activation domain that induces the TCR α enhancer in T cells. Genes Dev 7: 2418 - 2430
5. Christoph F, Schmidt B, Schmitz-Dräger BJ, Schulz WA (1999) Over-expression and amplification of the c-myc gene in human urothelial carcinoma. Int J Cancer 84: 169 - 173
6. Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, Matrisian LM (1999) The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors. Oncogene 18: 2883 - 2891
7. Duval A, Rolland S, Tubacher E, Bui H, Thomas G, Hamelin R (2000) The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res 60: 3872 - 3879
8. Freeman MR, Yoo JJ, Raab G, Soker S, Adam RM, Schneck FX, Renshaw AA, Klagsbrun M, Atala A (1997) Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest 99: 1028 - 1036
9. Grimm MO, Jürgens B, Schulz WA, Decken K, Makri D, Schmitz-Dräger BJ (1995) Inactivation of tumor suppressor genes and deregulation of the c-myc gene in urothelial cancer cell lines. Urol Res 23: 293 - 300
10. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821 - 9826
11. Iwao K, Nakamori S, Kameyama M, Imaoka S, Kinoshita M, Fukui T, Ishiguro S, Nakamura Y, Miyoshi Y (1998) Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenamatous polyposis coli mutations. Cancer Res 58: 1021 - 1026
12. Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (1998) Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Gene 219: 101 - 110
13. Lin Y, Liu A, Zhang S, Ruusunen T, Kreidberg JA, Peltoketo H, Drummond I, Vainio S (2001) Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn 222: 26 - 39
14. Lipponen PK (1995) Expression of c-myc protein is related to cell proliferation and expression of growth factor receptors in transitional cell bladder cancer. J Pathol 175: 203 - 210
15. Maruyama R, Toyooka S, Toyooka KO, Harada K, Virmani AK, Zochbauer-Muller S, Farinas AJ, Vakar-Lopez F, Minna JD, Sagalowsky A, Czerniak B, Gazdar AF (2001) Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Cancer Res 61: 8659 - 8663
16. Polakis P (2000) Wnt signaling and cancer. Genes Dev 14: 1837 - 1851
17. Proctor AJ, Coombs LM, Cairns JP, Knowles MA (1991) Amplification at chromosome 11q13 in transitional cell tumours of the bladder. Oncogene 6: 789 - 795
18. Ribeiro-Filho LA, Franks J, Sasaki M, Shiina H, Li LC, Nojima D, Arap S, Carroll P, Enokida H, Nakagawa M, Yonezawa S, Dahiya R (2002) CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer. Mol Carcinog 34: 187 - 198
19. Rieger KM, Little AF, Swart JM, Kastrinakis WV, Fitzgerald JM, Hess DT, Libertino JA, Summerhayes IC (1995) Human bladder carcinoma cell lines as indicators of oncogenic change relevant to urothelial neoplastic progression. Br J Cancer 72: 683 - 690
20. Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H (1999) Synergy between tumor suppressor APC and the β-catenin-Tcf4 target Tcf1. Science 285: 1923 - 1926
21. Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destree O, Clevers H (1998) The Xenopus WNT effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395: 608 - 612
22. Schulz WA, Crawford N, Locker J (1988) Albumin and α-fetoprotein gene expression and DNA methylation in rat hepatoma cell lines. Exp Cell Res 174: 433 - 447
23. Southgate J, Hutton KAR, Thomas DFM, Trejdosiewicz LK (1994) Normal human urothelial cells in vitro: proliferation and induction of stratification. Lab Invest 71: 583 - 594
24. Steinhoff C, Prior A, Reichmann G, Seifert HH, Schulz WA (2002) Activity of E2F-dependent promoters in bladder carcinoma cells and their use for tumor-specific targeting of p53-induced apoptosis. Int J Oncol 21: 1033 - 1040
25. Stockinger A, Eger A, Wolf J, Beug H, Foisner R (2001) E-Cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 154: 1185 - 1196
26. Stoehr R, Krieg RC, Knuechel R, Hofstaedter F, Pilarsky C, Zaak D, Schmitt R, Hartmann A (2002) No evidence for involvement of beta-catenin and APC in urothelial carcinomas. Int J Oncol 20: 905 - 911
27. Swiatkowski S, Seifert HH, Steinhoff C, Thievessen I, Schliess F, Schulz WA (2003) Activities of MAP-kinase pathways in normal uroepithelial cells and uroepithelial carcinoma cell lines. Exp Cell Res 282: 48 - 57
28. Taipale J, Beachy PA (2001) The Hedgehog and Wnt signaling pathways in cancer. Nature 411: 349 - 354
29. Virmani AK, Rathi A, Sathyanarayana UG, Padar A, Huang CX, Cunnigham HT, Farinas AJ, Milchgrub S, Euhus DM, Gilcrease M, Herman J, Minna JD, Gazdar AF (2001) Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas. Clin Cancer Res 7: 1998 - 2004