Expression of nuclear receptors and apo E secretion during the differentiation of monocytic THP-1 cells into macrophages

Cell Biology and Toxicology

Volumn 19, Issue 2, 2003, Pages 95-105

  Perez, A ^a   Thuillard, J L ^a   Bentzen, C L ^a   Niesor, E J ^a,b  

^a ILEX Oncology Research   (Switzerland)

^b ILEX Oncology Research   (Switzerland)

Author keywords

Apolipoprotein E; Differentiation; Liver X receptor ; Macrophage; Nuclear receptor; THP 1 cell line

Indexed keywords

22 HYDROXYCHOLESTEROL; ALITRETINOIN; APOLIPOPROTEIN E; CALCITRIOL; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; LIVER X RECEPTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PIRINIXIC ACID; RECEPTOR; RETINOIC ACID; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SECRETION; RECEPTOR UPREGULATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

APOLIPOPROTEINS E; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MACROPHAGES; PHORBOL ESTERS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0038560954     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023307206125     Document Type: Article

References (49)

1. Auboeuf D, Rieusset J, Fajas L, et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes. 1997;46(8):1319-27.
2. Auwerx J. The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia. 1991;47(1):22-31.
3. Auwerx JH, Deeb S, Brunzell JD, Peng R, Chait A. Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines. Biochemistry. 1988;27(8):2651-5.
4. Basu SK, Ho YK, Brown MS, Bilheimer DW, Anderson RG, Goldstein JL. Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. J Biol Chem. 1982;257(16):9788-95.
5. 3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes. Leukemia. 1994;8(5):806-15.
6. Brown MS, Goldstein JL. Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. J Clin Invest. 1983;72(3):743-7.
7. Chawla A, Saez E, Evans RM. "Don't know much bile-ology. Cell. 2000;103(1):1-4.
8. Chawla A, Boisvert WA, Lee CH, et al. A PPARγ-LXR-ABCA pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001;7(1):161-71.
9. Chinetti G, Griglio S, Antonucci M, et al. Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J Biol Chem. 1998;273(40):25573-80.
10. Chinetti G, Lestavel S, Bocher V, et al. PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA pathway. Nat Med. 2001.7(1):53-8.
11. Choudhury A, Singh RK, Moniaux N, El Metwally TH, Aubert JP, Batra SK. Retinoic acid-dependent transforming growth factor-β2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-α signaling pathway. J Biol Chem. 2000;275(43): 33929-36.
12. Cutolo M, Villaggio B, Bisso A, Sulli A, Coviello D, Dayer JM. Presence of estrogen receptors in human myeloid monocytic cells (THP-1 cell line). Eur Cytokine Netw. 2001;12(2):368.
13. Defacque H, Sevilla C, Piquemal D, Rochette-Egly C, Marti J, Commes T. Potentiation of VD-induced monocytic leukemia cell differentiation by retinoids involves both RAR and RX R signaling pathways. Leukemia. 1997;11(2):221-7.
14. Dory L. Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages. J Lipid Res. 1991;32(5):783-92.
15. Edwards PA, Kast HR, Anisfeld AM. BAREing it all. The adoption of lxr and fxr and their roles in lipid homeostasis. J Lipid Res. 2002;43(1):2-12.
16. Galetto R, Albajar M, Polanco JI, Zakin MM, Rodriguez-Rey JC. Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region. Biochem J. 2001;357(Pt 2):521-7.
17. Gardiner EM, Baldock PA, Thomas GP, et al. Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. FASEB J. 2000;14(13):1908-16.
18. Giguere V. Orphan nuclear receptors: from gene to function. Endocr Rev. 1999;20(5):689-725.
19. Hanley K, Komuves LG, Ng DC, et al. Farnesol stimulates differentiation in epidermal keratinocytes via PPARα. J Biol Chem. 2000;275(15):11484-91.
20. Heyman RA, Mangelsdorf DJ, Dyck JA, et al. 9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor. Cell. 1992;68(2):397-406.
21. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature. 1996;383(6602):728-31.
22. Jansen J, Uitdehaag B, Koper JW, van Den Berg TK. Glucocorticoid receptor ligand binding in monocytic cells using a microplate assay. Pathobiology. 1999;67(5-6):262-4.
23. Kreutz M, Fritsche J, Ackermann U, Krause SW. Andreesen R. Retinoic acid inhibits monocyte to macrophage survival and differentiation. Blood. 1998;91(12):4796-802.
24. Laffitte BA, Repa JJ, Joseph SB, et al. LXRs control lipidinducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci USA. 2001;98(2):507-12.
25. Larkin L, Khachigian LM, Jessup W. Regulation of apolipoprotein E production in macrophages (review). Int J Mol Med. 2000;6(3):253-8.
26. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem. 1995;270(22): 12953-6.
27. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest. 1998; 102(5):1016-23.
28. Levin AA, Sturzenbecker LJ, Kazmer S, et al. 9-cis Retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature. 1992;355(6358):359-61.
29. Linton MF, Fazio S. Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies. Curr Opin Lipidol. 1999;10(2):97-105.
30. Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem. 2001;276(41):37735-8.
31. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988; 240(4852):622-30.
32. 3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J Cell Biol. 1984;98(2):391-8.
33. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade. Cell. 1995;83(6): 835-9.
34. Mazzone T. Apolipoprotein E secretion by macrophages: its potential physiological functions. Curr Opin Lipidol. 1996; 7(5):303-7.
35. Menju M, Tajima S, Yamamoto A. Expression of the apolipoprotein E gene in a human macrophage-like cell line, THP1. J Biochem (Tokyo). 1989;106(3):505-10.
36. Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci USA. 2001;98(9):5306-11.
37. Rees D, Sloane T, Jessup W, Dean RT, Kritharides L. Apolipoprotein A-I stimulates secretion of apolipoprotein E by foam cell macrophages. J Biol Chem. 1999;274(39):27925-33.
38. Schultz JR, Tu H, Luk A, et al. Role of LXRs in control of lipogenesis. Genes Dev. 2000;14(22):2831-8.
39. Simpson DA, Feeney S, Boyle C, Stitt AW. Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR. Mol Vis. 2000;6(8):178-83.
40. Staels B, Koenig W, Habib A, et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature. 1998;393(6687):790-3.
41. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93(2):241-52.
42. Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer. 1980;26(2):171-6.
43. Tsuchiya S, Kobayashi Y, Goto Y, et al. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res. 1982;42(4):1530-6.
44. Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem. 2000;275(19):14700-7.
45. von Eckardstein A, Nofer JR, Assmann G. High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler Thromb Vasc Biol. 2001;21(1):13-27.
46. Vosper H, Patel L, Graham TL, et al. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages. J Biol Chem. 2001;276(47):44258-65.
47. Werb Z, Chin JR. Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes. J Cell Biol. 1983;97(4):1113-18.
48. Zhu L, Gong B, Bisgaier CL, Aviram M, Newton RS. Induction of PPARγ1 expression in human THP-1 monocytic leukemia cells by 9-cis-retinoic acid is associated with cellular growth suppression. Biochem Biophys Res Commun. 1998;251(3):842-8.
49. 3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells. Cancer Res. 2000; 60(3):672-8.