The Ran GTPase: Theme and variations

Current Biology

Volumn 12, Issue 14, 2002, Pages

  Dasso, Mary ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BIOLOGICAL TRANSPORT; CELL CYCLE; CELL NUCLEUS; MITOTIC SPINDLE APPARATUS; RAN GTP-BINDING PROTEIN; ANIMALS;

VERTEBRATA;

RAN PROTEIN;

ANIMAL; CELL CYCLE; CELL NUCLEUS; METABOLISM; MITOSIS SPINDLE; PHYSIOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

EID: 0037162398     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00970-3     Document Type: Review

References (48)

1. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
2. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport
3. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA
4. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
5. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
6. Visualization of a RanGTP gradient in interphase and mitotic Xenopus egg extracts
7. Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
8. Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts
9. Ran binds to chromatin by two distinct mechanisms
10. Ran localizes around the microtubule spindle in vivo during mitosis in drosophila embryos
11. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles
12. The Ran/TC4 GTPase-binding domain: Identification by expression cloning and characterization of a conserved sequence motif
13. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran- GTP binding protein RanBP1
14. Mutants in a yeast Ran binding protein are defective in nuclear transport
15. Ran-binding protein 3 links Crm1 to the Ran exchange factor RCC1
16. Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export
17. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates
18. NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex
19. A giant nucleopore protein that binds Ran/TC4
20. Nuclear transport: Randy couples
21. RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors
22. Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells In vivo
23. Transport into and out of the nucleus
24. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
25. Importin 13: A novel mediator of nuclear import and export
26. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
27. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Np13p
28. Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting
29. Systems analysis of Ran transport
30. Running on Ran: Nuclear transport and the mitotic spindle
31. Ran induces spindle assembly by reversing the inhibitory effect of importin on TPX2 activity
32. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly
33. Role of Importin-{beta} in coupling Ran to down-stream targets in microtubule assembly
34. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
35. Ran-GTP coordinates the regulation of microtubule nucleation and dynamics during mitotic spindle assembly
36. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities
37. A mammalian partner of inscuteable binds NuMA and regulates mitotic spindle organization
38. Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis
39. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo
40. GTP hydrolysis by Ran is required for nuclear envelope assembly
41. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
42. Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system
43. Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?
44. Role of Importin-beta in the control of nuclear envelope assembly by Ran
45. Two distinct classes of ran-binding sites on the nucleoporin nup-358
46. Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2
47. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
48. The nucleoporin RanBP2 has SUMO1 E3 ligase activity