-
1
-
-
0033915678
-
Recent developments in structure-based drug design
-
Klebe, G. (2000) Recent developments in structure-based drug design. J. Mol. Med. 78, 269-281
-
(2000)
J. Mol. Med.
, vol.78
, pp. 269-281
-
-
Klebe, G.1
-
2
-
-
0033915982
-
Recent developments in rational structure-based drug design
-
Gane, P.J. and Dean, P.M. (2000) Recent developments in rational structure-based drug design. Curr. Opin. Struct. Biol. 10, 401-404
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
, pp. 401-404
-
-
Gane, P.J.1
Dean, P.M.2
-
3
-
-
0003029784
-
Drug discovery in 3-D
-
Sawyer, T.K. (2001) Drug discovery in 3-D. Curr. Drug Discov. 6, 33-37
-
(2001)
Curr. Drug Discov.
, vol.6
, pp. 33-37
-
-
Sawyer, T.K.1
-
4
-
-
0035416072
-
Structural genomics: Opportunities and challenges
-
Mittl, P.R. and Grutter, M.G. (2001) Structural genomics: opportunities and challenges. Curr. Opin. Chem. Biol. 5, 402-408
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 402-408
-
-
Mittl, P.R.1
Grutter, M.G.2
-
5
-
-
0035919686
-
Industrializing structural biology
-
Stevens, R.C. and Wilson, I.A. (2001) Industrializing structural biology. Science 293, 519-520
-
(2001)
Science
, vol.293
, pp. 519-520
-
-
Stevens, R.C.1
Wilson, I.A.2
-
6
-
-
0033767941
-
New roles for structure in biology and drug discovery
-
Russell, R.B. and Eggleston, D.S. (2000) New roles for structure in biology and drug discovery. Nat. Struct. Biol. 7 (Suppl.), 928-930
-
(2000)
Nat. Struct. Biol.
, vol.7
, Issue.SUPPL.
, pp. 928-930
-
-
Russell, R.B.1
Eggleston, D.S.2
-
7
-
-
0033767363
-
Structural genomics for science and society
-
Hol, W.G. (2000) Structural genomics for science and society. Nat. Struct. Biol. 7 (Suppl.), 964-966
-
(2000)
Nat. Struct. Biol.
, vol.7
, Issue.SUPPL.
, pp. 964-966
-
-
Hol, W.G.1
-
8
-
-
0033773899
-
Discovering novel ligands for macromolecules using X-ray crystallographic screening
-
Nienaber, V.L. et al. (2000) Discovering novel ligands for macromolecules using X-ray crystallographic screening. Nat. Biotechnol. 18, 1105-1108
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 1105-1108
-
-
Nienaber, V.L.1
-
9
-
-
0036051992
-
High-throughput crystallography for lead discovery in drug design
-
Blundell, T.L. et al. (2002) High-throughput crystallography for lead discovery in drug design. Nat. Rev. Drug Discov. 1, 45-54
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 45-54
-
-
Blundell, T.L.1
-
10
-
-
0035358813
-
Applications of NMR in drug discovery
-
Diercks, T. et al. (2001) Applications of NMR in drug discovery. Curr. Opin. Chem. Biol. 5, 285-291
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 285-291
-
-
Diercks, T.1
-
11
-
-
0033954256
-
The Protein Data Bank
-
Berman, H.M. et al. (2000) The Protein Data Bank. Nucleic Acids Res. 28, 235-242
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
-
12
-
-
0035003352
-
3-D pharmacophores in drug discovery
-
Mason, J.S. et al. (2001) 3-D pharmacophores in drug discovery. Curr. Pharm. Des. 7, 567-597
-
(2001)
Curr. Pharm. Des.
, vol.7
, pp. 567-597
-
-
Mason, J.S.1
-
13
-
-
0036214750
-
Virtual screening: Methods, expectations, and reality
-
Bajorath, J. (2002) Virtual screening: methods, expectations, and reality. Curr. Drug Discov. 2, 24-28
-
(2002)
Curr. Drug Discov.
, vol.2
, pp. 24-28
-
-
Bajorath, J.1
-
14
-
-
0035416126
-
High-through put docking for lead generation
-
Abagyan, R. and Totrov, M. (2001) High-through put docking for lead generation. Curr. Opin. Chem. Biol. 5, 375-385
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 375-385
-
-
Abagyan, R.1
Totrov, M.2
-
15
-
-
0034994015
-
Cheminformatics: A tool for decision-makers in drug discovery
-
Olsson, T. and Oprea, T.I. (2001) Cheminformatics: a tool for decision-makers in drug discovery. Curr. Opin. Drug Discov. Devel. 4, 308-313
-
(2001)
Curr. Opin. Drug Discov. Devel.
, vol.4
, pp. 308-313
-
-
Olsson, T.1
Oprea, T.I.2
-
16
-
-
0036047069
-
Drug discovery by dynamic combinatorial libraries
-
Ramstrom, O. and Lehn, J-M. (2002) Drug discovery by dynamic combinatorial libraries. Nat. Rev. Drug Discov. 1, 26-36
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 26-36
-
-
Ramstrom, O.1
Lehn, J.-M.2
-
17
-
-
0036560521
-
Combinatorial informatics in the post-genomics era
-
Agrafiotis, D.K. et al. (2002) Combinatorial informatics in the post-genomics era. Nat. Rev. Drug Discov. 1, 337-346
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 337-346
-
-
Agrafiotis, D.K.1
-
18
-
-
0038259177
-
Structure-based library design: Molecular modeling merges with combinatorial chemistry
-
Bohm, H-J. and Stahl, M. (2000) Structure-based library design: molecular modeling merges with combinatorial chemistry. Curr. Opin. Chem. Biol. 4, 283-286
-
(2000)
Curr. Opin. Chem. Biol.
, vol.4
, pp. 283-286
-
-
Bohm, H.-J.1
Stahl, M.2
-
19
-
-
0035358567
-
Lead compounds discovered from libraries
-
Golebiowski, A. et al. (2001) Lead compounds discovered from libraries. Curr. Opin. Chem. Biol. 5, 273-284
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 273-284
-
-
Golebiowski, A.1
-
20
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber, S.L. (2000) Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 287, 1964-1969
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
21
-
-
0035415863
-
Chemogenomic approaches in drug discovery
-
Caron, P.R. et al. (2001) Chemogenomic approaches in drug discovery. Curr. Opin. Chem. Biol. 5, 464-470
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 464-470
-
-
Caron, P.R.1
-
22
-
-
0035953319
-
Property-based design: Optimization of drug absorption and pharmacokinetics
-
Van de Waterbeemd, H. et al. (2001) Property-based design: optimization of drug absorption and pharmacokinetics. J. Med. Chem. 44, 1313-1333
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1313-1333
-
-
Van De Waterbeemd, H.1
-
23
-
-
0035523085
-
The new pre-clinical paradigm: Compound optimization in early and late phase drug discovery
-
Caldwell, G.W. et al. (2001) The new pre-clinical paradigm: compound optimization in early and late phase drug discovery. Curr. Topics Med. Chem. 1, 353-366
-
(2001)
Curr. Topics Med. Chem.
, vol.1
, pp. 353-366
-
-
Caldwell, G.W.1
-
24
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinksi, C. et al. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3-25
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinksi, C.1
-
25
-
-
0036047564
-
Moving smaller in drug discovery and delivery
-
LaVan, D.A. et al. (2002) Moving smaller in drug discovery and delivery. Nat. Rev. Drug Discov. 1, 77-84
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 77-84
-
-
LaVan, D.A.1
-
26
-
-
0034677755
-
Mechanism-based target identification and drug discovery in cancer research
-
Gibbs, J.B. (2000) Mechanism-based target identification and drug discovery in cancer research. Science 287, 1969-1973
-
(2000)
Science
, vol.287
, pp. 1969-1973
-
-
Gibbs, J.B.1
-
27
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drews, J. (2000) Drug discovery: a historical perspective. Science 287, 1960-1964
-
(2000)
Science
, vol.287
, pp. 1960-1964
-
-
Drews, J.1
|