Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic acid-induced glutathione transferase zeta deficiency

Toxicological Sciences

Volumn 74, Issue 1, 2003, Pages 192-202

  Lantum, Hoffman B M ^a,b   Cornejo, Judith ^a   Pierce, Robert H ^a   Anders, M W ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b EASTMAN KODAK COMPANY   (United States)

Author keywords

haloalkanoic acid; aminolevulinic acid dehydratase; Dichloroacetic acid; Glutathione transferase zeta; Lactic acidosis; Maleylacetoacetic acid; Maleylacetone; Succinylacetone; Tyrosinemia

Indexed keywords

ACETOACETIC ACID DERIVATIVE; BIOLOGICAL MARKER; DICHLOROACETIC ACID; GLUTATHIONE TRANSFERASE; HOMOGENTISIC ACID; PORPHOBILINOGEN SYNTHASE; SUCCINYLACETONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TOXICITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INACTIVATION; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MALE; MASS SPECTROMETRY; MEDIATOR; NEPHROTOXICITY; NONHUMAN; RAT; TYROSINEMIA; URINALYSIS;

ANIMALS; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, LIQUID; DICHLOROACETATE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE TRANSFERASE; KINETICS; LIVER; MALE; MALEATES; MICE; MICE, TRANSGENIC; PORPHOBILINOGEN SYNTHASE; RATS; RATS, INBRED F344; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

ANIMALIA;

EID: 0038493934     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg104     Document Type: Article

References (40)

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