Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1)

Chemical Research in Toxicology

Volumn 15, Issue 7, 2002, Pages 957-963

  Lantum, Hoffman B M ^a   Board, Philip G ^b   Anders, M W ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ACETONE; CHLOROFLUOROACETIC ACID; DEOXYCORTICOSTERONE ACETATE; ENZYME VARIANT; GLUTATHIONE TRANSFERASE; HALOACID; MALEYLACETOACETATE; MALEYLACETONE; META TYROSINE; UNCLASSIFIED DRUG; CIS TRANS ISOMERASE; DICHLOROACETIC ACID; DRUG DERIVATIVE; ENZYME INHIBITOR; GSTZ1 PROTEIN, HUMAN; MALEIC ACID DERIVATIVE; RECOMBINANT PROTEIN;

AMINO ACID METABOLISM; ARTICLE; BIOTRANSFORMATION; CATALYSIS; COMPETITIVE INHIBITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME POLYMORPHISM; INHIBITION KINETICS; NONHUMAN; TURNOVER TIME; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HUMAN; KINETICS; METABOLISM; PH; SINGLE NUCLEOTIDE POLYMORPHISM;

ACETIC ACIDS; ACETONE; BIOTRANSFORMATION; CIS-TRANS-ISOMERASES; DICHLOROACETATE; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; HUMAN; HYDROGEN-ION CONCENTRATION; KINETICS; MALEATES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; HUMANS;

CELL FUSING AGENT VIRUS;

EID: 0035996338     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx010095y     Document Type: Article

References (35)

1. Zeta, a novel class of glutathione transferases in a range of species from plants to humans
2. Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue
3. Maleylacetoacetate isomerase
4. Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid
5. Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other α-haloacids
6. Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis
7. The properties of maleylacetoacetate, the initial product of homogentisate oxidation in liver
8. The synthesis of model compounds for maleylacetoacetic acid: Maleylacetone
9. Enzymatic cis-trans isomerization of maleylpyruvic acid
10. cis-β-Acetylacrylate is a substrate for maleylacetoacetate cis-trans isomerase. Mechanistic implications
11. Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking α-haloalkanoic acids
12. Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetic acid
13. On the enzymic defects in hereditary tyrosinemia
14. Hypertyrosinemia
15. Mutations of the fumarylacetoacetate hydrolase gene in four patients with tyrosinemia, type I
16. Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity
17. Identification of 4,6-dioxoheptanoic acid (succinylacetone), 3,5-dioxooctanedioic acid (succinylacetoacetate) and 4-Oxo-6-hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia
18. Oral loading of homogentisic acid in controls and in obligate heterozygotes for hereditary tyrosinemia type I
19. Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: A potential unifying mechanism for its altered biotransformation and toxicity
20. The occurrence of disinfection byproducts in US drinking water
21. The pharmacology of dichloroacetate
22. The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice
23. Purification and properties of maleylacetone cis-trans isomerase from Vibrio O1
24. Recruitment of a double bond isomerase to serve as a reductive dehalogenase during biodegradation of pentachlorophenol
25. Patterns of enzyme inhibition
26. Alkylation and Inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone
27. Maleylacetone cis-trans-isomerase. Mechanism of the interaction of coenzyme glutathione and substrate maleylacetone in the presence and absence of enzyme
28. Degradation of homogentisate by strains of Bacillus and Moraxella
29. Glutathioneindependent maleylacetoacetate isomerase in Gram-positive bacteria
30. Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase
31. Homogentisate metabolism: The isomerization of maleylacetoacetate by an enzyme which requires glutathione
32. Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity
33. GSTZ1d: A new allele of glutathione transferase zeta and maleylacetoacetate isomerase
34. Structure, catalytic mechanism, and evolution of the glutathione transferases
35. Glutathione S-transferases - A review