Inhibition of glutathione S-transferase ζ and tyrosine metabolism by dichloroacetate: A potential unifying mechanism for its altered biotransformation and toxicity

Biochemical and Biophysical Research Communications

Volumn 262, Issue 3, 1999, Pages 752-756

  Cornett, Rachel ^a   James, Margaret O ^a   Henderson, George N ^b   Cheung, Jang ^b   Shroads, Albert L ^b   Stacpoole, Peter W ^b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOACETIC ACID; ACETONE; ALKYLATING AGENT; DICHLOROACETIC ACID; GLUTATHIONE TRANSFERASE; GLYOXYLIC ACID; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CELL METABOLISM; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION;

ANIMALIA; RODENTIA;

EID: 0033533466     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1999.1287     Document Type: Article

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