Mutational analyses of the p35-caspase interaction: A bowstring kinetic model of caspase inhibition by p35

Journal of Biological Chemistry

Volumn 278, Issue 7, 2003, Pages 5455-5461

  Xu, Guozhou ^a,c   Rich, Rebecca L ^b   Steegborn, Clemens ^a   Min, Tongpil ^a   Huang, Yihua ^a   Myszka, David G ^b   Wu, Hao ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSENSORS; CHEMICAL BONDS; CRYSTAL STRUCTURE; HYDROLYSIS; SURFACE PLASMON RESONANCE;

REACTIVE SITE LOOP (RSL);

ENZYME INHIBITION;

CASPASE; CASPASE 8; CYSTEINE; PROTEIN P35; CASP3 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE 3; CASPASE 9; ENZYME INHIBITOR; LIPOPROTEIN; OUTER MEMBRANE PROTEIN; P35 PROTEIN, BACULOVIRUS; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BACULOVIRUS; BIOSENSOR; CATALYSIS; CELL DESTRUCTION; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROLYSIS; KINETICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE;

UNIDENTIFIED BACULOVIRUS;

APOPTOSIS; BACTERIAL OUTER MEMBRANE PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; DNA MUTATIONAL ANALYSIS; ENZYME INHIBITORS; HUMANS; LIPOPROTEINS; MODELS, MOLECULAR; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

EID: 0038475942     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211607200     Document Type: Article

References (35)

1. Thompson, C. B. (1995) Science 267, 1456-1461
2. Johnstone, R. W., Ruefli, A. A., and Lowe, S. W. (2002) Cell 108, 153-164
3. Nicholson, D. W. (1999) Cell Death Differ. 6, 1028-1042
4. Stennicke, H. R., Renatus, M., Meldal, M., and Salvesen, G. S. (2000) Biochem. J. 350, 563-568
5. Ekert, P. G., Silke, J., and Vaux, D. L. (1999) Cell Death Differ. 6, 1081-1086
6. Stennicke, H. R., Ryan, C. A., and Salvesen, G. S. (2002) Trends Biochem. Sci. 27, 94-101
7. Bump, N. J., Hackett, M., Hugunin, M., Seshagiri, S., Brady, K., Chen, P., Ferenz, C., Franklin, S., Ghayur, T., Li, P., Mankovich, J., Shi, L. F., Greenburg, A. H., Miller, L. K., and Wong, W. W. (1995) Science 269, 1885-1888
8. Xue, D., and Horvitz, H. R. (1995) Nature 377, 248-251
9. Zhou, Q., Krebs, J. F., Snipas, S. J., Price, A., Alnemri, E. S., Tomaselli, K. J., and Salvesen, G. S. (1998) Biochemistry 37, 10757-10765
10. Araki, T., Shibata, M., Takano, R., Hisahara, S., Imamura, S., Fukuuchi, Y., Saruta, T., Okano, H., and Miura, M. (2000) Cell Death Differ. 7, 485-492
11. Beidler, D. R., Tewari, M., Friesen, P. D., Poirier, G., and Dixit, V. M. (1995) J. Biol. Chem. 270, 16526-16528
12. Clem, R. J., Fechheimer, M., and Miller, L. K. (1991) Science 254, 1388-1390
13. Datta, R., Kojima, H., Banach, D., Bump, N. J., Talanian, R. V., Alnemri, E. S., Weichselbaum, R. R., Wong, W. W., and Kufe, D. W. (1997) J. Biol. Chem. 272, 1965-1969
14. Hay, B. A., Wolff, T., and Rubin, G. M. (1994) Development (Camb.) 120, 2121-2129
15. Hisahara, S., Araki, T., Sugiyama, F., Yagami, K., Suzuki, M., Abe, K., Yamamura, K., Miyazaki, J., Momoi, T., Saruta, T., Bernard, C. C., Okano, H., and Miura, M. (2000) EMBO J. 19, 341-348
16. Martinou, I., Fernandez, P. A., Missotten, M., White, E., Allet, B., Sadoul, R., and Martinou, J. C. (1995) J. Cell Biol. 128, 201-208
17. Morishima, N., Okano, K., Shibata, T., and Maeda, S. (1998) FEBS Lett. 427, 144-148
18. Rabizadeh, S., LaCount, D. J., Friesen, P. D., and Bredesen, D. E. (1993) J. Neurochem. 61, 2318-2321
19. Robertson, N. M., Zangrilli, J., Fernandes-Alnemri, T., Friesen, P. D., Litwack, G., and Alnemri, E. S. (1997) Cancer Res. 57, 43-47
20. Sugimoto, A., Friesen, P. D., and Rothman, J. H. (1994) EMBO J. 13, 2023-2028
21. Fisher, A. J., Cruz, W., Zoog, S. J., Schneider, C. L., and Friesen, P. D. (1999) EMBO J. 18, 2031-2039
22. Xu, G., Cirilli, M., Huang, Y., Rich, R. L., Myszka, D. G., and Wu, H. (2001) Nature 410, 494-497
23. Myszka, D. G. (1999) J. Mol. Recognit. 12, 279-284
24. Myszka, D. G., and Morton, T. A. (1998) Trends Biochem. Sci. 23, 149-150
25. Park, Y. C., Ye, H., Hsia, C., Segal, D., Rich, R. L., Liou, H.-L., Myszka, D. G., and Wu, H. (2000) Cell 101, 777-787
26. Cunningham, B. C., and Wells, J. A. (1993) J. Mol. Biol. 234, 554-563
27. Eddins, M. J., Lemongello, D., Friesen, P. D., and Fisher, A. J. (2002) Acta Crystallogr. Sect. D Biol. Crystallogr. 58, 299-302
28. Snipas, S. J., Stennicke, H. R., Riedl, S., Potempa, J., Travis, J., Barrett, A. J., and Salvesen, G. S. (2001) Biochem. J. 357, 575-580
29. Bertin, J., Mendrysa, S. M., LaCount, D. J., Gaur, S., Krebs, J. F., Armstrong, R. C., Tomaselli, K. J., and Friesen, P. D. (1996) J. Virol. 70, 6251-6259
30. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
31. Zoog, S. J., Bertin, J., and Friesen, P. D. (1999) J. Biol. Chem. 274, 25995-26002
32. dela Cruz, W. P., Friesen, P. D., and Fisher, A. J. (2001) J. Biol. Chem. 276, 32933-32939
33. Wright, H. T., and Scarsdale, J. N. (1995) Proteins 22, 210-225
34. Engh, R. A., Huber, R., Bode, W., and Schulze, A. J. (1995) Trends Biotechnol. 13,503-510
35. Huntington, J. A., Read, R. J., and Carrell, R. W. (2000) Nature 407, 923-926