Inhibition of distant caspase homologues by natural caspase inhibitors

Biochemical Journal

Volumn 357, Issue 2, 2001, Pages 575-580

  Snipas, S J ^a   Stennicke, H R ^a   Riedl, S ^a   Potempa, J ^a   Travis, J ^a   Barrett, A J ^a   Salvesen, G S ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Gingipain; Inhibitory mechanism; Proteases

Indexed keywords

BACTERIA; CELLS; ENZYMES; MUTAGENESIS; VIRUSES;

CASPASES;

BIOCHEMISTRY;

ASPARTIC ACID; CASPASE INHIBITOR; CLOSTRIPAIN; CYSTEINE PROTEINASE; CYTOKINE; CYTOKINE RESPONSE MODIFIER A; GINGIPAIN K; GINGIPAIN R; LYSINE; PROTEIN P35; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOGRAPHA CALIFORNICA; CARBOXY TERMINAL SEQUENCE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SPECIFICITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FAMILY;

AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; CASPASES; CLONING, MOLECULAR; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEOPOLYHEDROVIRUS; PLANT PROTEINS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SERPINS; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

ANIMALIA; AUTOGRAPHA CALIFORNICA; BACTERIA (MICROORGANISMS); UNIDENTIFIED BACULOVIRUS;

EID: 0035879051     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570575     Document Type: Article

References (38)

1. Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases
2. Crystal structure of gingipain R: An Arg-specific bacterial cysteine proteinase with a caspase-like fold
3. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
4. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes
5. Pig kidney legumain: An asparaginyl endopeptidase with restricted specificity
6. Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis
7. Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins
8. Protein inhibitors of proteinases
9. Structural basis of the endopreteinase - Protein inhibitor interaction
10. Lysosomal cysteine proteases: More than scavengers
11. Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
12. Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease
13. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35
14. Interaction of the baculovirus anti-apoptotic protein p35 with caspases: Specificity, kinetics, and characterization of the caspase/p35 complex
15. Target protease specififity of the viral serpin CrmA: Analysis of five caspases
16. IAP family proteins - Suppressors of apoptosis
17. Granzyme B is inhibited by the cowpox virus serpin CrmA
18. Biochemical characteristics of caspases-3, -6, -7, and -8
19. Caspases: Preparation and characterization
20. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
21. Titration and mapping of the active site of cysteine proteinases from Porphyrornonas gingivalis (Gingipains) using peptidyl chloromethanes
22. Analysis of protein and peptide mixtures: Evaluation of three sodium dodecyl sulphate-polyacrylamide gel electrophoresis buffer systems
23. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes
24. X-linked IAP is a direct inhibitor of cell death proteases
25. Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases
26. Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex
27. Inhibition of cysteine and serine proteinases by the cowpox virus serpin CrmA
28. Inhibition of human caspases by peptide-based and macromolecular inhibitors
29. Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases
30. Crystal structure of the apoptotic suppressor CrmA in its cleaved form
31. Mutation of antitrypsin to antithrombin: A1-antitrypsin Pittsburgh (358 Met/Arg), a fatal breeding disorder
32. Mechanism of serpin action: Evidence that C1 inhibitor functions as a suicide substrate
33. Structure of a serpin-protease complex shows inhibition by deformation
34. The characterization of enzyme inhibition
35. Catalytic properties of the caspases
36. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
37. Crystal structure of baculovirus P35: Role of a novel reactive site loop in apoptotic caspase inhibition