Cytokine Gene Delivery into the Central Nervous System Using Intrathecally Injected Nonreplicative Viral Vectors

Methods in Molecular Biology

Volumn 215, Issue , 2003, Pages 279-289

  Furlan, Roberto ^a   Pluchino, Stefano ^a   Marconi, Peggy C ^b   Martino, Gianvito ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Bunsen Burner; Butterfly Needle; Cerebrospinal Fluid Sampling; Experimental Autoimmune Encephalomyelitis; Glass Needle

Indexed keywords

CYTOKINE;

ADENOVIRUS; ANIMAL; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; GENE TRANSFER; GENE VECTOR; GENETICS; HERPES SIMPLEX VIRUS 1; HUMAN; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; MOUSE;

ADENOVIRIDAE; ANIMALS; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CYTOKINES; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HUMANS; INJECTIONS, SPINAL; MICE;

MLCS; MLOWN;

EID: 0038348804     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1385/1-59259-345-3:279     Document Type: Chapter

References (18)

1. Saunders, N. R., Habgood, M. D., and Dziegielewska, K. M. (1999) Barrier mechanisms in the brain, I. Adult brain. Clin. Exp. Pharmacol. Physiol. 26, 11–19.
2. Martino, G. and Hartung, H. P. (1999) Immunopathogenesis of multiple sclerosis: the role of T cells. Curr. Opin. Neurol. 12, 309–321.
3. Hohlfeld, R. and Wiendl, H. (2001) The ups and downs of multiple sclerosis therapeutics. Ann. Neurol. 49, 281–284.
4. Martino, G., Poliani, P. L., Marconi, P., and Furlan, R. (2000) Cytokine gene therapy of autoimmune demyelination revisited using herpes simplex virus type-1-derived vectors. Gene Ther. 7, 1087–1093.
5. Martino, G., Furlan, R., Comi, G., and Adorini, L. (2001) The ependymal route to the CNS: an emerging gene therapy approach for MS. Trends Immunol. 22, 483–490.
6. Wu, N., Watkins, S. C., Schaffer, P. A., and DeLuca, N. A. (1996) Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J. Virol. 70, 6358–6369.
7. Marconi, P., Krisky, D., Oligino, T., Poliani, P. L., Ramakrishnan, R., Goins, W. F., et al. (1996) Replication-defective herpes simplex virus vectors for gene transfer in vivo. Proc. Natl. Acad. Sci. USA 93, 11,319–11,320.
8. Martino, G., Furlan, R., Galbiati, F., Poliani, P. L., Bergami, A., Grimaldi, L. M. E., et al. (1998) A gene therapy approach to treat demyelinating diseases using nonreplicative herpetic vectors engineered to produce cytokines. Multiple Sclerosis 4, 222–227.
9. Furlan, R., Poliani, P. L., Galbiati, F., Bergami, A., Grimaldi, L. M. E., Comi, G., et al. (1998) Central nervous system delivery of interleukin-4 by a non replicative herpes simplex type I viral vector ameliorates autoimmune demyelination. Hum. Gene Ther. 9, 2605–2617.
10. Furlan, R., Poliani P. L., Marconi, P. C., Bergami, A., Ruffini, F., Adorini, L., et al. (2001) Interleukin-4 gene delivery in the central nervous system at the time of disease onset inhibits progression of autoimmune demyelination. Gen. Ther. 8, 13–19.
11. Poliani, P. L., Brok, H., Furlan, R., Ruffini, F., Bergami, A., Desina, G., et al. (2001) Delivery of a non-replicative herpes simplex type-1 vector engineered with the IL-4 gene to the central nervous system protects rhesus monkeys from hyperacute autoimmune encephalomyelitis. Hum. Gene Ther. 12, 905–920.
12. Furlan, R., Brambilla, E., Ruffini, F., Poliani, P. L., Bergami, A., Marconi, P. C., et al. (2001) Intrathecal delivery of IFNγ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of CNS-infiltrating lymphocytes. J. Immunol. 167, 1821–1829.
13. Ruffini, F., Poliani, P. L., Brambilla, E., Marconi, P. C., Furlan, R., Bergami, A., et al. Short-term gene therapy using fibroblast growth factor-II induces remyelin-ation and protects mice from chronic experimental autoimmune encephalomyelitis. Gene Ther., in press.
14. Akli, S., Caillaud, C., Vigne, E., Stratford-Perricaudet, L. D., Poenaru, L., Perricaudet, M., et al. (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat. Genet. 3, 224–228.
15. Bajocchi, G., Feldman, S. H., Crystal, R. G., and Mastrangeli, A. (1993) Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nat. Genet. 3, 229–234.
16. Ohashi, T., Watabe, K., Uehara, K., Sly, W. S., Vogler, C., and Eto, Y. (1997) Adenovirus-mediated gene transfer and expression of human β-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice. Proc. Natl. Acad. Sci. USA 94, 1287–1292.
17. Driesse, M. J., Kros, J. M., Avezaat, C. J., Valerio, D., Vecht, C. J., Bout, A., et al. (1999) Distribution of recombinant adenovirus in the cerebrospinal fluid of nonhuman primates. Hum. Gene Ther. 10, 2347–2354.
18. Ueda, H., Amano, H., Shiomi, H., and Takagi, H. (1979) Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice. Eur. J. Pharmacol. 56, 265–268.