Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway

Molecular and Cellular Biology

Volumn 23, Issue 12, 2003, Pages 4126-4138

  Castro, Anna ^a   Vigneron, Suzanne ^a   Bernis, Cyril ^a   Labbé, Jean Claude ^a   Lorca, Thierry ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 20; CYCLIN B; HYBRID PROTEIN; KINESIN; PROTEIN XKID; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANAPHASE; ARTICLE; CELL CYCLE G1 PHASE; CHROMOSOME SEGREGATION; GERMINAL VESICLE; METAPHASE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SITE DIRECTED MUTAGENESIS; XENOPUS;

AMINO ACID MOTIFS; ANAPHASE; ANIMALS; BLOTTING, WESTERN; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GLUTATHIONE TRANSFERASE; KINESIN; METAPHASE; MITOSIS; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TIME FACTORS; XENOPUS; XENOPUS PROTEINS;

EID: 0038317575     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.12.4126-4138.2003     Document Type: Article

References (48)

1. Afshar, K., N. R. Barton, R. S. Hawley, and L. S. Goldstein. 1995. DNA binding and meiotic chromosomal localization of the Drosophila nod kinesin-like protein. Cell 81:129-138.
2. Antonio, C., I. Ferby, H. Wilhelm, M. Jones, E. Karsenti, A. R. Nebreda, and I. Vernos. 2000. Xkid, a chromokinesin required for chromosome alignment on the metaphase plate. Cell 102:425-435.
3. Burton, J. L., and M. J. Solomon. 2001. D box and KEN box motifs in budding yeast Hs11p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev. 15:2381-2395.
4. Burton, J. L., and M. J. Solomon. 2000. Hs11p, a Swelp inhibitor, is degraded via the anaphase-promoting complex. Mol. Cell. Biol. 20:4614-4625.
5. Carpenter, A. T. 1991. Distributive segregation: motors in the polar wind? Cell 64:885-890.
6. Castro, A., Y. Arlot-Bonnemains, S. Vigneron, J. C. Labbe, C. Prigent, and T. Lorca. 2002. APC/Fizzy-Related targets Aurora-A kinase for proteolysis. EMBO Rep. 3:457-462.
7. Castro, A., M. Peter, L. Magnaghi-Jaulin, S. Vigneron, S. Galas, T. Lorca, and J. C. Labbe. 2001. Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes. Mol. Biol. Cell 12:2660-2671.
8. Castro, A., S. Vigneron, C. Bernis, J. C. Labbe, C. Prigent, and T. Lorca. 2002. D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A. EMBO Rep. 3:1209-1214.
9. Cohen-Fix, O., J. M. Peters, M. W. Kirschner, and D. Koshland. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10: 3081-3093.
10. 1. Mol. Cell 2:163-171.
11. Fesquet, D., N. Morin, M. Doree, and A. Devault. 1997. Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling Xenopus egg extracts? Oncogene 15:1303-1307.
12. Fuller, M. T. 1995. Riding the polar winds: chromosomes motor down east, Cell 81:5-8.
13. Funabiki, H., and A. W. Murray. 2000. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell 102:411-424.
14. Germani, A., H. Bruzzoni-Giovanelli, A. Fellous, S. Gisselbrecht, N. Varin-Blank, and F. Calvo. 2000. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Oncogene 19: 5997-6006.
15. Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349:132-138.
16. Hagting, A., N. Den Elzen, H. C. Vodermaier, I. C. Waizenegger, J. M. Peters, and J. Pines. 2002. Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157:1125-1137.
17. Hames, R. S., S. L. Wattam, H. Yamano, R. Bacchieri, and A. M. Fry. 2001. APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-Box. EMBO J. 20:7117-7127.
18. Hilioti, Z., Y. S. Chung, Y. Mochizuki, C. F. Hardy, and O. Cohen-Fix. 2001. The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. Curt. Biol. 11:1347-1352.
19. King, R. W., M. Glotzer, and M. W. Kirschner. 1996. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Biol. Cell 7:1343-1357.
20. Kramer, E. R., C. Gieffers, G. Holzl, M. Hengstschlager, and J. M. Peters. 1998. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. Curr. Biol. 8:1207-1210.
21. Kramer, E. R., N. Scheuringer, A. V. Podtelejnikov, M. Mann, and J. M. Peters. 2000. Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol. Biol. Cell 11:1555-1569.
22. Littlepage, L. E., and J. V. Ruderman. 2002. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev. 16:2274-2285.
23. Lorca, T., A. Castro, A. M. Martinez, S. Vigneron, N. Morin, S. Sigrist, C. Lehner, M. Doree, and J. C. Labbe. 1998. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts. EMBO J. 17:3565-3575.
24. Maney, T., A. W. Hunter, M. Wagenbach, and L. Wordeman. 1998. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J. Cell Biol. 142:787-801.
25. Perez, L. H., C. Antonio, S. Flament, I. Vernos, and A. R. Nebreda. 2002. Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes. Nat. Cell Biol. 4:737-742.
26. Pfleger, C. M., and M. W. Kirschner. 2000. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14:655-665.
27. Pfleger, C. M., E. Lee, and M. W. Kirschner. 2001. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev. 15:2396-2407.
28. Reimann, J. D., E. Freed, J. Y. Hsu, E. R. Kramer, J. M. Peters, and P. K. Jackson. 2001. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 105:645-655.
29. Reimann, J. D., B. E. Gardner, F. Margottin-Goguet, and P. K. Jackson. 2001. Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Genes Dev. 15:3278-3285.
30. Rieder, C. L., E. A. Davison, L. C. Jensen, L. Cassimeris, and E. D. Salmon. 1986. Oscillatory movements of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle. J. Cell Biol. 103:581-591.
31. Savoian, M. S., M. L. Goldberg, and C. L. Rieder. 2000. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants. Nat. Cell Biol. 2:948-952.
32. Schwab, M., A. S. Lutum, and W. Seufert. 1997. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90:683-693.
33. Schwab, M., M. Neutzner, D. Mocker, and W. Seufert. 2001. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J. 20:5165-5175.
34. Sharp, D. J., G. C. Rogers, and J. M. Scholey. 2000. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos. Nat. Cell Biol. 2:922-930.
35. Sigrist, S. J., and C. F. Lehner. 1997. Drosophila fizzy-related downregulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90:671-681.
36. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hershko, F. C. Luca, J. V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6:185-197.
37. Tokai, N., A. Fujimoto-Nishiyama, Y. Toyoshima, S. Yonemura, S. Tsukita, J. Inoue, and T. Yamamota. 1996. Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. EMBO J. 15:457-467.
38. Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278:460-463.
39. Walczak, C. E., T. J. Mitchison, and A. Desai. 1996. XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 84:37-47.
40. Weinstein, J. 1997. Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc: a mammalian homolog of CDC20/Fizzy/slp1. J. Biol. Chem. 272:28501-28511.
41. Wood, K. W., R. Sakowicz, L. S. Goldstein, and D. W. Cleveland. 1997. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell 91:357-366.
42. Yeong, F. M., H. H. Lim, C. G. Padmashree, and U. Surana. 2000. Exit from mitosis in budding yeast: biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20. Mol. Cell 5:501-511.
43. You, Z., Harvey, K., Kong, L., and J. Newport. 2002. Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication Genes Dev. 16:1182-1194.
44. Zacharfae, W., and K. Nasmyth. 1999. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13:2039-2058.
45. Zhang, P., B. A. Knowles, L. S. Goldstein, and R. S. Hawley. 1990. A kinesin-like protein required for distributive chromosome segregation in Drosophila. Cell 62:1053-1062.
46. Zou, H., T. J. McGarry, T. Bernal, and M. W. Kirschner. 1999. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285:418-422.
47. Zur, A., and M. Brandeis. 2001. Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. EMBO J. 20:792-801.
48. Zur, A., and M. Brandeis. 2002. Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes. EMBO J. 21:4500-4510.