Identification of the promoter, genomic structure, and mouse ortholog of LGI1

Mammalian Genome

Volumn 11, Issue 8, 2000, Pages 622-627

  Somerville, Robert P T ^b   Chernova, Olga ^b   Liu, Siqing ^b   Shoshan, Yigal ^a,b   Cowell, John K ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; EXON; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PROMOTER REGION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTHERN BLOTTING;

RODENTIA;

EID: 0038285465     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s0033500101280     Document Type: Article

References (43)

1. Bostrom J, Cobbers JM, Wolter M, Tabatabai G, Weber RG et al. (1998) Mutation of the PTEN (MMAC1 ) tumor suppressor gene in a subset of glioblustomas but not in meningiomas with loss of chromosome arm 10q. Cancer Res 58, 29-33
2. Chang Z, Price BD, Bockheim S, Boedigheimer MJ, Smith R et al. (1993) Molecular and genetic characterization of the Drosophila tartan gene. Dev Biol 160, 315-332.
3. Chernova O, Cowell JK. (1998) Molecular definition of chromosome translocations involving 10q24 and 19q13 in human malignant glioma cells. Cancer Genet Cytogenet 105, 60-68
4. Chernova OB, Somerville RP, Cowell JK. (1998) A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene 17, 2873-2881
5. Chiariello E, Roz L, Albarosa R, Magnani I, Finocchiaro G (1998) PTEN/ MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. Oncogene 16, 541-545
6. Chomczynski P, Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanale-phenol-chloroform extraction. Anal Biochem 162, 156-159
7. Davies MP, Gibbs FE, Halliwell N, Joyce KA, Roebuck MM et al. (1999) Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas. Br J Cancer 79, 1542-1548
8. Duerr EM, Rollbrocker B, Hayashi Y, Peters N, Meyer-Puttlitz B et al. (1998) PTEN mutations in gliomas and glioneuronal tumors. Oncogene 16, 2259-2264
9. Fisher LW, Heegaard AM, Vetter U, Vogel W, Just W et al. (1991) Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. J Biol Chem 266, 14371-14377
10. Fujimoto M, Fults DW, Thomas GA, Nakamura Y, Heilbrun MP et al. (1989) Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme. Genomics 4, 210-214
11. Fukuyama K, Matsuzawa K, Hubbard SL, Dirks PB, Murakami M et al. (1996) Analysis of glial fibrillary acidic protein gene methylation in human malignant gliomas. Anticancer Res 16, 1251-1257
12. Fults D, Pedone CA, Thompson GE, Uchiyama CM, Gumpper KL et al. (1998) Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme. Int J Oncol 12, 905-910
13. Furnari FB, Lin H, Huang HS, Cavenee WK (1997) Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci USA 94, 12479-12484
14. Graff JR, Herman JG, Myohanen S, Baylin SB, Vertino PM (1997) Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem 272, 22322-22329
15. Greger V, Debus N, Lohmann D, Hopping W, Passarge E et al. (1994) Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. Hum Genet 94, 491-496
16. Grover J, Roughley PJ. (1998) Characterization of the human proline/ arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element. Biochem J 336 (Pt 1), 77-82
17. Li DM, Sun H (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 57, 2124-2129
18. Li J, Yen C, Liaw D, Podsypanina K, Bose S et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [see comments]. Science 275, 1943-1947
19. Lin H, Bondy ML, Langford LA, Hess KR, Delclos CL et al. (1998) Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance. Clin Cancer Res 4, 2447-2454
20. Liu W, James CD, Frederick L, Alderete BE, Jenkins RB (1997) PTEN/ MMAC1 mutations and EGFR amplification in glioblastomas. Cancer RES 57, 5254-5257
21. Lo KW, Cheung ST, Leung SF, van Hasselt A, Tsang YS et al (1996) Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 56, 2721-2725
22. Maier D, Comparone D, Taylor E, Zhang Z, Gratzl O et al. (1997) New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26. Oncogene 15, 997-1000
23. Maier D, Zhang Z, Taylor E, Hamou MF, Grulzl O et al. (1998) Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/ MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. Oncogene 16, 3331-3335
24. Mao X, Jones TA, Tomlinson I, Rowan AJ, Fedorova LI et al. (1999) Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line. Br J Cancer 79, 724-731
25. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y et al. (1997) DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. Nat Genet 17, 32-39
26. Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M et al. (1998) Identification of a human homolog of the Drosophila neutralized gene within the 10q25.1 malignant astrocytoma deletion region. Oncogene 16, 1009-1019
27. Ng HK, Lam PY (1998) The molecular genetics of central nervous system tumors. Pathology 30, 196-202
28. Padgett RA, Grabowski PJ, Konarska MM, Seiler S, Sharp PA (1986) Splicing of messenger RNA precursors. Annu Rev Biochem 55, 1119-1150
29. Peraud A, Watanabe K, Schwechheimer K, Yonekawa Y, Kleihues P et al. (1999) Genetic profile of the giant cell glioblastoma. Lab Invest 79, 123-129
30. Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH et al. (1997) PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res 57, 4187-4190
31. Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas S (1988) slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell 55, 1047-1059
32. Rothberg JM, Jacobs JR, Goodman CS, Artavanis-Tsakonas S. (1990) slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev 4, 2169-2187
33. Sambrook J, Fritsch EF, Maniatis T, (1982) Molecular Cloning: A Laboratory Manual, (Nolan Editor Cold Spring Harbor NY)
34. Somerville RP, Shoshan Y, Eng C, Barnett G, Miller D et al. (1998) Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene 17, 1755-1757
35. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H et al. (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15, 356-362
36. Taguchi A, Wanaka A, Mori T, Matsumoto K, Imai Y et al. (1996) Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res 35, 31-40
37. Tohma Y, Gratas C, Biernat W, Peraud A, Fukuda M et al. (1998) PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. J Neuropathol Exp Neurol 57, 684-689
38. Tong CY, Ng HK, Pang JC, Hui AB, Ko HC et al. (1999) Molecular genetic analysis of non-astrocytic gliomas [see comments]. Histopathology 34, 331-341
39. von Deimling A, Louis DN, von Ammon K, Petersen I, Hoell T et al. (1992) Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J Neurosurg 77, 295-301
40. Wang SI, Puc J, Li J, Bruce JN, Cairns P et al. (1997) Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 57, 4183-4186
41. Watanabe K, Peraud A, Gratas C, Wakai S, Kleihues P et al. (1998) p53 and PTEN gene mutations in gemistocytic astrocytomas. Acta Neuropathol (Berl) 95, 559-564
42. Wegrowski Y, Pillarisetti J, Danielson KG, Suzuki S, Iozzo RV (1995) The murine biglycan: complete cDNA cloning, genomic organization, promoter function, and expression. Genomics 30, 8-17
43. Ying S, Shiraishi A, Kao CW, Converse RL, Funderburgh JL et al. (1997) Characterization and expression of the mouse lumican gene. J Biol Chem 272, 30306-30313