Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2003, Pages 2169-2176

  Gentili, Francesco ^a   Bousquet, Pascal ^b   Brasili, Livio ^c   Dontenwill, Monique ^b   Feldman, Josiane ^b   Ghelfi, Francesca ^a   Giannella, Mario ^a   Piergentili, Alessandro ^a   Quaglia, Wilma ^a   Pigini, Maria ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 METHYL 2 PHENYLETHYL) 4,5 DIHYDRO 1H IMIDAZOLE OXALATE; 2 (2 PHENYLPROPYL) 4,5 DIHYDRO 1H IMIDAZOLE MALEATE; 2 PHENOXYMETHYLIMIDAZOLINE; BRIDGED COMPOUND; ETHYLENE; IMIDAZOLINE; IMIDAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CHEMICAL PARAMETERS; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; MALE; METHYLATION; NONHUMAN; RAT; STEREOSPECIFICITY;

ANIMALS; BINDING SITES; BLOOD PRESSURE; HEART RATE; IMIDAZOLES; KIDNEY; MALE; PC12 CELLS; RABBITS; RADIOLIGAND ASSAY; RATS; RECEPTORS, DRUG; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038248835     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021113r     Document Type: Article

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