Characterization of I2 imidazoline and σ binding sites in the rat and human stomach

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 1, 1998, Pages 170-177

  Molderings, Gerhard J ^a   Donecker, Kurt ^a   Burian, Maria ^a   Simon, W Alexander ^b   Schröder, Detlev W ^c   Göthert, Manfred ^a  

^a UNIVERSITY OF BONN   (Germany)

^b ALTANA PHARMA AG   (Germany)

^c EVANGELISCHES KRANKENHAUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 2 (2 IMIDAZOLIN 2 YLAMINO)ISOINDOLINE; CIRAZOLINE; CLONIDINE; IDAZOXAN; IMIDAZOLINE; RADIOLIGAND; 1,3 DITOLYLGUANIDINE; 1,3-DITOLYLGUANIDINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMINOPHENAZONE; ANTICONVULSIVE AGENT; GUANIDINE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; BINDING SITE; LIGAND BINDING; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; STOMACH MUSCLE; ANIMAL; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MUSCLE CONTRACTION; RABBIT; RAT; STOMACH; STOMACH FUNDUS; STOMACH MUCOSA; WISTAR KYOTO RAT;

ADRENERGIC ALPHA-ANTAGONISTS; AMINOPYRINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; BINDING SITES; FEMALE; GASTRIC FUNDUS; GASTRIC MUCOSA; GUANIDINES; HUMANS; IDAZOXAN; MALE; MUSCLE CONTRACTION; RABBITS; RATS; RATS, INBRED WKY; STOMACH;

EID: 0031594201     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Atlas D (1991) Clonidine-displacing substance (CDS) and its putative imidazoline receptor. Biochem Pharmacol 41:1541-1549.
2. Berglindh T (1977) Potentiation by carbachol and aminophylline of histamine-and db-cAMP-induced parietal cell activity in isolated gastric glands. Acta Physiol Scand 99:75-84.
3. Bhandare PM, Rataboli PV and D'Souza RSD (1991) Dual action of clonidine on ethanol-induced gastric lesions: Is the imidazoline-preferring receptor involved? Eur J Pharmacol 199:243-245.
4. 2-adrenoceptor subtypes involved in the modulation of gastric acid secretion. Eur J Pharmacol 278:179-182.
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
6. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR and Trendelenburg U (1994) International union of pharmacology nomenclature of adrenoceptors. Pharmacol Rev 46:121-136.
7. Carlisle MA, Smyth DD and Glavin GB (1995) Efaroxan acts peripherally to block the antisecretory and gastroprotective effects of moxonidine in rat. J Pharmacol Exp Ther 274:598-601.
8. 50) of an enzyme reaction. Biochem Pharmacol 22:3099-3108.
9. Chew CS (1994) Parietal cell culture: New models and directions. Annu Rev PAysiol 56:445-461.
10. DeBlasi A, O'Reilly K and Motulsky HJ (1989) Calculating receptor number from binding experiments using same compound as radioligand and competitor. Trends Pharmcaol Sci 10:227-229.
11. 3H]1,3-di(2-tolyl)guanidine (DTG)-defined σ recognition sites in guinea pig brain. Life Sci 50:PL65-PL70.
12. De Lean A, Hancock AA and Lefkowitz RJ (1982) Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol Pharmacol 21:5-16.
13. Del Tacca M, Soldani G, Bernardini C, Martinotti E and Impicciatore M (1982) Pharmacological studies on the mechanisms underlying the inhibitory and excitatory effects of clonidine on gastric acid secretion. Eur J Pharmacol 81:255-261.
14. Felsen D, Ernsberger P, Meeley MP and Reis DJ (1987) Clonidine displacing substance is biologically active on smooth muscle. Eur J Pharmacol 142:453-455.
15. Glavin GB and Smyth DD (1995) Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br J Pharmacol 114:751-754.
16. Glavin GB, Carlisle MA and Smyth DD (1995) Agmatine, an endogenous imidazoline receptors agonist, increases gastric secretion and worsens experimental gastric mucosal injury in rats. J Pharmacol Exp Ther 274:741-744.
17. 3H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa. J Pharmacol Exp Ther 269:905-910.
18. 2 receptor antagonists on acid secretion stimulated by imidazoline derivatives in isolated parietal cells. Eur J Pharmacol 144:67-76.
19. Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R and Reis DJ (1994) Agmatine: An endogenous clonidine-displacing substance in the brain. Science (Wash DC) 263:966-969.
20. 3H]SKF-10,047 to σ sites. Eur J Pharmacol 180:361-364.
21. Medgett IC and McCulloch MW (1979) Effects of clonidine, guanfacine and three imidazolidine derivatives related to clonidine on blood pressure, heart rate and gastric acid secretion in the anaesthetized rat. Arch Int Pharmacodyn 240:158-168.
22. Meeley MP, Ernsberger PR, Granata AR and Reis DJ (1986) An endogenous clonidine-displacing substance from bovine brain: Receptor binding and hypotensive actions in the ventrolateral medulla. Life Sci 38:1119-1126.
23. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains. J Pharmacol Exp Ther 264:1187-1197.
24. Molderings GJ (1997) Imidazoline receptors: Basic knowledge, recent advances and future prospects for therapy and diagnosis. Drugs Fut 22:757-772.
25. 3H]clonidine binding sites in rat stomach: High affinity of imidazolines, guanidines and sigma ligands. Naunyn-Schmiedeberg's Arch Pharmacol 351:561-564.
26. 2-imidazoline sites. Naunyn-Schmiedeberg's Arch Pharmacol 350:252-257.
27. 1-imidazoline sites in bovine adrenal medullary membranes. Naunyn-Schmiedeberg's Arch pharmacol 348:70-76.
28. 2 binding sites. Naunyn-Schmiedeberg's Arch Pharmacol 354:245-252.
29. Piletz JE, Chikkala DN and Ernsberger P (1995) Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J Pharmacol Exp Ther 272:581-587.
30. Regunathan S, Meeley MP and Reis DJ (1993) Expression of non-adrenergic imidazoline sites in chromaffin cells and mitochondrial membranes of bovine adrenal medulla. Biochem Pharmacol 45:1667-1675.
31. Regunathan S and Reis DJ (1996) Imidazoline receptors and their endogenous ligands. Anna Rev Pharmacol Toxicol 36:511-544.
32. +)-ATPase inhibitor. Biochem Pharmacol 39:1799-1806.
33. 4 receptors: Curiouser and curiouser. Trends Pharmacol Sci 15:317-319.
34. Tesson F, Limon I and Parini A (1992) Tissue-specific localization of mitochondrial imidazoline-guanidinium receptive sites. Eur J Pharmacol 219:335-338.
35. Weber E, Sonders M, Quarum M, McLean S, Pou S and Keana JFW (1986) 1,3-Di(2-(5-3H)tolyl)guanidine: A selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs. Proc Natl Acad Sci USA 83:8784-8788.
36. 3H]-Idazoxan binding sites (I-receptors) occurs to interacting or interconvertible affinity forms of receptor. Pharmacol Toxicol 70:208-219.