Imaging pulmonary gene expression with positron emission tomography

American Journal of Respiratory and Critical Care Medicine

Volumn 167, Issue 9, 2003, Pages 1257-1263

  Richard, Jean Cristophe ^b   Zhou, Zhaohui ^b   Ponde, Datta E ^b   Dence, Carmen S ^b   Factor, Philip ^b   Reynolds, Paul N ^b   Luker, Gary D ^b   Sharma, Vijay ^b   Ferkol, Tom ^b   Piwnica Worms, David ^b   Schuster, Daniel P ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b NONE

Author keywords

Green fluorescent protein; Positron emission tomography; Rats; Reporter gene

Indexed keywords

9 (4 FLUORO 3 HYDROXYMETHYLBUTYL)GUANINE F 18; GREEN FLUORESCENT PROTEIN; RADIOACTIVE MATERIAL; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FUSION GENE; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOACTIVITY; RAT; REPORTER GENE; TRANSGENE; VIRUS INFECTION; VIRUS MUTANT; VIRUS PARTICLE; VIRUS REPLICATION;

ANALYSIS OF VARIANCE; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORODEOXYGLUCOSE F18; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GUANINE; HERPESVIRUS 1, HUMAN; LEAST-SQUARES ANALYSIS; LUNG; LUNG DISEASES; MODELS, ANIMAL; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; THYMIDINE KINASE; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED; TRANSGENES; TREATMENT OUTCOME;

EID: 0038216662     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200210-1217OC     Document Type: Article

References (34)

1. Factor P. Gene therapy for acute diseases. Mol Ther 2001;4:515-524.
2. Weiss YG, Maloyan A, Tazelaar J, Raj N, Deutschman CS. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest 2002;110:801-806.
3. Yang M, Baranov E, Moossa AR, Penman S, Hoffman RM. Visualizing gene expression by whole-body fluorescence imaging. Proc Natl Acad Sci USA 2000;97:12278-12282.
4. Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Optical imaging of cardiac reporter gene expression in living rats. Circulation 2002;105:1631-1634.
5. Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP. In vivo magnetic resonance imaging of transgene expression. Nat Med 2000;6:351-355.
6. Cherry SR, Gambhir SS. Use of positron emission tomography in animal research. ILAR J 2001;42:219-232.
7. Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Positron emission tomography imaging of cardiac reporter gene expression in living rats. Circulation 2002;106:180-183.
8. Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci USA 2002;99:6961-6966.
9. Gambhir SS, Bauer E, Black ME, Liang Q, Kokoris MS, Barrio JR, Iyer M, Namavari M, Phelps ME, Herschman HR. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci USA 2000;97:2785-2790.
10. Factor P, Mendez M, Mutlu GM, Dumasius V. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Respir Crit Care Med 2002;165:521-526.
11. Factor P, Dumasius V, Saldias F, Brown LA, Sznajder JI. Adenovirus-mediated transfer of an Na+/K+-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum Gene Ther 2000;11:2231-2242.
12. 18F]FHBG): a new potential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol 1998;25:175-180.
13. Cherry SR, Shao Y, Silverman RW, Chatziioannou A, Meadors K, Siegel S, Farquhar T, Young J, Jones WF, Newport D, et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci 1997;44:1161-1166.
14. Tai YC, Chatziioannou A, Siegel S, Young J, Newport D, Goble RN, Nutt RE, Cherry SR. Performance evaluation of the microPET P4: a PET system dedicated to animal imaging. Phys Med Biol 2001;46:1845-1862.
15. Hruby DE, Ball LA. Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase. Virology 1981;113:594-601.
16. Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamurthy N, Wu L, Green LA, Bauer E, MacLaren DC, et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci USA 1999;96:2333-2338.
17. Gambhir SS, Barrio JR, Herschman HR, Phelps ME. Assays for noninvasive imaging of reporter gene expression. Nucl Med Biol 1999;26:481-490.
18. MacLaren DC, Toyokuni T, Cherry SR, Barrio JR, Phelps ME, Herschman HR, Gambhir SS. PET imaging of transgene expression. Biol Psychiatry 2000;48:337-348.
19. Gambhir SS, Herschman HR, Cherry SR, Barrio JR, Satyamurthy N, Toyokuni T, Phelps ME, Larson SM, Balatoni J, Finn R, et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2000;2:118-138.
20. MacLaren DC, Gambhir SS, Satyamurthy N, Barrio JR, Sharfstein S, Toyokuni T, Wu L, Berk AJ, Cherry SR, Phelps ME, et al. Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther 1999;6:785-791.
21. Tjuvajev JG, Avril N, Oku T, Sasajima T, Miyagawa T, Joshi R, Safer M, Beattie B, DiResta G, Daghighian F, et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 1998;58:4333-4341.
22. Gambhir SS, Barrio JR, Wu L, Iyer M, Namavari M, Satyamurthy N, Bauer E, Parrish C, MacLaren DC, Borghei AR, et al. Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J Nucl Med 1998;39:2003-2011.
23. Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther 2002;6:73-82.
24. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Finn R, Bornmann W, Thaler H, Conti PS, et al. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med 2002;43:1072-1083.
25. Schuster DP. Positron emission tomography: theory and its application to the study of lung disease. Am Rev Respir Dis 1989;139:818-840.
26. Lehnert S, Schreiner LJ, el-Khatib E. Factors influencing lung density in experimental models: results of studies using CT densitometry. Physiol Meas 1993;14:183-193.
27. Schuster DP, Marklin GF, Mintun MA, Ter-Pogossian MM. PET measurement of regional lung density; 1. J Comput Assist Tomogr 1986;10:723-729.
28. Phelps ME. PET: a biological imaging technique. Neurochem Res 1991;16:929-940.
29. Sun X, Annala AJ, Yaghoubi SS, Barrio JR, Nguyen KN, Toyokuni T, Satyamurthy N, Namavari M, Phelps ME, Herschman HR, et al. Quantitative imaging of gene induction in living animals. Gene Ther 2001;8:1572-1579.
30. Cass CE, Young JD, Baldwin SA, Cabrita MA, Graham KA, Griffiths M, Jennings LL, Mackey JR, Ng AM, Ritzel MW, et al. Nucleoside transporters of mammalian cells. Pharm Biotechnol 1999;12:313-352.
31. Zinn KR, Chaudhuri TR, Krasnykh VN, Buchsbaum DJ, Belousova N, Grizzle WE, Curiel DT, Rogers BE. Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice. Radiology 2002;223:417-425.
32. 124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur J Nucl Med 2001;28:721-729.
33. Gelband CH, Katovich MJ, Raizada MK. Current perspectives on the use of gene therapy for hypertension. Circ Res 2000;87:1118-1122.
34. (18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 2001;42:1225-1234.