A new, general and regioselective method for the synthesis of 2,6-disubstituted 4-aminopteridines

Tetrahedron Letters

Volumn 38, Issue 39, 1997, Pages 6835-6836

  Taghavi Moghadam, Shahriyar ^a   Pfleiderer, Wolfgang ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPTERIN DERIVATIVE; PTERIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030861885     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01619-5     Document Type: Article

References (6)

1. For general references on pteridine chemistry: Pfleiderer, W. in "Comprehensive Heterocyclic Chemistry", Katritzky A.R; Rees C. W., eds, Vol 3, Part 2B, Pergamon Press, Oxford, 1984, p 263-327.
2. Kang, Y.; Soyka, R.; Pfleiderer, W. J. Heterocyclic Chem. 1987, 24, 597-601.
3. Montgomery, J.A.; Piper, J.R.; Elliott, R.D.; Roberts, E.C.; Temple, C.; Shealy, Y.F. J. Heterocyclic Chem. 1987, 24, 279-282.
4. 6), δ (s, 1H, C(7)-H,): 3a: 8.60, 3b: 8.84, 3c: 8.84, 3d: 8.63, 3e: 9.33, 3f: 9.31, 3g: 8.97, 3h: 9.21, 3i: 9.69, 3j: 9.68, 3k: 8.85, 31: 9.09, 3m: 9.09, 3n: 9.61, 3o: 9.57, 3p: 8.97, 3q: 9.21, 3r: 9.21, 3s: 9.74, 3t: 9.70.
5. The results of these studies have been applied for a patent by LONZA AG, Visp-Basel/Switzerland Pfleiderer, W.; Taghavi-Moghadam, Schweiz. Patentgesuch-No. 03503/95.
6. 4.