On the safety of a new generation of DSM Aspergillus niger enzyme production strains

Regulatory Toxicology and Pharmacology

Volumn 38, Issue 1, 2003, Pages 27-35

  Van Dijck, Piet W M ^a   Selten, Gerard C M ^a   Hempenius, Rixta A ^a  

^a DSM FOOD SPECIALTIES   (Netherlands)

Author keywords

Aspergillus niger; Enzyme safety; Genetic engineering; Micro organism; Secondary metabolites

Indexed keywords

GLUCAN 1,4 ALPHA GLUCOSIDASE;

ARTICLE; ASPERGILLUS NIGER; ENZYME SYNTHESIS; FUNGAL STRAIN; GENE EXPRESSION; HAZARD ASSESSMENT; HOST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SAFETY;

ANIMALIA; ASPERGILLUS NIGER;

EID: 0038159924     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-2300(03)00049-7     Document Type: Article

References (30)

1. Abarca M.L., Accensi F., Bragulat M.R., Cabanes F.J. Current importance of ochratoxin A-producing Aspergillus spp. J. Food Prot. 64:2001;903-906.
2. Aunstrup K., Andresen O., Falch E.A., Nielsen T.K. Production of microbial enzymes. Peppler H.J., Perlman D. Microbial Technology. second ed. Microbial processes. vol. I:1979;281-309 Academic Press, New York.
3. Bennett, J.W., 1988. Proposed acceptable daily intake (ADI) levels for enzymes from organisms not commonly considered to be constituents of food. Report for JECFA dated September 14, 1988.
4. Committee on Food Chemicals Codex, 1996. Food Chemicals Codex. National Academy Press. Washington, DC.
5. Douglas J.S., Barraj L.M., Tennant D.R., Long W.R., Chaisson C.F. Evaluation of the budget method for screening food additive intakes. Food Add. Contamin. 14:1997;791-802.
6. Frisvad J.C., Filtenborg O. Terverticillate penicillia: chemotaxonomy and mycotoxin production. Mycologia. 81:1989;837-861.
7. Frisvad J.C., Thrane U. Standardized high-performance liquid chromatography of 182 mycotoxins and other fungal metabolites based on alkylphenone retention indices and UV-Vis spectra (diode array detection). J. Chromatogr. 404:1987;195-214.
8. Frisvad, J.C., Thrane, U., 1993. Liquid column chromatography of mycotoxins. In: Betina, V. (Ed.), Chromatography of Mycotoxins. Techniques and Applications. Journal of Chromatography Library, vol. 54. Elsevier, Amsterdam, pp. 253-372.
9. Gill R.T., Valdes J.J., Bently W.E. A comparative study of global stress gene regulation in response to overexpression of recombinant proteins in Escherichia coli. Metab. Eng. 2:2000;178-189.
10. Groot, G., Pel, H., van Ooyen, A.J.J., 2002. Exploring and exploiting the Aspergillus niger genome. SIM Annual Meeting abstracts S68, p. 77.
11. International Food Biotechnology Council (IFBC), 1990. Safety evaluation of foods and food ingredients derived from microorganisms in biotechnologies and food: assuring the safety of foods produced by genetic modification. Reg. Toxicol. Pharmacol. 12, S1-S196.
12. Joint FAO/WHO Expert Committee on Food Additives, 1975. Toxicological evaluation of some food colours, enzymes, flavour enhancers, thickening agents, and certain other food additives. WHO Food Additives Series 6, 124-128.
13. Joint FAO/WHO Expert Committee on Food Additives, 1988. Enzymes derived from Aspergillus niger. In Toxicological evaluation of certain additives. WHO Food Additives Series 22, 11-23.
14. Joint FAO/WHO Expert Committee on Food Additives, 1991. 3.1.2 Enzyme preparations. Enzyme preparations from Aspergillus niger + Annex 2. Toxicological evaluation of certain additives. Report 35th meeting JECFA. WHO Technical Report Series 789, pp. 15+44-46.
15. Joint FAO/WHO Expert Committee on Food Additives, 1992. General specifications for enzyme preparations used in food processing. Food and Nutrition Paper No 52/2, Annex 1.
16. Kessler D.A., Taylor M.R., Maryanski J.H., Flamm E.L., Kahl L.S. The safety of foods developed by biotechnology. Science. 256:1992;1747-1749. 1832.
17. Löwik M.R.H., Hulshof K.F.A.M., van der Heiijden J.M., Brussaard J.H., Burema J., Kistemaker C., de Vries P.J.F. Changes in the diet in the Netherlands: 1987-1988 to 1992 (Dutch Nutrition Surveillance System). Int. J. Food Sci. Nutr. 49(Suppl. 1):1998;S1-S64.
18. Moss M.O., 1988. The occurrence and significance of mycotoxins. Report for JECFA dated September 1988.
19. Noordervliet P.F., Toet D.A. Safety in enzyme technology. Rehm H.J., Reed G. Biotechnology. vol. 7A:1987;711-741 VCH Verlagsgesellschaft, Weinheim, Germany.
20. Pariza M.W., Foster E.M. Determining the safety of enzymes used in food processing. J. Food Prot. 46:1983;453-463.
21. Pariza M.W., Johnson E.A. Evaluating the safety of microbial enzyme preparations used in food processing: update for a new century. Reg. Toxicol. Pharmacol. 33:2001;1-14.
22. Patil C., Walter P. Intracellular signalling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell. Biol. 13:2001;349-355.
23. Reed G. Health and legal aspects of the use of enzymes. Reed G. Enzymes in Food Processing. second ed. 1975;549-554 Academic Press, New York.
24. Röhr M., Cubicek C.P., Kominek J. Citric acid. Rehm H.J., Reed G. Biotechnology. vol. 3:1983;419-454 VCH Verlagsgesellschaft, Weinheim, Germany.
25. Schuster E., Dunn-Coleman N., Frisvad J.C., van Dijck P.W.M. On the safety of Aspergillus niger - a review. Appl. Microbiol. Biotechnol. 59:2002;426-435.
26. Scientific Committee for Food, 1992. Guidelines for the presentation of data on food enzymes. Report of the Scientific Committee for Food, 27th Report Series (EUR 14181 EN). Office for Official Publications of the EEC, pp. 13-22.
27. Selten, G.C.M, van Gorcom, R.F.M., Swinkels, B.W., 1995. Selection marker gene free recombinant strains: a method for obtaining them and the use of these strains. European Patent Application EPO0635574 A1.
28. Selten, G.C.M., Swinkels, B.W., Bovenberg, R.A.L., 1998. Gene conversion as a tool for the construction of recombinant industrial filamentous fungi. International Patent Application WO 98/46772.
29. Van Dijck, P.W.M., Spierenburg, H., Frisvad, J.C., Samson, R.A., 2002. The influence of strain improvement and genetic modification on the pattern of secondary metabolites in industrial strains of Penicillium chrysogenum and Aspergillus niger. Abstract 10th IUMS, Paris, June 27-July 1, M-60, p. 23.
30. Varga J., Kevei F., Hamari Z., Tóth B., Téren J., Croft J.H., Kozakiewiz Z. Genotypic and phenotypic variability among black aspergilli. Samson R.A., Pitt J.I. Integration of Modern Taxonomic methods for Penicillium and Aspergillus Classification. 2000;397-411 Harwood Academic Publishers, Amsterdam.