Vito Turk - 30 years of research on cysteine proteases and their inhibitors

Biological Chemistry

Volumn 384, Issue 6, 2003, Pages 833-836

  Turk, Boris ^a   Fritz, Hans ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; CATHEPSIN B; CATHEPSIN D; CATHEPSIN H; CATHEPSIN L; CATHEPSIN S; CYSTATIN; CYSTEINE PROTEINASE; KININOGEN; PAPAIN; PLASMA PROTEIN; PROTEINASE INHIBITOR; RECOMBINANT DNA; STEFIN B; SULFONE DERIVATIVE;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; APOPTOSIS; CANCER; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG TARGETING; EDITORIAL; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; INFLAMMATION; MEDICAL RESEARCH; PRIORITY JOURNAL; PROFESSIONAL PRACTICE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; RECOMBINANT DNA TECHNOLOGY; STRUCTURE ACTIVITY RELATION;

BIOCHEMISTRY; CROATIA; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; PORTRAITS;

EID: 0038148113     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.093     Document Type: Editorial

References (29)

1. Bevec, T., Stoka, V., Pungerčič, G., Dolenc, I. and Turk, V. (1996). Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L. J. Exp. Med. 183, 1331-1338.
2. Bode, W., Engh, R., Musil, D.J., Thiele, U., Huber, R., Karshikov, A., Brzin, J., Kos, J. and Turk, V. (1988). The 2.0 Å X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. EMBO J. 7, 2593-2599.
3. Dahl, S.W., Halkier, T., Lauritzen, C., Dolenc, I., Pedersen, J., Turk, V., and Turk, B. (2001). Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing. Biochemistry 40, 1671-1678.
4. Gunčar, G., Pungerčič, G., Klemenčič, I., Turk, V. and Turk, D. (1999). Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. EMBO J. 18, 793-803.
5. Jerala, R., Trstenjak, M., Lenarčič, B. and Turk, V. (1988). Cloning a synthetic gene for human stefin B and its expression in E. coli. FEBS Lett. 239, 41-44.
6. Katunuma, N., Murata, E., Kakegawa, H., Matsui, A., Tsuzuki, H., Tsuge, H., Turk, D., Turk, V., Fukushima, M., Tada, Y. and Asao, T. (1999). Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo. FEBS Lett. 458, 6-10.
7. Kopitar, G., Dolinar, M., Štrukelj, B., Pungerčar, J. and Turk V. (1996). Folding and activation of human procathepsin S from inclusion bodies produced in Escherichia coli. Eur. J. Biochem. 236, 558-562.
8. Korant, B.D., Towatari, T., Ivanoff, L., Petteway, S., Brzin, J., Lenarčič, B. and Turk, V. (1986). Viral therapy: prospects for proteinase inhibitors. J. Cell. Biochem. 32, 91-95.
9. Kuhelj, R., Dolinar, M., Pungerčar, J. and Turk, V. (1995). The preparation of catalytically active human cathepsin B from its precursor expressed in Escherichia coli in the form of inclusion bodies. Eur. J. Biochem. 229, 533-539.
10. Lenarčič, B. and Turk, V. (1999). Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D. J. Biol. Chem. 274, 563-566.
11. Lenarčič, B., Ritonja, A., Štrukelj, B., Turk, B., and Turk, V. (1997). Equistatin, a new protein inhibitor of cysteine proteinases from Actinia equina is structurally related to thyroglobulin type-1 domain. J. Biol. Chem. 272, 13899-13903.
12. Machleidt, W., Borchart, U., Fritz, H., Brzin, J., Ritonja, A. and Turk, V. (1983). Protein inhibitors of cysteine proteinases II. Primary structure of stefin, a cytosolic protein inhibitor of cysteine proteinases from human polymorphonuclear granulocytes. Hoppe-Seyler's Z. Physiol. Chem. 364, 1481-1486.
13. Müller-Esterl, W., Fritz, H., Machleidt, W., Ritonja, A., Brzin, J., Kotnik, M., Turk, V., Kellermann, J. and Lottspeich, F. (1985). Human plasma kininogens are identical with à-cysteine proteinase inhibitors. Evidence from immunological, enzymological and sequence data. FEBS Lett. 182, 310-314.
14. Musil, D., Zučič, D., Turk, D., Engh, R. A., Mayr, I., Huber, R., Popovič, T., Turk, V., Towatari, T., Katunuma, N. and Bode, W. (1991). The refined 2.15 Å X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. EMBO J. 10, 2321-2330.
15. Ogrinc, T., Dolenc, I., Ritonja, A. and Turk V. (1993). Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney. FEBS Lett. 336, 555-559.
16. Pariš, A., Štrukelj, B., Pungerčar, J., Renko, M., Dolenc, I. and Turk, V. (1995). Molecular cloning and sequence analysis of human preprocathepsin C. FEBS Lett. 369, 326-330.
17. Ritonja, A., Popovič, T., Turk, V., Wiedenmann, K. and Machleidt, W. (1985). Amino acid sequence of human liver cathepsin B. FEBS Lett. 181, 169-172.
18. Ritonja, A., Popovič, T., Kotnik, M., Machleidt, W. and Turk, V. (1988). Amino acid sequence of the human kidney cathepsins H and L. FEBS Lett. 228, 341-345.
19. Rozman-Pungerčar, J., Kopitar-Jerala, N., Bogyo, M., Turk, D., Vasiljeva, O., Štefe, I., Vandenabeele, P., Brömme, D., Puizdar, V., Fonovič, M. et al. (2003). Inhibition of papain-like cysteine proteases and legumain by 'caspase-specific' inhibitors: when reaction mechanism is more important than specificity. Cell Death Diff., in press.
20. Stoka, V., Turk, B., Schendel, S., Cirman, T., Snipas, S.J., Ellerby, L., Bredesen, D., Freeze, H., Abrahamson, M., Brömme, D. et al. (2001). Lysosomal protease pathways to apoptosis: cleavage of BID, not pro-caspases, is the most likely route. J. Biol. Chem. 276, 3149-3157.
21. Stubbs, M.T., Laber, B., Bode, W., Huber, R., Jerala, R., Lenarčič, B. and Turk, V. (1990). The refined 2.4 Å X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. EMBO J. 9, 1939-1947.
22. Tsuge, H., Nishimura, T., Tada, Y., Asao, T., Turk, D., Turk, V. and Katunuma, N. (1999). Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex. Biochem. Biophys. Res. Commun. 266, 411-416.
23. Turk, B., Stoka, V., Björk, I., Boudier, C., Johansson, G., Dolenc, I., Čolić, A., Bieth, J.G. and Turk, V. (1995a . High-affinity binding of two molecules of cysteine proteinases to low-molecular-weight kininogen. Protein Sci. 4, 1874-1880.
24. Turk, D., Podobnik, M., Popović, T., Katunuma, N., Bode, W., Huber, R. and Turk, V. (1995b). Crystal structure of cathepsin B inhibited with CA030 at 2.0-Å resolution: a basis for the design of specific epoxysuccinyl inhibitors. Biochemistry 34, 4791-4797.
25. Turk, D., Podobnik, M., Kuhelj, R., Dolinar, M. and Turk, V. (1996). Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide. FEBS Lett. 384, 211-214.
26. Turk, D., Janjić, V., Štern, I., Podobnik, M., Lamba, D., Dahl, S.W., Lauritzen, C., Pedersen, J., Turk, V. and Turk, B. (2001). Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases. EMBO J. 20, 6570-6582.
27. Turk, V., Brzin, J., Longer, M., Ritonja, A., Eropkin, M., Borchart, U. and Machleidt, W. (1983). Protein inhibitors of cysteine proteinases III. Amino acid sequence of cystatin from chicken egg white. Hoppe-Seyler's Z. Physiol. Chem. 364, 1487-1496.
28. Turnšek, T., Kregar, I. and Lebez, D. (1975). Acid sulphydryl protease from calf lymph nodes. Biochim. Biophys. Acta 403, 514-520.
29. Turnšek, T., Kregar, I., Lebez, D. and Turk, V. (1977). A thiol dependent acid protease. In: Intracellular Protein Catabolism II, V. Turk and N. Marks, eds. (New York, USA: Plenum Press), pp. 290-298.