Motor timing deficits in community and clinical boys with hyperactive behavior: The effect of methylphenidate on motor timing

Journal of Abnormal Child Psychology

Volumn 31, Issue 3, 2003, Pages 301-313

  Rubia, Katya ^a,d   Noorloos, Janet ^c   Smith, Anna ^a   Gunning, Boudewijn ^c   Sergeant, Joseph ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Attention deficit hyperactivity disorder (ADHD); Methylphenidate; Motor timing; Ritalin; Time estimation; Time perception

Indexed keywords

METHYLPHENIDATE; PLACEBO;

AGGRESSION; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELINQUENCY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FOLLOW UP; HUMAN; MALE; MOTOR ACTIVITY; SCHOOL CHILD; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; TIME SERIES ANALYSIS;

ANALYSIS OF VARIANCE; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; CROSS-OVER STUDIES; DISCRIMINATION (PSYCHOLOGY); DOUBLE-BLIND METHOD; HUMANS; MALE; METHYLPHENIDATE; MOTOR SKILLS; RESIDENCE CHARACTERISTICS; TIME PERCEPTION;

EID: 0038136656     PISSN: 00910627     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023233630774     Document Type: Article

References (81)

1. Achenbach, T. (1994). Manual for the child behavior checklist/4-18 and 1991 profile. Burlington: University of Vermont.
2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
3. Barkley, R. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65-94.
4. Barkley, R. A., Koplowitz, S., Anderson, T., & McMurray, M. B. (1997). Sense of time in children with ADHD: Effects of duration, distraction, and stimulant medication. Journal of International Neuropsychological Society, 3, 359-369.
5. Berman, T., Douglas, V. I., & Barr, R. G. (1999). Effects of methylphenidate on complex cognitive processing in attentiondeficit hyperactivity disorder. Journal of Abnormal Psychology, 108, 90-105.
6. Biederman, J., & Spencer, T. (1999). Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological Psychiatry, 46, 1234-1242.
7. Butte, N., Treuth, M., Voigt, R., Llorente, A., & Heird, W. (1999). Stimulant medications decrease energy expenditure and physical activity in children with attention deficit/hyperactivity disorder. Journal of Pediatrics, 135, 203-207.
8. Carte, E. T., Nigg, J. T., & Hinshaw, S. P. (1996). Neuropsychological functioning, motor speed, and language processing in boys with and without ADHD. Journal of Abnormal Child Psychology, 24, 481-498.
9. Daugherty, T. K., Quay, H. C., & Ramos, L. (1993). Response perseveration, inhibitory control, and central dopaminergic activity in childhood behavior disorders. Journal of Genetic Psychology, 154, 177-188.
10. Denckla, M. B., Rudel, R. G., Chapman, C., & Krieger, J. (1985). Motor proficiency in dyslexic children with and without attentional disorders. Archives of Neurology, 42, 228-231.
11. Dougherty, D., Bonab, A., Spencer, T., Rauch, S., Madras, B., & Fischman, A. (2000). Dopamine-transporter density in patients with ADHD-Reply. Lancet, 355, 1461-1462.
12. Fergusson, D. M., Horwood, L. J., & Lloyd, M. (1991). Confirmatory factor models of attention and conduct disorder. Journal of Child Psychology and Psychiatry, 32, 257-274.
13. Fuster, J. M. (1985). Temporal organization of behavior. Human Neurobiology, 4, 57-60.
14. Gainetdinov, R., Wetsel, W., Jones, S., Levin, E., Jaber, M., & Caron, M. (1999). Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science, 283, 397-400.
15. Gerralda, M. E., & Bailey, D. (1988). Child and family factors associated with referral to child psychiatrists. British Journal of Psychology, 9, 213-227.
16. Greenhill, L. L., Swanson, J. M., Vitiello, B. V., Davies, M., Clevenger, W., Wu, M., et al. (2001). Impairment and deportment responses to different methylphenidate doses in children with ADHD: The MTA titration trial. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 180-187.
17. Groth-Marnat, G. (1990). Handbook of psychological assessment: The Wechsler intelligence scales (2nd ed., Vol. 5). New York: Wiley.
18. Ivry, R. B. (1996). The representation of temporal information in perception and motor control. Current Opinion in Neurobiology, 6, 851-857.
19. Klorman, R., Brumaghim, J. T., Fitzpatrick, P. A., & Borgstedt, A. D. (1991). Methylphenidate speeds evaluation processes of attentiondeficit disorder adolescents during a Continuous Performance-Test. Journal of Abnormal Child Psychology, 19, 263-283.
20. Krause, K.-H., Dresel, S., Krause, J., Kung, H., & Tatsch, K. (2000). Incrased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomography. Neuroscience Letters, 285, 107-110.
21. Le Moal, A. (1995). Mesocorticolimbic dopaminergic neurons: Functional and regulatory roles. In F. Bloom & D. J. Kupfer (Eds.), Psychopharmacology: The fourth generation of progress (pp. 283-294). New York: Raven Press. An Official Publication of the American College of Neuropsychopharmacology.
22. Leth-Steensen, C., Elbaz, Z. K., & Douglas, V. I. (2000). Mean response times, variability and skew in the responding of ADHD children: A response time distributional approach. Acta Psychologica, 104, 167-190.
23. Maddock, J. E., Rossi, J. S., & Joseph, S. (2001). Statistical power of articles published in three health-psychology related journals. Health Psychology, 20, 76-78.
24. Mates, J. (1990). A system of personal computer control programs for tapping experiments. Computer Methods and Programs in Biomedicine, 33, 43-48.
25. Mates, J., Radil, T., & Poeppel, E. (1992). Cooperative tapping: Time control under different feedback conditions. Perception and Psychophysics, 52, 691-704.
26. Meck, W. (1996). Neuropharmacology of timing and time perception. Cognitive Brain Research, 3, 227-242.
27. Milich, R., Hartung, C. M., Martin, C. A., & Haigler, E. D. (1995). Disinhibition and underlying processes in hyperactive and aggressive adolescents. In D. K. Routh (Ed.), Disruptive behavior disorder in childhood: Essays honoring Herbert C. Quay (pp. 109-139). New York: Plenum.
28. Miller, G. A., & Chapman, J. P. (2001). Misunderstanding analysis of covariance. Journal of Abnormal Psychology, 110, 40-48.
29. National Institute of Mental Health (NIMH). (1992). Diagnostic Interview Schedule for Children (DISC) Version 2.3. New York: New York Psychiatric Institute. Division of Child and Adolescent Psychiatry.
30. Nicolson, R. I., Fawcett, A. J., & Dean, P. (1995). Time estimation deficits in developmental dyslexia: Evidence of cerebellar involvement. Proceedings of the Royal Society London: Brain and Biological Science, 259, 43-47.
31. Oades, R. (2000). Differential measures of "sustained attention" in children with attention-deficit/hyperactivity or tic disorders: Relations to monoamine metabolism. Psychiatry Research, 93, 165-178.
32. O'Toole, K., Abramowitz, A., Morris, R., & Dulcan, M. (1997). Effects of methylphenidate on attention and nonverbal learning in children with attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 531-538.
33. Pelham, W., Hoza, B., Kipp, H., Gnagy, E., & Trane, S. (1997). Effects of methylphenidate and expectancy of ADHD children's performance, self-evaluations, persistence, and attributions on a cognitive task. Experimental and Clinical Psychopharmacology, 5, 3-13.
34. Pennington, B. F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37, 51-87.
35. Piek, J. P., & Skinner, R. A. (1999). Timing and force control during a sequential tapping task in children with and without motor coordination problems. Journal of the International Neuropsychological Society, 5, 320-329.
36. Robaey P., Breton, F., Dugas, M., & Renault, B. (1992). An event-related study of controlled and automatic processes in 6-8-year-old boys with attention deficit hyperactivity disorder. Electroencephalography and Clinical Neurophysiology, 82, 330-340.
37. Rubia, K. (2002). The dynamic approach to neurodevelopmental psychiatric disorders: Use of fMRI combined with neuropsychology to elucidate the dynamics of psychiatric disorders, exemplified in ADHD and schizophrenia. Behavioral Brain Research, 130, 47-56.
38. Rubia, K., Oosterlaan, J., Sergeant, J. A., Brandeis, D., & van Leeuwen, T. (1998a). Inhibitory dysfunction in hyperactive boys. Behavioral Brain Research, 94, 25-32.
39. Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S., Simmons, A., et al. (1998b). Prefrontal involvement in "temporal bridging" and timing movement. Neuropsychologia, 36, 1283-1293.
40. Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S., Simmons, A., et al. (1999a). Hypofrontality in attention deficit hyperactivity disorder during higher order motor control: A study with fMRI. American Journal of Psychiatry, 156, 891-896.
41. Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S. C. R., Simmons, A., et al. (2000). Functional frontalisation with age: Mapping neurodevelopmental trajectories with fMRI. Neuroscience and Biobehavioral Reviews, 24, 13-19.
42. Rubia, K., Russell, T., Overmeyer, S., Brammer, M. J., Bullmore, E. T., Sharma, T., et al. (2001a). Mapping motor inhibition: Conjunctive brain activations across different versions of go/no-go and stop tasks. NeuroImage, 13, 250-261.
43. Rubia, K., Schuri, U., von Cramon, D., & Poeppel, E. (1997). Time estimation as a neuronal network property: A lesion study. NeuroReport, 8, 1273-1276.
44. Rubia, K., & Smith, A. (2001). Attention deficit-hyperactivity disorder: current findings and treatment. Current Opinion in Psychiatry, 4, 309-316.
45. Rubia, K., Taylor, E., Smith, A., Oksanen, H., Overmeyer, S., & Newman, S. (2001b). Neuropsychological analyses of impulsiveness in childhood hyperactivity. British Journal of Psychiatry, 179, 138-143.
46. Rubia, K., Taylor, A., Taylor, E., & Sergeant, J. (1999b). Synchronization, anticipation, and consistency in motor timing of children with dimensionally defined attention deficit hyperactivity behavior. Perceptual and Motor Skills, 89, 1237-1258.
47. Schachar, R., Tannock, R., Cunningham, C., & Corkum, P. (1997). Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 754-763.
48. Schachar, R., Tannock, R., Marriot, M., & Logan, G. (1995). Deficient inhibitory control in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 23, 411-437.
49. Schweitzer, J. B., & Sulzer-Azaroff, B. (1995). Self-control in boys with attention-deficit-hyperactivity-disorder: Effects of added stimulation and time. Journal of Child Psychology and Psychiatry, 36, 671-686.
50. Smith, A. (2002). Time estimation and discrimination in children with hyperactivity. Doctoral dissertation, University of London, London.
51. Smith, B., Pelham, W., Evans, S., Gnagy, E., Molina, B., Bukstein, O., et al. (1998). Dosage effects of methylphenidate on the social behavior of adolescents diagnosed with attention-deficit hyperactivity disorder. Experimental and Clinical Psychopharmacology, 6, 187-204.
52. Smith, A., Taylor, E., Warner-Rogers, J., Taylor, A., & Rubia, K. (2002). Evidence for a time perception deficit in children with ADHD. Journal of Child and Adolescent Psychiatry, 43, 529-542.
53. Solanto, M. V. (1998). Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: A review and integration. Behavioral Brain Research, 94, 127-152.
54. Solanto, M. V., & Wender, E. H. (1989). Does methylphenidate constrict cognitive-functioning? Journal of the American Academy of Child and Adolescent Psychiatry, 28, 897-902.
55. Sonneville, L. M. J., Njiokiktjien, C., & Hilhorst, R. C. (1991). Methylphenidate-induced changes in ADHD information processing. Journal of Child Psychology and Psychiatry, 32, 285-295.
56. Sonuga-Barke, E., Saxton, T., & Hall, M. (1998). The role of interval underestimation in hyperactive children's failure to suppress responses over time. Behavioral Brain Research, 94, 45-50.
57. Sonuga-Barke, E.J.S., Taylor, E., Sembi, S., & Smith, J. (1992). Hyperactivity and delay aversion - I. The effect of delay on choice. Journal of Child Psychology and Psychiatry, 33, 387-398.
58. Spivak, B., Vered, Y., Yoran-Hegesh, R., Averbuch, E., Vinokurow, S., Weizman, A., et al. (2001), The influence of three months of methylphenidate treatment on platelet-poor plasma biogenic amine levels in boys with attention deficit hyperactivity disorder. Human Psychopharmacology - Clinical and Experimental, 16, 333-337.
59. Sproson, E. J., Chantrey, J., Hollis, C., Marsden, C. A., & Fone, K. C. F. (2001). Effect of methylphenidate administration on presynaptic dopamine and behavior in young adult rats. Journal of Psychopharmacology, 15, 67-75.
60. SPSS Inc. (1994). SPSSfor Windows V 6.1 (Version 6.1). Chicago, IL: Author.
61. Steger, J., Imhof, G., Coutts, E., Gundelfinger, R., Steinhausen, E.C., & Brandeis, D. (2001) Attentional and neuromotor deficits in ADHD. Developmental Medicine and Child Neurology, 43, 172-179.
62. Stevens, D. A., Stover, C. E., & Backus, J. T. (1970). The hyperkinetic child: Effect of incentives on the speed of rapid tapping. Journal of Consulting and Clinical Psychology, 34, 56-59.
63. Sykes, D. H., Douglas, V. I., & Morgenstern, G. (1973). Sustained attention in hyperactive children. Journal of Child Psychology and Psychiatry, 14, 213-220.
64. Sykes, D. H., Douglas, V. I., Weiss, G., & Minde, K. K. (1971). Attention in hyperactive children and the effect of methylphenidate (ritalin). Journal of Child Psychology and Psychiatry, 12, 129-139.
65. Tannock, R., Ickowicz, A., & Schachar, R. (1995a). Differential-effects of methylphenidate on working-memory in ADHD children with and without comorbid anxiety. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 886-896.
66. Tannock, R., Schachar, R., Carr, R. P., Chajczyk, R. P., & Logan, G. D. (1989). Effect of methylphenidate on inhibitory control in hyperactive children. Journal of Abnormal Child Psychology, 17, 473-491.
67. Tannock, R., Schachar, R., & Logan, G. (1995b). Methylphenidate and cognitive flexibility: Dissociated dose effects in hyperactive children. Journal of Abnormal Child Psychology, 23, 235-266.
68. Taylor, E., Chadwick, O., Heptinstall, E., & Danckaerts, M. (1996). Hyperactivity and conduct problems as risk factors for adolescent development. Journal of the American Academy of Child Psychiatry, 35, 1213-1226.
69. Teicher, M., Anderson, C., Polcari, A., Glod, C., Maas, L., & Renshaw, P. (2000). Functional deficits in basal ganglia of children with attention deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry. Nature Medicine, 6, 470-473.
70. Thurston, C., Sobol, M. P., Swanson, J., & Kinsbourne, M. (1991). Effects of methylphenidate (Ritalin) on selective attention in hyperactive children. Journal of Abnormal Child Psychology, 7, 471-481.
71. Trommer, B. L., Hoeppner, J. A. B., & Zecker, S. G. (1991). The gono-go test in attention deficit hyperactivity disorder is sensitive to methylphenidate. Journal of Child Neurology, 6, S128-S131.
72. Vaidya, C., Austin, G., Kirkorian, G., Ridlehuber, H., Desmond, J., Glover, G., et al. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study. Procedures of the National Academy of Science, 95, 14494-14499.
73. van der Meere, J., Vreeling, H. J., & Sergeant, J. (1992). A motor presetting study in hyperactive, learning disabled and control children. Journal of Child Psychology and Psychiatry, 33, 1347-1354.
74. Verbaten, M. N., Overtoom, C. C. E., Koelega, H. S., Swaab-Barneveld, H., van der Gaag, R. J., Buitelaar, J., et al. (1994). Methylphenidate influences both early and late ERP waves of ADHD children in a Continuous Performance Test. Journal of Abnormal Child Psychology, 22, 561-578.
75. Volkow, N., Gur, R., Wang, G., Fowler, J., Moberg, P., Ding, Y.-S., et al. (1998). Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. American Journal of Psychiatry, 155, 344-349.
76. Volkow, N., Wang, G., Fowler, J., Logan, J., Angrist, B., Hitzemann, R., et al. (1997). Effects of methylphenidate on regional brain glucose metabolism in humans: Relationship to dopamine D2 receptors. American Journal of Psychiatry, 154, 50-55.
77. Vongher, J. M., Vassileva, J. L., Fischer, M., Conant, L., Risinger, R. C., Salmeron, B. J., et al. (2001). Behavioral inhibition and motor timing in ADHD adults. Brain and Cognition, 47, 219-222.
78. Waber, D. P., Weiler, M. D., Bellinger, D. C., Marcus, D. J., Forbes, P. W., Wypij, D., et al. (2000). Diminished motor timing control in children referred for diagnosis of learning problems. Developmental Neuropsychology, 17, 181-97.
79. Wilkison, P. C., Kircher, J. C., McMahon, W. M., & Sloane, H. N. (1995). Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder. Journal of American Academy of Child and Adolescent Psychiatry, 34, 897-900.
80. Woodward, L., Dowdney, L., & Taylor, E. (1997). Child and family factors influencing the clinical referral of children with hyperactivity: A research note. Journal of Child Psychology and Psychiatry, 38, 479-485.
81. Zackay, D. (1990). The evasive art of subjective time measurement. In R. A. Block (Ed.), Cognitive models of psychological time (pp. 59-84). Hillsdale, NJ: Lawrence Erlbaum.