Effects of methylphenidate on regional brain glucose metabolism in humans: Relationship to dopamine D2 receptors

American Journal of Psychiatry

Volumn 154, Issue 1, 1997, Pages 50-55

  Volkow, Nora D ^a   Wang, Gene Jack ^b   Fowler, Joanna S ^b   Logan, Jean ^b   Angrist, Burton ^b   Hitzemann, Robert ^b   Lieberman, Jeffrey ^b   Pappas, Naomi ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DOPAMINE 2 RECEPTOR; GLUCOSE; METHYLPHENIDATE; PLACEBO; RACLOPRIDE;

ADULT; ARTICLE; BRAIN METABOLISM; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DOPAMINE BLOOD LEVEL; DOSE RESPONSE; DRUG ABUSE; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SYMPTOMATOLOGY;

EID: 0031032748     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.1.50     Document Type: Article

References (41)

1. LeMoal M, Simon H: Mesocorticolimbic dopamine network: functional and regulatory roles. Physiol Rev 1991; 71:155-234
2. Volkow ND, Fowler JS, Gatley JS, Logan J, Wang G-J, Ding Y-S, Dewey SL: PET evaluation of the dopamine system of the human brain. J Nucl Med 1996; 37:1242-1256
3. Wolkin A, Sanfilipo M, Duncan E, Angrist B, Wolf AP, Cooper TB, Brodie JD, Laska E, Rotrosen JP: Blunted change in cerebral glucose utilization after haloperidol treatment in schizophrenic patients with prominent negative symptoms. Am J Psychiatry 1996; 153:346-354
4. Reivich M, Alavi A, Wolf A, Greenberg JH, Fowler JS, MacGregor R, Jones SC, London J, Shive C, Yonekura T: Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for 18F-fluorodeoxyglucose and 11C-deoxyglucose. J Cereb Blood Flow Metab 1985; 5:179-192
5. Volkow ND, Wang G-J, Fowler JS, Logan J, Schlyer D, Hitzemann R, Lieberman J, Angrist B, Pappas N, MacGregor R, Burr G, Cooper T, Wolf AP: Imaging endogenous dopamine competition with [11C]raclopride in the human brain, Synapse 1994; 16:255-262
6. Joyce PR, Donald RA, Nicholls MG, Lievesey JH, Abbott RM: Endocrine and behavioral responses to methylphenidate in normal subjects. Biol Psychiatry 1986; 21:1015-1023
7. Chait LD: Reinforcing and subjective effects of methylphenidate in humans. Behav Pharmacol 1994; 5:281-288
8. Volkow ND, Ding U, Fowler JS, Wang G-J, Logan J, Gatley JS, Dewey SL, Ashby C, Lieberman J, Hitzemann R, Wolf AP: Is methylphenidate like cocaine? studies on their pharmacokinetics and distribution in human brain. Arch Gen Psychiatry 1995; 52: 456-463
9. Wang G-J, Volkow ND, Hitzemann R, Wong C, Angrist B, Burr G, Pascani K, Pappas N, Lu A, Cooper T, Lieberman J: Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers. Eur Addiction Res (in press)
10. Volkow ND, Fowler JS, Wang G-J, Dewey SL, Schlyer D, MacGregor R, Logan J, Alexoff D, Shea C, Hitzemann R, Angrist B, Wolf AP: Reproducibility of repeated measures of 11C raclopride binding in the human brain. J Nucl Med 1993; 34:609-613
11. Wang G-J, Volkow ND, Roque C, Cestaro V, Hitzemann R, Cantos E, Levy AV, Wolf AP: Functional significance of ventricular enlargement and cortical atrophy in normals and alcoholics as assessed by PET, MRI and neuropsychological testing. Radiology 1992; 186:59-65
12. Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer D, MacGregor RR, Hitzemann R, Bendriem B, Gatley SJ, Christman DR: Graphical analysis of reversible binding from time activity measurements. J Cereb Blood Flow Metab 1990; 10:740-747
13. Logan J, Volkow ND, Fowler JS, Wang G-J, Dewey SL, MacGregor R, Schlyer D, Gatley SJ, Pappas N, King P, Hitzemann R, Vitkun S: Effects of blood flow on [11C]raclopride binding in the brain: model simulations and kinetic analysis of PET data. J Cereb Blood Flow Metab 1994; 14:995-1010
14. Kirk RE: Introductory Statistics. Belmont, Calif, Brooks/Cole, 1978
15. Volkow ND, Brodie JD, Wolf AP, Gomez-Mont F, Cancro R, Van Gelder P, Russell JAG, Overall J: Brain organization of schizophrenics. J Cereb Blood Flow Metab 1986; 6:441-446
16. Cohen JC, Servan-Schreiber D: Context, cortex and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol Rev 1992; 99:45-77
17. Deminiere IM, Piazza PV, Le Moal M, Simon H: Experimental approach to individual vulnerability to psychostimulant addiction. Neurosci Biobehav Rev 1989; 13:141-147
18. Hooks MS, Jones GH, Smith AD, Neill DB, Justice JB: Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse 1991; 9:121-128
19. Weber K: Methylphenidate: rate dependent drug effects in hyperactive boys. Psychopharmacology (Berl) 1985; 85:231-235
20. Castellanos XF, Elia J, Kruesi MJP, Marsh WL, Gulotta CS, Potter WZ, Ritchie GF, Hamburger SD, Rapoport JL: Cerebrospinal fluid homovanillic acid predicts behavioral responses to stimulant in 47 boys with attention deficit hyperactivity disorder. Neuropsychopharmacology 1996; 14:125-137
21. van Kammen DP, Bunney WE Jr, Docherty JP, Marder SR, Ebert MH, Rosenblatt JE, Rayner J: d-Amphetamine-induced heterogeneous changes in psychotic behavior in schizophrenia. Am J Psychiatry 1982; 139:991-997
22. Lieberman JA, Alvir J, Geisler S, Ramos-Lorenzi J, Woerner M, Novacenko H, Cooper T, Kane JM: Methylphenidate response, psychopathology and tardive dyskinesia as predictors of relapse in schizophrenia. Neuropsychopharmacology 1994; 11:107-118
23. Schwartz WJ, Smith CB, Davidsen L, Savaki H, Sokoloff L, Mata M, Fink DJ, Gainer H: Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science 1979; 205:723-725
24. Hall H, Sedvall G, Magnusson O, Kopp J, Halldin C, Farde L: Distribution of D1 and D2-dopamine receptors, and dopamine and its metabolites in the human brain. Neuropsychopharmacology 1994; 11:245-256
25. Patrick KS, Caldwell RW, Ferris RM, Breese GR: Pharmacology of the enantiomers of threo-methylphenidate. J Pharmacol Exp Ther 1987; 241:152-158
26. McCulloch J, Savaki HE, McCulloch MC, Jehle J, Sokoloff L: The distribution of alterations in energy metabolism in the rat brain produced by apomorphine. Brain Res 1982; 243:67-80
27. Pontieri FE, Mainero C, La Riccia C, Passarelli F, Orzi F: Functional correlates of repeated administration of cocaine and apomorphine in the rat. Eur J Pharmacol 1995; 284:205-209
28. Volkow ND, Levy A, Brodie JD, Wolf AP, Cancro R, Van Gelder P, Henn F: Low cerebellar metabolism in medicated patients with chronic schizophrenia. Am J Psychiatry 1992; 149:686-688
29. Leiner HC, Leiner AL, Dow RS: Reappraising the cerebellum: what does the hindbrain contribute to the forebrain? Behav Neurosci 1989; 103:998-1008
30. Andreasen NC, O'Leary DS, Arndt S, Cizadlo T, Hurtig R, Rezai K, Watkins GL, Ponto LL, Hichwa RD: Short-term and long-term verbal memory: a positron emission tomography study. Proc Natl Acad Sci USA 1995; 92:5111-5115
31. Barkley RA, Grodzinsky G, Du Paul GJ: Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report. J Abnorm Child Psychol 1992; 20: 163-188
32. Wilens TE, Biederman J: The stimulants. Pediatric Psychopharmacology 1992; 15:191-222
33. Gaddes WH: Learning Disabilities and Brain Function. New York, Springer-Verlag, 1985
34. Hitzemann R, Qian Y, Kanes S, Dains K, Hitzemann B: Genetics and the organization of the basal ganglia. Int Rev Neurobiol 1995; 38:43-94
35. Matochik JA, Nordahl TE, Gross M, Semple WE, King CA, Cohen RM, Zametkin AJ: Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology 1993; 8:377-386
36. London ED, Cascella NG, Wong DF, Phillips RL, Dannals RF, Links JM, Herning R, Grayson R, Jaffe JH, Wagner HN: Cocaine-induced reduction of glucose utilization in human brain: a study using positron emission tomography and [fluorine-18]-fluorodeoxyglucose. Arch Gen Psychiatry 1990; 47:567-574
37. Porrino LJ, Lucignani G: Different patterns of local brain energy metabolism associated with high and low doses of methylphenidate: relevance to its action in hyperactive children. Biol Psychiatry 1987; 22:126-138
38. London ED, Wilkerson G, Ori C, Kimes AS: Central action of psychostimulants on glucose utilization in extrapyramidal motor areas of the rat brain. Brain Res 1990; 512:155-158
39. Grace AA: The tonic/phasic model of dopamine system regulation: its relevance for understanding how stimulant abuse can alter basal ganglia function. Drug Alcohol Depend 1995; 37: 111-129
40. Srinivas N, Hubbard J, Korchinski E, Midha K: Enantioselective pharmacokinetics of d,l-threo-methylphenidate in humans. Pharm Res 1993; 10:14-21
41. Wang G-J, Volkow ND, Overall J, Hitzemann RJ, Pappas N, Pascani K, Fowler JS: Reproducibility of regional brain metabolic responses to lorazepam. J Nucl Med 1996; 37:1609-1613