Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate Derivatives and evaluation of their antimalarial activities

Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2003, Pages 2397-2403

  Ningsanont, Nongpanga ^a   Black, David St C ^b   Chanphen, Rachada ^c   Thebtaranonth, Yodhathai ^a,c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CARBOXYLIC ACID DERIVATIVE; ETHYL 2 (2 METHOXYCARBONYLCYCLOPROPYL) 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 2 (3 PHENYLPROPYL) 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 2 [2 (1,3 DIOXOLAN 2 YL)ETHYL] 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 2 BUTYL 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 2 METHYL 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 2 PENTYL 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 2 PROPYL 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE; ETHYL 5 PHENYL 6 OXA 1 AZABICYCLO[3.1.0]HEXANE 2 CARBOXYLATE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL BINDING; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PLASMODIUM FALCIPARUM; REACTION ANALYSIS; VERO CELL;

ANIMALS; ANTIMALARIALS; ANTITUBERCULAR AGENTS; AZA COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; CERCOPITHECUS AETHIOPS; CHLOROQUINE; DRUG RESISTANCE, MULTIPLE; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 0038101387     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020452h     Document Type: Article

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