Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase IIα

Molecular Pharmacology

Volumn 63, Issue 5, 2003, Pages 1159-1168

  Renodon Cornière, Axelle ^a   Sørensen, Tina K ^a,c   Jensen, Peter B ^a,c   Nitiss, John L ^b   Søkilde, Birgitte ^c   Sehested, Maxwell ^a,c   Jensen, Lars H ^a,c  

^a University of Copenhagen   (Denmark)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c BioAlliance Pharma   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS(3,5 DIOXOPIPERAZIN 1 YL)ETHANE; DNA TOPOISOMERASE (ATP HYDROLYSING); MITINDOMIDE; PIPERAZINE DERIVATIVE; PIPERAZINEDIONE;

ARTICLE; CHROMATIN CONDENSATION; COMPLEX FORMATION; DNA DAMAGE; DNA RECOMBINATION; DNA REPLICATION; DRUG ACTIVITY; GENE MUTATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TARGET CELL;

ADENOSINE TRIPHOSPHATE; ANTIGENS, NEOPLASM; CATALYSIS; DNA; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENETIC COMPLEMENTATION TEST; HUMANS; INDOLES; MUTAGENESIS, SITE-DIRECTED; PIPERAZINES; RAZOXANE; YEASTS;

EID: 0038068957     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.5.1159     Document Type: Article

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