Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase IIα

FEBS Letters

Volumn 520, Issue 1-3, 2002, Pages 161-166

  Wessel, Irene ^a   Jensen, Lars H ^a   Renodon Corniere, Axelle ^a   Sorensen, Tina K ^a   Nitiss, John L ^c   Jensen, Peter B ^b   Sehested, Maxwell ^a  

^a Rigshospitalet   (Denmark)

^b FINSEN LABORATORY   (Denmark)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Bisdioxopiperazine; Drug resistance; Mutation; Topoisomerase II

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA TOPOISOMERASE (ATP HYDROLYSING); KINETOPLAST DNA; RAZOXANE;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HYDROLYSIS; LUNG SMALL CELL CANCER; PHARMACOPHORE; PLASMID; POINT MUTATION; PRIORITY JOURNAL; WILD TYPE; YEAST;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BINDING SITES; CARCINOMA, SMALL CELL; CELL DIVISION; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, FUNGAL; DRUG RESISTANCE, NEOPLASM; GENOTYPE; HUMANS; LUNG NEOPLASMS; MUTATION; PROTEIN BINDING; RAZOXANE; SACCHAROMYCES CEREVISIAE; TRANSFORMATION, GENETIC; TUMOR CELLS, CULTURED;

STAPHYLOCOCCUS PHAGE 187;

EID: 0037024363     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)02805-3     Document Type: Article

References (20)