N-terminal and core-domain random mutations in human topoisomerase II α conferring bisdioxopiperazine resistance

FEBS Letters

Volumn 480, Issue 2-3, 2000, Pages 201-207

  Jensen, Lars H ^a,b   Wessel, Irene ^a   Møller, Marianne ^a   Nitiss, John L ^c   Sehested, Maxwell ^a   Jensen, Peter B ^b  

^a Department of Pathology   (Denmark)

^b FINSEN LABORATORY   (Denmark)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Bisdioxopiperazine resistance; Human topoisomerase II ; Mutation

Indexed keywords

ACLARUBICIN; DNA TOPOISOMERASE (ATP HYDROLYSING); MERBARONE; PIPERAZINE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CLONOGENIC ASSAY; CYTOTOXICITY; DNA HELIX; DNA STRAND BREAKAGE; GENE MUTATION; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PURIFICATION;

ADENOSINE TRIPHOSPHATE; AMSACRINE; ANTIGENS, NEOPLASM; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; DRUG RESISTANCE; ENZYME INHIBITORS; ETOPOSIDE; HUMANS; ISOENZYMES; MUTAGENESIS; NUCLEIC ACID SYNTHESIS INHIBITORS; PIPERAZINES; RAZOXANE;

EID: 0034284722     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01934-7     Document Type: Article

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