Significance of intracellular Aβ in Alzheimer's disease

Japanese Journal of Neuropsychopharmacology

Volumn 22, Issue 5, 2002, Pages 175-180

  Tabira, Takeshi ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Alzheimer's disease; Amyloid; Apoptosis; Presenilin; Senile plaque

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN 1; AMYLOID BETA PROTEIN (10 43); AMYLOID BETA-PROTEIN (10-43); MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; APOPTOSIS; AUTOPSY; BRAIN BLOOD VESSEL; DEMENTIA; DISEASE SEVERITY; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; NEUROPATHOLOGY; NICK END LABELING; NONHUMAN; PATHOGENESIS; SENILE PLAQUE; SHORT SURVEY; SYNAPSE; TRANSGENIC MOUSE; ANIMAL; BRAIN; GENETICS; METABOLISM; MOUSE; NERVE CELL; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BRAIN; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NEURONS; PEPTIDE FRAGMENTS; PRESENILIN-1; SENILE PLAQUES;

EID: 0037836969     PISSN: 13402544     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (17)

1. Chui, D. H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., Takahashi, K., Gallyas, F. and Tabira, T. (1999) Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med, 5: 560-564.
2. Chui, D. H., Dobo, E., Makifuchi, T., Akiyama, H., Kawakatsu, S., Petit, A., Checler, F., Araki, W.; Takahashi, K. and Tabira, T. (2001) Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling. J Alzheimer Dis, 3: 231-239.
3. Cook, D. G., Forman, M. S., Sung, J. C., Leight, S., Kolson, D. L., Iwatsubo, T., Lee, V. M. and Doms, R. W. (1997) Alzheimer's A beta (1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med, 3: 1021-1023.
4. Crook, R., Verkkoniemi, A., Perez-Tur, J., Metha, N., Baker, M., Houlden, H., Farrer, M., Hutton, M., Lincoln, S., Hardy, J., Gwinn, K., Somer, M., Paetau, A., Kalimo, H., Ylikoski, R., Poyhonen, M., Kucera, S. and Haltia, M. (1998) A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nat Med, 4: 452-455.
5. Geula, C., Wu, C. K., Saroff, D., Lorenzo, A., Yuan, M. and Yankner, B. A. (1998) Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med, 4: 827-831.
6. Gomez-Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E. and Hyman, B. T. (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol, 41: 17-24.
7. Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., Greengard, P. and Relkin, N. R.(2000) Intraneuronal Abeta42 accumulation in human brain. Am J Pathol, 156: 15-20.
8. Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P. and Xu, H. (1999) Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci USA, 96: 742-747.
9. Gyure, K. A., Durham, R., Stewart, W. F., Smialek, J. E. and Troncoso, J. C. (2001) Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med, 125: 489-492.
10. Katayama, T., Imaizumi, K., Sato, N., Miyoshi, K., Kudo, T., Hitomi, J., Morihara, T., Yoneda, T., Gomi, F., Mori, Y., Nakano, Y., Takeda, J., Tsuda, T., Itoyama, Y., Murayama, O., Takashima, A., St George-Hyslop, P., Takeda, M. and Tohyama, M. (1999) Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol, 1: 479-485.
11. Morishima-Kawashima, M. and Ihara, Y. (1998) The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells. Biochemistry, 37: 15247-15253.
12. Tabira, T., Chui, D. H. and Kuroda, S. (2002a) Significance of intracellular Abeta42 accumulation in Alzheimer's disease. Front Biosci, 7: a44-49.
13. Tabira, T., Chui, D. H., Nakayama, H., Kuroda, S. and Shibuya, M. (2002b) Alzheimer's disease with spastic paresis and cotton wool type plaques. J Neurosci Res, (in press).
14. Walsh, D. M., Tseng, B. P., Rydel, R. E., Podlisny, M. B. and Selkoe, D. J. (2000) The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry, 39: 10831-10839.
15. Wirths, O., Multhaup, G., Czech, C., Blanchard, V., Moussaoui, S., Tremp, G., Pradier, L., Beyreuther, K. and Bayer, T. A. (2001) Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett, 306: 116-120.
16. Zhang, Y., McLaughlin, R., Goodyer, C. and LeBlanc, A. (2002) Selective cytotoxicity of intracellular amyloid beta peptide1.42 through p53 and Bax in cultured primary human neurons. J Cell Biol, 156: 519-529.