Induction of 8-oxo-dGTPase activity in human lymphoid cells and normal fibroblasts by oxidative stress

Toxicology

Volumn 146, Issue 2-3, 2000, Pages 83-92

  Meyer, Frauke ^a   Fiala, Emerich ^b   Westendorf, Johannes ^a  

^a University of Medical School Hamburg Eppendorf   (Germany)

^b AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

8 oxo dGTPase; Gene expression; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CYCLOHEXIMIDE; DACTINOMYCIN; GUANOSINE TRIPHOSPHATASE; HYDROGEN PEROXIDE;

ARTICLE; CELL METABOLISM; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; HUMAN; HUMAN CELL; HYDROLYSIS; LYMPHOID CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA REPAIR ENZYMES; FIBROBLASTS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROGEN PEROXIDE; JURKAT CELLS; KINETICS; LYMPHOCYTES; OLIGONUCLEOTIDES; OXIDANTS; OXIDATIVE STRESS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0034607713     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00140-2     Document Type: Article

References (34)

1. Akiyama, M., Maki, H., Sekiguchi, M., 1989. A specific role of MutT protein: to prevent dG:dA mispairing in DNA replication. Proc. Natl. Acad. Sci. USA 86, 3949-3952.
2. Ames, B.N., Gold, L.S., 1991. Endogenous mutagens and the causes of aging and cancer. Mutat. Res. 250, 3-16.
3. Au, K.G., Clark, S., Miller, J.H., Modrich, P., 1989. Escherichia coli mutY gene encodes an adenine glycosylase active on G:A mispairs. Proc. Natl. Acad. Sci. USA 86, 8877-8881.
4. Bessho, T., Tano, K., Kasai, H., Ohtsuka, E., Nishimura, S., 1993. Evidence of two repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. J. Biol. Chem. 268, 19416-19421.
5. Bialkowski, K., Kasprzak, K.S., 1998. A novel assay of 8-oxo-2′-deoxyguanosine 5′-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity in cultured cells and its use for evaluation of cadmium(II) inhibition of this activity. Nucleic Acids Res. 26, 3194-3201.
6. Bradford, M., 1974. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
7. Burdon, R.H., 1995. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Rad. Biol. Med. 18, 775-794.
8. Cabrera, M., Nghiem, Y., Miller, J.H., 1988. MutM, a second mutator locus in Escherichia coli that generates G:C → T:A transversions. J. Bacteriol. 170, 5405-5407.
9. Cheng, K.C., Cahill, D.S., Kasai, H., Nishimura, S., Loeb, L.A., 1992. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions. J. Biol. Chem. 269, 15318-15324.
10. Chomczynski, P., Sacchi, N., 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
11. Chung, M.H., Kasai, H., Jones, D.S., Inoue, H., Ishikawa, E., Ohtsuka, S., Nishimura, S., 1991. An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA. Mutat. Res. 254, 1-12.
12. Demple, D., Harrison, L., 1994. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63, 915-948.
13. Furuichi, M., Yoshida, M.C., Oda, H., Tajri, T., Nakabeppu, Y., Tsuzuki, T., Sekiguchi, M., 1994. Genomic structure and chromosome location of the human mutT homologue MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. Genomics 24, 485-490.
14. Gajewski, E., Rao, G., Nackerdien, Z., Dizdarogulu, M., 1990. Modification of DNA bases in mammalian chromatin by radiation-generated free radicals. Biochemistry 29, 7876-7882.
15. Hayakawa, H., Taketomi, A., Sakumi, K., Kuwano, M., Sekiguchi, M., 1995. Generation and elimination of 8-oxo7,8-dihydro-2′-deoxyguanosine-5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. Biochemistry 34, 89-95.
16. Hollstein, M., Sidransky, D., Vogelstein, B., Harris, C.C., 1991. p53 mutations in human cancers. Science 253, 49-53.
17. Kamiya, H., Miura, K., Ishikawa, H., Inoue, H., Nishimurs, S., Ohtsuka, E., 1992. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res. 52, 3483-3485.
18. Kasai, H., Nishimura, S., 1984. Hydroxylation of deoxyguanosine at C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res. 12, 2137-2145.
19. Kasai, H., Crain, P.F., Kuchino, Y., Nishimura, S., Ootsuyama, A., Tanooka, H., 1986. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 7, 1849-1851.
20. Kennedy, C.H., Cueto, R., Belinsky, S.A., Lechner, J.F., Pryor, W.A., 1998. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. FEBS Lett. 429, 17-20.
21. Maki, H., Sekiguchi, M., 1992. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355, 273-275.
22. McGoldrick, J.P., Yeh, Y.C., Solomon, M., Essigmann, J.M., Lu, A.L., 1995. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol. Cell. Biol. 15, 989-996.
23. Michaels, M.L., Pham, L., Cruz, C., Miller, J.H., 1991. MutM, a protein that prevents G:C → T:A transversions, is formamidopyrimidine-DNA glycosylase. Nucleic Acids Res. 19, 3629-3632.
24. Michaels, M.L., Cruz, C., Grollman, A.P., Miller, J.H., 1992. Evidence that MutM and MutY combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl. Acad. Sci. USA 89, 7022-7025.
25. Mo, J.Y., Maki, H., Sekiguchi, M., 1992. Hydrolytic elimination of a mutagenic nucleotide, 8-oxo-dGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. Proc. Natl. Acad. Sci. USA 89, 11021-11025.
26. Nghiem, Y., Cabrera, M., Cupples, C.G., Miller, J.H., 1988. The mutY gene: A mutator locus in Escherichia coli that generates G:C → T:A transversions. Proc. Natl. Acad. Sci. USA 85, 2709-2713.
27. Oda, H., Nakabeppu, Y., Furuichi, M., Sekiguchi, M., 1997. Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. J. Biol. Chem. 272, 17843-17850.
28. Sakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S., Maki, H., Sekiguchi, M., 1993. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268, 23 524-23 530.
29. Sambrook, J., Fritsch, E., Maniatis, T., 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
30. Sekiguchi, M., 1996. MutT-related avoidance mechanism for DNA synthesis. Genes Cells 1, 139-145.
31. Shibutani, S., Takeshita, M., Grollman, A.P., 1991. Insertion of specific basaes during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349, 431-434.
32. Treffers, H.P., Spinelli, V., Belser, N.O., 1954. A factor (or mutagenic gene) influencing mutation rates in Escherichia coli. Proc. Natl. Acad. Sci. USA 40, 1064-1071.
33. Wani, G., D'Ambrosio, S.M., 1995. Cell type-specific expression of human 8-oxo-7,8-dihydroguanosine triphosphatase in normal human breast and skin tissues in vivo. Carcinogenesis 16, 277-283.
34. Wani, G., Milo, G.E., D'Ambrosio, S.M., 1998. Enhanced expression of the 8-oxo-7,8-dihydro-deoxyguanosine triphosphatase gene in human breast tumor cells. Cancer Lett. 125, 123-140.