Learning deficits and dysfunctional synaptic plasticity induced by aggregated amyloid deposits in the dentate gyrus are rescued by chronic treatment with indomethacin

European Journal of Neuroscience

Volumn 17, Issue 9, 2003, Pages 1921-1927

  Stéphan, Aline ^a   Laroche, Serge ^a   Davis, Sabrina ^a  

^a CNRS   (France)

Author keywords

Alzheimer's disease; Inflammation; LTP; NSAID; Rat; Spatial learning

Indexed keywords

AMYLOID BETA PROTEIN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SENILE PLAQUE; SYNAPSE; TREATMENT OUTCOME; WORKING MEMORY;

AMYLOID BETA-PROTEIN; ANIMALS; CELL AGGREGATION; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIALS; INDOMETHACIN; MALE; MEMORY DISORDERS; NEURONAL PLASTICITY; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037716471     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02610.x     Document Type: Article

References (35)

1. Benveniste, E.N., Nguyen, V.T. & O'Keefe, G.M. (2001) Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem. Int., 39, 381-391.
2. Blasko, I., Marx, F., Steiner, E., Hartmann, T. & Grubeck-Loebenstein, B. (1999) TNFα plus IFNγ induce the production of Alzheimer-amyloid peptides and decreases the secretion of APPs. FASEB J., 12, 63-68.
3. Breitner, J.C.S., Welsh, K.A., Helms, M.J., Gaskell, P.C., Gau, B.A., Roses, A.D., Pericak-Vance, M.A. & Saunders, A.M. (1995) Delayed onset of Alzheimer's disease with non steriodal anti inflammatory and histamine H2 blocking drags. Neurobiol. Aging, 16, 523-530.
4. Buxbaum, J.D., Oishi, M., Chen, H.I., Pinka. S., Kramarski, R., Jaffe, E.A., Gandy, S.E. & Greengard, P. (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of Alzheimer β/A4 amyloid protein precursor. Proc. Natl Acad. Sci. USA, 89, 10075-10078.
5. Cotman, C.W., Tenner, A.J. & Cummings, B.J. (1996) beta-Amyloid converts an acute phase injury response to chronic injury responses. Neurobiol. Aging, 17, 723-731.
6. Davis, S., Salin, H., Helme-Guizon, A., Dumas, S., Stéphan, A., Corbex, M., Mallet, J. & Laroche, S. (2000) Dysfunctional regulation of αCaMKII and syntaxin 1B transcription after induction of LTP in the aged rat. Eur. J. Neurosci., 12, 3276-3282.
7. Gahtan, R. & Overmier, J.B. (1999) Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli. Neurosci. Biobehav. Rev., 23, 615-633.
8. Giulian, D. (1999) Microglia and the immune pathology of Alzheimer disease. Am. J. Hum. Genet., 65, 13-18.
9. Griffin, W.S., Sheng, J.G., Roberts, G.W. & Mrak, R.E. (1995) Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol., 54, 276-281.
10. Griffin, W.S., Sheng, J.G., Royston, M.C., Gentleman, S.M., McKenzie, J.E., Graham, D.I., Roberts, G.W. & Mrak, R.E. (1998) Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression. Brain Pathol., 8, 65-72.
11. Hauss-Wegrzyniak, B., Dobrzanski, P., Stoehr, J.D. & Wenk, G.L. (1998) Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res., 780, 294-303.
12. Hauss-Wegrzyniak, B., Lynch, M.A., Vraniak, P.D. & Wenk, G.L. (2002) Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses. Exp. Neurol., 176, 336-341.
13. Hauss-Wegrzyniak, B., Vannucchi, M.G. & Wenk, G.L. (2000) Behavioural and ultrastructural changes induced by cholinergic neuroinflammation in young rats. Brain Res., 859, 157-166.
14. Heyser, C.J., Masliah, E., Samimi, A., Campbell, I.L. & Gold, L.H. (1997) Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc. Natl Acad. Sci. USA, 94, 1500-1505.
15. Hirose, Y., Imai, Y., Nakajima, K., Takemoto, N., Toya, S. & Kohsaka, S. (1994) Glial conditioned medium alters the expression of amyloid precursor protein in SH-SY5Y neuroblastoma cells. Biochem. Biophys. Res. Comm., 28, 504-509.
16. Jantzen, P.T., Conner, K.E., DiCarlo, G., Wenk, G.L., Wallace, J.L., Rojani, A.M., Coppola, D., Morgan, D. & Gordon, M.N. (2002) Microglial activation and β-amyloid deposit reduction caused by a nitric oxide-releasing non-steroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J. Neurosci., 22, 2246-2254.
17. Lim, G.P., Yang, F., Chu, T., Chen, P.; Beech, W., Teter, B., Tran, T., Ubeda, O., Hsiao Ashe, K., Frautschy, S.A. & Cole, G.M. (2000) Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J. Neurosci., 20, 5709-5714.
18. Lim, G.P., Yang, F., Chu, T., Gahtan, E., Ubesa, O., Beech, W., Overmier, J.B., Hsiao-Ashe, K., Frautschy, S.A. & Cole, G.M. (2001) Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol. Aging, 22, 983-991.
19. Mackenzie, I.R. & Munoz, D.G. (1998) Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology, 50, 986-990.
20. McGeer, P.L. & McGeer, E.G. (1998) Complement proteins and complement inhibitors in Alzheimer's disease. Res. Immunol., 143, 621-624.
21. McGeer, P.L. & McGeer, E.G. (2001) Inflammation, autotoxicity and Alzheimer disease. Neurobiol. Aging, 22, 799-809.
22. Meda, L., Cassatella, M.A., Szendrei, G.I., Otvos, L., Jr, Baron, P., Villalba, M., Ferrari, D. & Rossi, F. (1995) Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature, 374, 647-650.
23. Murray, C.A. & Lynch, M.A. (1998) Evidence that increased hippocampal expression of the cytokine interleuking-1 beta is a common trigger for ageand stress-induced impairments in long-term potentiation. J. Neurosci., 18, 2974-2981.
24. Netland, E.E., Newton, J.L., Majocha, R.E. & Tare, B.A. (1998) Indomethacin reverses the microglial response to amyloid beta-protein. Neurobiol. Aging, 19, 201-204.
25. Pachter, J.S. (1997) Inflammatory mechanisms in Alzheimer's disease: the role of beta-amyloid/glial interactions. Mol. Psychiatry, 2, 91-95.
26. Paris, D., Town, T., Mori, T., Parker, T.A., Humphrey, J. & Mullah, M. (2000) Soluble-amyloid peptides mediate vasoactivity via activation of a proinflammatory pathway. Neurobiol. Aging, 21, 183-197.
27. Rich, J.B., Rassmussen, D.X., Folstein, M.F., Carson, K.A., Kawas, C. & Brandt, J. (1995) Non steroidal anti inflammatory drugs and Alzheimer's disease. Neurology, 45, 51-55.
28. Richardson, R.L., Kim, E.-M., Shephard, R.A., Gardiner, T., Cleary, J. & O'Hare, E., (2002) Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Aβ (1-42) injections in the rat. Brain Res., 954, 1-10.
29. Rogers, J., Webster, S., Lih-Fen, L., Brachova, L., Civin, W.H., Emmerling, M., Brenda, S., Walker, D. & McGeer, P. (1996) Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging, 17, 681-686.
30. Sheng, J.G., Ito, K., Skinner, R.D., Mrak, R.E., Rovnaghi, C.R., Van Eldik, L.J. & Griffin, W.S. (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol. Aging, 17, 761-766.
31. Steele, R.J. & Morris, R.G. (1999) Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5. Hippocampus, 9, 118-936.
32. Stéphan, A., Laroche, S. & Davis, S. (2001) Generation of aggregated β-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits. J. Neurosci., 21, 5703-5714.
33. Stewart, W.F., Kawas, C., Corrada, M. & Metter, E.J. (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurology, 48, 626-632.
34. Vane, J.R. & Blotting, R.M. (1998) Anti-inflammatory drugs and their mechanisms of action. Inflamm. Res., 47, S78-S87.
35. Vereker, E., Campbell, V., Roche, E., McEntee, E. & Lynch, M.A. (2000) Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1. J. Biol. Chem., 275, 26252-26258.