Complement proteins and complement inhibitors in Alzheimer's disease

Research in Immunology

Volumn 143, Issue 6, 1992, Pages 621-624

  McGeer, P L ^a   McGeer, E G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT INHIBITOR; ENDOGENOUS COMPOUND;

AGED; ALZHEIMER DISEASE; COMPLEMENT ACTIVATION; CONFERENCE PAPER; HUMAN; HUMAN TISSUE; NERVE CELL; PRIORITY JOURNAL;

ALZHEIMER DISEASE; BRAIN; COMPLEMENT; COMPLEMENT ACTIVATION; COMPLEMENT INACTIVATORS; HUMAN;

EID: 0026757992     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2494(92)80045-M     Document Type: Conference Paper

References (30)

1. Brain microglia constitutively express b2 integrins
2. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue
3. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150-95 glycoproteins
4. Structural analysis of clusterin and its subunits in ram rete testis fluid
5. Changes in gene expression shared by scrapie and Alzheimer disease
6. Immunoglobulins and complement factors in senile plaques
7. Complement activation in amyloid plaques in Alzheimer's dementia
8. Localization of S protein and its relationship to the membrane attack complexof complement in renal tissue
9. Autoantibodies to neurofibrillary tangles and brain tissue in Alzheimer's disease
10. Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques
11. Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques
12. Presence of immunoglobulins and complements in the amyloid plaques in the brain of patients with Alzheimer's disease
13. Alzheimer's and normal brain contain mRNA for complement components C1qB, C3 and C4
14. Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
15. Immune system response in Alzheimer's disease
16. Activation of the classical complement pathway in brain tissue of Alzheimer patients
17. Detection of the membrane inhibitor of reactive lysis (CD59) in disease neurons of Alzheimer brain
18. Distribution of clusterin in Alzheimer brain tissue
19. Antibodies in the cerebrospinal fluid of some Alzheimer's disease patients recognize amoeboid microglial cells in the developing rat central nervous system
20. Complement membrane attack on nucleated cells : resistance, recovery and non-lethal effects
21. SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis
22. Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3
23. Immunological markers and neuropathological lesions in Alzheimer's disease
24. C1q binding to β-amyloid and amyloid precursor protein (APP)
25. Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria
26. Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family
27. Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease
28. Detection of brain autoantibodies in the serum of patients with Alzheimer's disease but not Down's syndrome
29. Detection of complement mRNAs in human brain by Northern hybridization analysis and polymerase chain reaction