The effects of doxorubicin on apoptosis and adhesion molecules of normal peripheral blood leukocytes - An ex vivo study

Anti-Cancer Drugs

Volumn 14, Issue 5, 2003, Pages 383-389

  Ciobotaro, Pnina ^a   Drucker, Liat ^a   Neumann, Avivit ^a   Shapiro, Hava ^a   Shapira, Jermey ^a,b   Radnay, Judith ^a   Lishner, Michael ^a,b  

^a MEIR MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Apoptosis; Doxorubicin; Integrin; Peripheral blood leukocyte; Tetraspanin

Indexed keywords

CELL ADHESION MOLECULE; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; LIPOCORTIN 5; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD11A; MONOCLONAL ANTIBODY CD18; MONOCLONAL ANTIBODY CD49D; MONOCLONAL ANTIBODY CD63; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CELL SUBPOPULATION; CLINICAL ARTICLE; CLINICAL OBSERVATION; CORRELATION ANALYSIS; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; INCUBATION TIME; LEUKOCYTE; LEUKOPENIA; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROOM TEMPERATURE; STATISTICAL SIGNIFICANCE; STEM CELL; TREATMENT OUTCOME;

ADULT; AGED; ANNEXIN A5; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL MEMBRANE; DOXORUBICIN; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; LEUKOCYTES; MIDDLE AGED; NEUTROPHILS; TREATMENT OUTCOME;

EID: 0037503648     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200306000-00010     Document Type: Article

References (29)

1. Hannun AY. Apoptosis and the dilemma of cancer chemotherapy. Blood 1997; 89:1845-1853.
2. Kamesaki H. Mechanisms involved in chemotherapy-induced apoptosis and their implications in cancer chemotherapy. Int J Hematol 1998; 68:29-43.
3. Schmitt AC, Lowe WS. Apoptosis and therapy. J Pathol 1999; 187:127-137.
4. Kaufmann HS, Earnshaw CW. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 2000; 256:42-49.
5. Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 1992; 11:121-139.
6. Wu XX, Mizutani Y, Kakehi-Y, Yoshida O, Ogawa O. Enhancement of Fas-mediated apoptosis in renal cell carcinoma by adriamycin. Cancer Res 2000; 60:2912-2918.
7. Leujene M, Ferster A, Cantinieaux B, Sariban E. Prolonged but reversible neutrophil dysfunctions differentially sensitive to granulocyte colony-stimulating factor in children with acute lymphoblastic leukemia. Br J Haematol 1998; 102:1284-1291.
8. 1 and cycling peripheral blood lymphocytes and induce massive deletion of mature T and B cells. Cancer Res 2000; 60:1901-1907.
9. Provinciali M, Ciavattini A, Di Stefano G, Argentani K, Garrazetti GG. In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients. Life Sci 1999; 64:1525-1532.
10. Kim KS, Demetri GD. Chemotherapy and neutropenia. Hematol Oncol Clin N Am 1996; 10:377-395.
11. Chucklovin A. Enhanced ex vivo apoptosis of peripheral granulocytes is a sufficient factor of neutropenia following myeloablative chemotherapy. Leuk Res 2000; 24:507-509.
12. Dedhar S. Integrin mediated signal transduction in oncogenesis: an overview. Cancer Metastasis Rev 1995; 14:165-172.
13. 2 integrins (CD11/CD18) promote apoptosis of human neutrophils. FASEB J 1997; 11:1177-1186.
14. Ropke C, Gladstone P, Nielsen M, Ledbetter JA, Svejgaard A, Odum N. Apoptosis following interleukin-2 withdrawal from T cells: evidence for a regulatory role of CD18 (beta 2-integrin) molecules. Tissue Antigens 1996; 48:127-135.
15. Baldini LG, Cro LM. Structure and function of VLA integrins: differential expression in B-cell leukemia/lymphoma. Leuk Lymph 1994; 12:197-203.
16. Toledano BJ, Bastien Y, Noya F, Mazer B. Characterization of B lymphocytes rescued from apoptosis by platelet-activating factor. Cell Immunol 1999; 191:60-68.
17. Hart SP, Ross JA, Haeslett C, Dransfield I. Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. Cell Death Differ 2000; 7:493-503.
18. Beinert T, Munzing Silvia, Possinger K, Krombach F. Increased expression of the tetraspanins CD53 and CD63 on apoptotic human neutrophils. J Leukoc Biol 2000; 67:369-373.
19. Damiano JS, Cress AE, Hazlehurst LA, Shtil AA, Dalton WS. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999; 93:1658-1667.
20. Nista A, Leonetti C, Bernardini G, Mattioni M, Santoni A. Functional role of alpha4beta1 and alpha5beta1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells. Int J Cancer 1997; 72:133-141.
21. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scan J Clin Lab Invest 1963; 21:77-89.
22. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, et al. Features of apoptotic cells measured by flow cytometry. Cytometry 1992; 13:795-808.
23. Wang X, Clowes C, Duarte R, Pu QQ. Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous stem cell transplantation. Int J Oncol 2000; 17:597-602.
24. Weimann P, Scharffetter-kochanek K, Forlow SB, Peters T, Walzog B. A role for apoptosis in the control of neutrophil homeostasis in the circulation: insight from CD18-deficient mice. Blood 2003; 101:739-746.
25. Schettini J, Salamone G, Trevani A, Gamberale R, Vermeulen M, Giordano M, et al. Stimulation of neutrophil apoptosis by immobilized IgA. J Leukoc Biol 2002; 72:685-691.
26. Kalyanaraman B, Joseph J, Kalivendi S, Wang S, Konorev E, Kotamraju S. Doxorubicin-induced apoptosis: implications in cardiotoxicity. Mol Cell Biochem 2002; 234/235:119-124.
27. Sato Y, Walley Kr, Klut ME, English D, D'yachkova Y, Hogg JC, et al. Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression. Am J Respir Crit Care Med 1999; 159:1469-1476.
28. Engervall P, Laundahl J, Alterations in adhesion molecule (CD11b/CD18 and CD62L) expression on granulocytes after chemotherapy. Eur J Clin Invest 1998; 28:924-929.
29. Ezioni A. Integrins:the glue of life. Lancet 1999; 353:341.