β2 integrins (CD11/CD18) promote apoptosis of human neutrophils

FASEB Journal

Volumn 11, Issue 13, 1997, Pages 1177-1186

  Walzog, Barbara ^a   Jeblonski, Frank ^a   Zakrzewicz, Andreas ^a   Gaehtgens, Peter ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cell morphology; DNA fragmentation assay; Inflammation; Migration; PMN; Signal transduction

Indexed keywords

CD11 ANTIGEN; CD16 ANTIGEN; CD18 ANTIGEN; DNA; INTEGRIN; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; CD11B ANTIGEN; CROSS LINKING REAGENT; DNA FRAGMENT; FC RECEPTOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERCELLULAR ADHESION MOLECULE 1; LEUKOCYTE ANTIGEN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; CELL MIGRATION; CONTROLLED STUDY; DNA CONTENT; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOSYNTHESIS; BLOOD; CELL LINE; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; IN VITRO STUDY; KINETICS; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY; TIME; VASCULAR ENDOTHELIUM;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD18; APOPTOSIS; CELL LINE; CHEMOTAXIS, LEUKOCYTE; CROSS-LINKING REAGENTS; DNA; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; KINETICS; MACROPHAGE-1 ANTIGEN; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; RECEPTORS, IGG; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031280365     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.13.9367353     Document Type: Article

References (42)

1. Kerr, J. F. R., Wyllie, A. H., and Currie, A. R. (1972) Apoptosis: a basic phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257
2. Wyllie, A. H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (London) 284, 555-556
3. Squier, M. K. T., Sehnert, A. J., and Cohen, J. J. (1995) Apoptosis in leukocytes. J. Leukoc. Biol. 57, 2-10
4. Whyte, M. K. B., Meagher, L. C., MacDermot, J., and Haslett, C. (1993) Impairment of function in aging neutrophils is associated with apoptosis. J Immunol. 150, 5124-5134
5. Dransfield, I., Buckle, A.-M., Savill, J. S., Mcdowall, A., Haslett, C., and Hogg, N. (1994) Neutrophil apoptosis is associated with a reduction in CD16 (FcgammaRIII) expression. J. Immunol. 153, 1254-1263
6. Savill, J., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., and Haslett, C. (1989) Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83, 865-875
7. Hall, S. E., Savill, J. S., Henson, P. M., and Haslett, C. (1994) Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specinc lectin. J. Immunol. 153, 3218-3227
8. Payne, C. M., Glasser, L., Tischler, M. E., Wyckoff, D., Cromey, D., Fiederlein, R., and Bohnert, O. (1994) Programmed cell death of the normal human neutrophil: An in vitro model of senescence. Microsc. Res. Tech. 28, 327-344
9. Cox, G., Gauldie, J., and Jordana, M. (1992) Bronchial epithelial cell-derived cytokines (G-CSF and GM-CSF) promote the survival of peripheral blood neutrophils in vitro. Am. J. Respir. Cell Mol. Biol. 7, 507-513
10. Ohata, H., Yatomi, Y., Sweeney, E. A., Hakomori, S., and Igarashi, Y. (1994) A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils. FEBS Lett. 355/267-270
11. Smith, C. A., Farrah, T., and Goodwill, R. G. (1994) The TNF receptor superfamily of cellular and viral proteins: activation, costimulation and death. Cell 76, 959-962
12. Liu, Z. G., Hsu, H. L., Goeddel, D. V., and Karin, M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87, 565-576
13. Pushkareva, M., Obeid, L. M., and Hannun, Y. A. (1995) Ceramide: an endogeneous regulator of apoptosis and growth suppression. Immunol. Today 160, 294-297
14. Arnaout, M. A. (1990) Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 75, 1037-1050
15. Nathan, C., Srimal, S., Farber, C., Sanchez, E., Kabbash, L., Asch, A., Gailit, J., and Wright, S. D. (1989) Cytokine-induced respiratory burst of human neutrophils: Dependence on extracellular matrix proteins and CD11/CD18 integrins. J. Cell Biol. 109, 1341-1349
16. 2 Integrin-dependent ryrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor. J. Cell Biol. 127, 1477-1483
17. 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils. J. Cell Biol. 126, 1111-1121
18. 21ras through tyrosine phosphorylation of the protooncogene Vav. Proc. Natl. Acad. Sci. USA 93, 8431-8436
19. syk and Src family kinases in neutrophils spreading over fibrinogen. J. Immunol. 158, 1902-1910
20. 2 integrins mediate protein tyrosine phosphorylation in human neutrophils. J. Leukoc. Biol. 59, 747-753
21. 2+, exocytosis of azurophilic granules, quantitative tip-regulation of CD18, shedding of L-selectin, and actin polymerization. J. Leukoc. Biol. 56, 625-635
22. Ley, K. (1996) Molecular mechanisms of leukocyte recruitment in the inflammatory process. Cardiovasc. Res. 32, 733-742
23. Baggiolini, M., Boulay, F., Badwey, J. A., and Curnutte, J. T. (1993) Activation of neutrophil leukocytes: Chemoattractant receptors and respiratory burst. FASEB J. 7, 1004-1010
24. Savill, J., Fadok, V., Henson, P., and Haslett, C. (1993) Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 14, 131-136
25. Hjorth, R., Jonsson, A. K., and Vretblad, P. (1981) A rapid method for purification of human granulocytes using Percoll. A comparison with dextran sulfate. J. Immunol. Methods 43, 95-101
26. Babior, B. M., Kipnes, R. S., and Curnutte, J. T. (1973) Biological defense mechanisms: The production by leukocytes of superoxide, a potential bactericidal agent. J. Clin. Invest. 52, 741-744
27. Takahashi, K., Sawasaki, Y., Hata, J.-I., Mukai, K., and Goto, T. (1990) Spontaneous transformation and immortalization of human endothelial cells. In Vitro Cell Dev. Biol 25, 265-274
28. Wright, S. D., Rao, P. E., Van Voorhis, W. C., Craigmyle, L. S., Iida, K., Talle, M. A., Westberg, E. F., Goldstein, G. W., and Silverstein, S. C. (1983) Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc. Natl. Acad. Sci. USA 80, 5699-5703
29. Thomas, M. L. (1989) The leukocyte common antigen family. Annu. Rev. Immunol 7, 339-369
30. Miyamoto, S., Akiyama, S. K., and Yamada, K. M. (1995) Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885
31. van de Winkel, J. G. J., and Capel, P. J. A. (1993) Human IgG Fc receptor hetrogeneity: molecular aspects and clinical implications. Immunol. Today 14, 215-221
32. Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaoul, M. A., and Mayadas, T. N. (1996) A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation. Immunity 5, 653-666
33. Yousefi, S., Green, D. R., Blaser, K., and Simon, H.-U. (1994) Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 91, 10868-10872
34. Dusi, S., Della Bianca, V., Donini, M., Nadalini, K. A., and Rossi, F. (1996) Mechanisms of stimulation of the respiratory burst by TNF in nonadherent neutrophils - Its independence of lipidic transmembrane signaling and dependence on protein tyrosine phosphorylation and cytoskeleton. J. Immunol. 157, 4615-4623
35. lyn in adherent human neutrophils: Evidence for a role of divalent cations in regulating neutrophil adhesion and protein tyrosine kinase activities. Circ. Shock 15, 297-311
36. c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133, 895-910
37. 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils. J. Cell Biol. 127, 1139-1147
38. Beyaert, R., and Fears, W. (1994) Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. FEBS Lett. 340, 9-16
39. Liles, W. C., Ledbetter, J. A., Waltersdorph, A. W., and Klebanoff, S. J. (1995) Cross-linking of CD18 primes human neutrophils for activation of the respiratory burst in response to specific stimuli: Implications for adhesion-dependent physiological responses in neutrophils. J. Leukoc. Biol 58, 690-697
40. Watson, R. W. G., Rotstein, O. D., Nathens, A. B., Parodo, J., and Marshall, J. C. (1997) Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement. J. Immunol. 158, 945-953
41. Chitinis, D., Dickerson, C., Munster, A. M., and Winchurch, R. A. (1996) Inhibition of apoptosis in polymorphonuclear neutrophils from burn patients. J. Leukoc. Biol. 59, 835-839
42. Tsuchida, H., Takeda, Y., Takei, H., Shinzawa, H., Takahashi, T., and Sendo, F. (1995) In vivo regulation of rat neutrophil apoptosis occuring spontaneously or induced with TNF-α or cycloheximide. J. Immunol. 154, 2403-2412