Functional role of α4β1 and α5β1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells

International Journal of Cancer

Volumn 72, Issue 1, 1997, Pages 133-141

  Nista, Anna ^a   Leonetti, Carlo ^a   Bernardini, Giovanni ^a   Mattioni, Manlio ^a   Santoni, Angela ^a,b  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ARGINYLGLYCYLASPARTIC ACID; DOXORUBICIN; FIBRONECTIN; FIBRONECTIN RECEPTOR; GLYCOPROTEIN; INTEGRIN; MONOCLONAL ANTIBODY; RNA; VASCULAR CELL ADHESION MOLECULE 1; BETA1 INTEGRIN;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CELL ADHESION; CELL CYCLE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; CYTOFLUOROMETRY; DIAGNOSIS; DRUG RESISTANCE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BREAST TUMOR; CELL CULTURE; CELL DIVISION; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ANTIGENS, CD29; BREAST NEOPLASMS; CELL ADHESION; CELL DIVISION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; POLYMERASE CHAIN REACTION; RECEPTORS, FIBRONECTIN; TUMOR CELLS, CULTURED; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0030612249     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970703)72:1<133::AID-IJC19>3.0.CO;2-K     Document Type: Article

References (26)

1. AKIYAMA, S.K., OLDEN, K. and YAMADA, K.M., Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev., 14, 173-189 (1995)
2. ALBELDA, S., Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab. Invest, 68, 4-17 (1993).
3. ARGRAVES, W.S., SUZUKI, S., ARAI, H., THOMPSON, K., PIERSCHBACHER, M.D. and RUOSLAHTI, E., Amino acid sequence of the human fibronectin receptor. J. Cell Biol., 105, 1183-1190 (1987).
4. BRADLEY, G., SHARMA, R., RAJALAKSHMI, S. and LING, V., P-glycoprotein expression during tumor progression in the rat liver. Cancer Res., 52, 5154-5161 (1992).
5. CHEVILLARD, S., POUILLART, P., BELDJORD, C., ASSELAIN, B., BEUZEBOC, P., MAGDELENAT, H. and VIELH, P., Sequential assessment of multidrug resistance phenotype and measurement of S-phase fraction as predictive markers of breast cancer response to neoadjuvant chemotherapy. Cancer, 77, 292-300 (1996).
6. CIANFRIGLIA, M., YASSEN, A., TOMBESI, M., SAMOGGIA, P., BARCA, S. and CASERTA, M., Expression of lymphocyte homing receptor gene is lost in multi-drug-resistant variant of human lymphoblastoid CCRF-CEM cells. Int. J. Cancer, 49, 394-397 (1991).
7. DEL BUFALO, D., BIROCCIO, A., SODDU, S., LAUDONIO, N., D'ANGELO, C., SACCHI, A. and ZUPI, G., Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene. J. clin. Invest., 98, 1-9 (1996).
8. ELICES, M.J., OSBORN, L., TAKADA, Y., CROUSE, S., LUHOWSKYJ, S., HEMLER, M.E. and LOBB, R.R., VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 60, 577-584 (1990).
9. KOCH, A.E., HALLORAN, M.M., HASKELL, C.J., SHAH, M.R. and POLVERINI, P.J., Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature (Lond.), 376, 517-519 (1995).
10. KOUKOULIS, G.K., VIRTANEN, I., KOHRONRN, M., LAITINEN, L., QUARANTA, V. and GOULD, V.E., Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Amer. J. Pathol., 139, 787-799 (1991).
11. LOBB, R., CHI-ROSSO, G., LEONE, D., ROSA, M., NEWMAN, B., LUHOWSKYJ, S., OSBORN, L., SCHIFFER, S., BENJAMIN, C., DOUGAS, I., HESSION, C. and CHOW, P., Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1. Biochem. biophys. Res. Comm., 178, 1498-1504 (1991).
12. MERRIFIELD, R.B., Solid-phase peptide synthesis: the synthesis of a tetrapeptide. J. Amer. Chem. Soc., 85, 2149-2154 (1963).
13. MORTARINI, R., GISMONDI, A., SANTONI, A., PARMIANI, G. and ANICHINI, A., Role of the α5β1 integrin receptor in the proliferative response of quiescent human melanoma cells to fibronectin. Cancer Res., 52, 4499-4506 (1992).
14. OKAHARA, H., YAGITA, H., MIYAKE, K. and OKUMURA, K., Involvement of very late antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor α enhancement of experimental metastasis. Cancer Res., 54, 3233-3236 (1994).
15. RIVOLTINI, L., CATTORETTI, G., ARIENTI, F., MASTROIANNI, A., MELANI, C., COLOMBO, M.P. and PARMIANI, G., The high lysability by LAK cells of colon-carcinoma cells resistant to doxorubicin is associated with a high expression of ICAM-1, LFA-3, NCAM and a less-differentiated phenotype. Int. J. Cancer, 47, 746-754 (1991).
16. ROMANIC, A.M. and MADRI, J.A., The induction of 72 KD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. J. Cell Biol, 125, 1165-1178 (1994).
17. RUOSLAHTI, E. and REED, J.C., Anchorage dependence, integrins and apoptosis. Cell, 77, 477-478 (1994).
18. SHIMIZU, Y., VAN SEVENTER, G., HORGAN, K. and SHAW, S., Costimulation of proliferative responses of resting CD4 and T cells by interaction of VLA4 and VLA5 with fibronectin or VLA6 with Iaminin. J. Immunol., 145, 59-67 (1990).
19. TAKADA, Y., ELICES, M.J., CROUSE, C. and HEMLER, M.E., The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J., 8, 1361-1368 (1989).
20. TAKADA, Y, MURPHY, E., PIL, P., CHEN, C., GINSBERG, M.H. and HEMLER, M.E., Molecular cloning and expression of the cDNA for α3 subunit of human α3β1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol., 115, 257-266 (1991).
21. THOMPSON, E.W., PAIK, S., BRUNNER, N., SOMMERS, C.L., ZUGMAIER, G., CLARKE, R., SHIMA, T.B., TORRI, J., DONAHUE, S., LIPPMAN, M.E., MARTIN, G.R. and DICKSON, R.B., Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. cell. Phys., 150, 534-544 (1992).
22. VARNER, J.A., EMERSON, D.A. and JULIANO, R.L., Integrin α5β1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol. Biol. Cell, 6, 725-740 (1995).
23. WARY, K.K., MAINIERO, F., ISAKOFF, S.J., MARCANTONIO, E.E. and GIANCOTTI, F., The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell, 87, 733-743 (1996).
24. WEINSTEIN, R.S., JAKATE, S.M., DOMINGUEZ, J.M., LEBOVITZ, M.D., KOUKOULIS, G.K., KUSZAK, J.R., KLUSENS, L.F., GROGAN, T.M., SACLARIDES, T.J., RONINSON, I.B. and COON, J.S., Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis. Cancer Res., 51, 2720-2726 (1991).
25. ZHANG, Z., VUORI, K., REED, J.C. and RUOSLAHTI, E., The α5β1 integrin support survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc. nat. Acad. Sci. (Wash.), 92, 6161-6165 (1995).
26. ZHU, X., OHTSUBO, M., BOHMER, R., ROBERTS, J.M. and ASSOIAN, R.K., Adhesion dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol., 133, 391-403 (1996).