Enhanced ex vivo apoptosis of peripheral granulocytes is a sufficient factor of neutropenia following myeloablative chemotherapy

Leukemia Research

Volumn 24, Issue 6, 2000, Pages 507-509

  Chukhlovin, Alexei ^a  

^a Center of Haematology   (Russian Federation)

Author keywords

Antineoplastic drugs; Apoptosis; Blood; Granulocytes; Haemopoietic stem cell transplantation

Indexed keywords

ACRIDINE ORANGE; BUSULFAN; CYCLOPHOSPHAMIDE; MELPHALAN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ACUTE LEUKEMIA; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GRANULOCYTE; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUTROPENIA; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL;

ADOLESCENT; ADULT; APOPTOSIS; BREAST NEOPLASMS; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HODGKIN DISEASE; HUMANS; LEUKEMIA; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; MULTIPLE MYELOMA; MYELOABLATIVE AGONISTS; NEUTROPENIA; TIME FACTORS; TRANSPLANTATION CONDITIONING;

EID: 0033998656     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(99)00199-X     Document Type: Article

References (8)

1. Savill J.S., Wyllie A.H., Henson J.E., Walport M.J., Henson P.M., Haslett C. Macrophage phagocytosis of aging neutrophils in inflammation: programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83:1989;865.
2. Bogdanov K.V., Chukhlovin A.B., Zaritskey A.Y.u, Frolova O.I., Afanasiev B.V. Ultraviolet irradiation induces double-strand breaks and apoptosis in normal granulocytes and chronic myeloid leukaemia blasts. Br. J. Haematol. 98:1997;869.
3. Zherbin E.A., Chukhlovin A.B. Possible association of membrane and nuclear changes in gamma-irradiated rat thymocytes. Int. J. Radiat. Biol. 45:1984;179.
4. Andonequi G., Trevani A.S., Lopez D.H. Inhibition of human neutrophil apoptosis by platelets. J. Immunol. 158:1998;3372.
5. Hebert H.-J., Takano T., Holthoefer H., Brady H.R. Sequential morphologic events during apoptosis of human neutrophils. Modification by lipoxygenase-derived eicosanoids. J. Immunol. 157:1996;3105.
6. Greenberg P.L. Apoptosis and its role in the myelodysplastic syndromes: implications for disease natural history and treatment. Leuk. Res. 22:1998;1123.
7. Newburger P.E., Parmley R.T. Neutrophil structure and function. Hoffman R., Benz E.J., Shattil S.J., Furie B., Cohen H.J. Hematology. Basic Principles and Practice. 1991;522 Churchill Livingstone, New York.
8. Spiekerman K., Rasler J., Emmendoerfer A., Elsner J., Welte K. Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications. Leukemia. 11:1997;466.