Activation of protein C during reperfusion in clinical liver transplantation

Transplantation

Volumn 75, Issue 4, 2003, Pages 467-472

  Ilmakunnas, Minna ^a,b   Petäjä, Jari ^a   Höckerstedt, Krister ^a   Mäkisalo, Heikki ^a   Fernandez, Jose A ^c   Griffin, John H ^c   Jansson, Sten Erik ^a   Repo, Heikki ^a,b   Pesonen, Eero J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CD11B ANTIGEN; L SELECTIN; PROTEIN C;

ADULT; AGED; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; LEUKOCYTE ACTIVATION; LEUKOCYTE DIFFERENTIAL COUNT; LIVER FAILURE; LIVER PERFUSION; LIVER TRANSPLANTATION; MALE; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY;

ADULT; AGED; ANTIGENS, CD11B; FEMALE; HEPATIC ARTERY; HUMANS; L-SELECTIN; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MONOCYTES; NEUTROPHILS; PHAGOCYTES; POSTOPERATIVE COMPLICATIONS; PROTEIN C; REPERFUSION INJURY; THROMBOSIS;

EID: 0037468453     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000046529.83650.8A     Document Type: Article

References (30)

1. Harper PL, Luddington RJ, Carrell RW, et al. Protein C deficiency and portal thrombosis in liver transplantation in children. Lancet 1988; II: 924-927.
2. Suehiro T, Boros P, Sheiner P, et al. Effluent levels of thrombomodulin predict early graft function in clinical liver transplantation. Liver 1997; 17: 224-229.
3. Diacovo TG, Roth SJ, Buccola JM, et al. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood 1996; 88: 146-157.
4. Grey ST, Tsuchida A, Hau H, et al. Selective inhibitory effect of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ, or phorbol ester. J Immunol 1994; 153: 3664-3672.
5. White B, Schmidt M, Murphy C, et al. Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor κB (NF-κB) and tumour necrosis factor α (TNF-α) production in the THP-1 monocytic cell line. Br J Haematol 2000; 110: 130-134.
6. Joyce DE, Gelbert L, Ciaccia A, et al. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 1119-1203.
7. Esmon CT, Taylor FB, Snow TR. Inflammation and coagulation. Linked processes potentially regulated through a common pathway mediated by protein C. Thromb Haemostasis 1991; 66: 160-165.
8. Taylor FB, Chang A, Esmon CT, et al. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987; 79: 918-925.
9. Roback MG, Stack AM, Thompson C, et al. Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits. Shock 1998; 9: 138-142.
10. Bernard GR, Vincent J, Laterre P, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
11. Petäjä J, Pesonen EJ, Fernandez AJ, et al. Activated protein C and inflammation in human myocardium after heart surgery. Am J Hematol 2001; 67: 210-212.
12. Petäjä J, Pesonen EJ, Fernandez JA, et al. Cardiopulmonary bypass and activation of antithrombotic plasma protein C. J Thorac Cardiovasc Surg 1999; 118: 422-429.
13. Gruber A, Griffin JH. Direct detection of activated protein C in blood from human subjects. Blood 1992; 79: 2340-2348.
14. Kishimoto TK, Jutila MA, Berg EL, et al. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 1989; 245: 1238-1241.
15. Calafat J, Kuijpers TW, Janssen H, et al. Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18. Blood 1993; 81: 3122-3129.
16. Repo H, Jansson S-E, Leirisalo-Repo M. Flow cytometric determination of CD11b upregulation in vivo. J Immunol Methods 1993; 164: 193-202.
17. Repo H, Jansson S-E, Leirisalo-Repo M. Anticoagulant selection influences flow cytometric determination of CD11b upregulation in vivo and ex vivo. J Immunol Methods 1995; 185: 65-79.
18. Gu J, Katsuura Y, Ferrell G, et al. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 2000; 95: 1687-1693.
19. Taylor FB Jr., Peer GT, Lockhart MS, et al. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 2001; 97: 1685-1688.
20. Shibata M, Kumar SR, Amar A, et al. Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 2001; 103: 1799-1805.
21. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, et al. The endothelial cell protein C receptor augments protein C activation by thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A 1996; 93: 10212-10216.
22. Esmon CT, Xu J, Gu J, et al. Endothelial protein C receptor. Thromb Haemostas 1999; 82: 251-258.
23. Macko RF, Killewich LA, Fernandez JA, et al. Brain-specific protein C activation during carotid artery occlusion in humans. Stroke 1999; 30: 542-545.
24. Taylor FB, Stearns-Kurosawa DJ, Kurosawa S, et al. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 2000; 95: 1680-1686.
25. Riewald M, Petrovan RJ, Donner A, et al. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-1882.
26. Yamaguchi Y, Hisama N, Okajima K, et al. Pretreatment with activated protein C or active human urinary thrombomodulin attenuates the production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion injury in rat liver. Hepatology 1997; 25: 1136-1140.
27. Hirose K, Okajima K, Taoka Y, et al. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg 2000; 232(2): 272-280.
28. Mizutani A, Okajima K, Uchiba M, et al. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 2000; 95(12): 3781-3787.
29. Jaeschke H, Farhood A, Bautista AP, et al. Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am J Physiol 1993; 264: G801-809.
30. Petäjä J, Hakala L, Rasi V, Griffin JH. Circulating activated protein C in subjects with heterozygous Gln506-factor V. Haemostasis 1998; 28: 31-36.