Effector CD8+CD45RO-CD27-T cells have signalling defects in patients with squamous cell carcinoma of the head and neck

British Journal of Cancer

Volumn 88, Issue 2, 2003, Pages 223-230

  Kuss, I ^a   Donnenberg, A D ^a,b   Gooding, W ^a   Whiteside, T L ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

chain; Apoptosis; Cancen; Memory T cells; Na ve T cells

Indexed keywords

CD27 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; IONOMYCIN; PADGEM PROTEIN; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HEAD AND NECK CANCER; HUMAN; MALE; MEMORY CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE; VENOUS BLOOD;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANNEXIN A5; ANTIGENS, CD27; ANTIGENS, CD45; APOPTOSIS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; IONOMYCIN; IONOPHORES; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TETRADECANOYLPHORBOL ACETATE;

EID: 0037468122     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600694     Document Type: Article

References (33)

1. - human T cells. J Immunol, 165: 1910-1917
2. + peripheral T lymphocytes in patients with melanoma. Clin Cancer Res 7: 947-957
3. Gastman BR, Johnson DE, Whiteside TL, Rabinowich H (1999) Caspase-mediated degradation of TCR-ζ chain. Cancer Res 59: 1422-1427
4. Hamann D, Baars PA, Rep M, Hooibrink B, Kerkhof-Garde S, Klein M, van Lier R (1997) Phenotypic and functional separation of memory and effector himan CD8 T cells. J Exp Med 186: 1407-1418
5. Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos D, Wieder E, Schmidt D, Hoh R, Neese R, Macallan D, Deeks S, McCune JM (1999) Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature Medicine 5: 83-88
6. Hendrics J, Gravestein LA, Tesselaar K, van Lier RAW, Schumacher TNM, Borst J (2000) CD27 is required for generation and long-term maintenance of T-cell immunity. Nature Immunol 1: 433-439
7. Hoffmann T, Dworacki G, Tsukishiro T, Meidenbauer N, Gooding W, Johnson JT, Whiteside TL (2002) Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clin Cancer Res. 8: 2553-2562
8. Kiessling R, Wasserman K, Horiguchi S, Kono K, Sjoberg J, Pisa P, Petersson M (1999) Tumour-induced immune dysfunction. Cancer Immunol Immunother 48:(7) 353-362
9. Kono K, Salazar-Onfray F, Petersson M, Hansson J, Masucci G, Wasserman K, Nakazawa T, Anderson P, Kiessling R (1996) Hydrogen peroxide secreted by tumour-derived macrophages down-modulates signal-transducing ζ molecules and inhibits tumour-specific T cell- and natural killer cell-mediated cytotoxicity. Eur J Immunol 26: 1308-1313
10. Kuss I, Saito T, Johnson JT, Whiteside TL (1999) Clinical significance of decreased ζ chain expression in peripheral blood lymphocytes of patients with head and neck cancer. Clin Cancer Res 5: 329-334
11. Lee PP, Yee C, Savage PA, Fong L, Brockstedt D, Weber JS, Johnson D, Swetter S, Thompson J, Greenberg PD, Roederer M, Davis MM (1999) Characterization of circulating T cells specific for tumour associated antigens in melanoma patients. Nat Med 5: 677-685
12. Mackall CL, Hakim FT, Gress RE (1997) Restoration of T-cell homeostasis after T-cell depletion. Semin Immunol 9: 339-346
13. Meidenbauer N Gooding W Spliter L Harris D Whiteside TL (2002) Recovery of ζ chain expression and changes in spontaneous IL-10 production after PSA-based vaccines in patients with prostate cancer. Br J Cancer, 86: 168-178
14. Mohri H, Bonhoeffer S, Monard S, Perelson A, Ho DD (1998) Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science 279: 1223-1227
15. Otsuji M, Kimura Y, Aoe T, Okamoto Y, Saito T (1996) Oxidative stress by tumour-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci USA 93: 13119-13124
16. Penna D, Mullers S, Martinon F, Demotz S, Iwashima M, Valitutti S (1999) Degradation of ZAP-70 following antigenic stimulation in human T lymphocytes: role of calpain proteolytic pathway. J Immunol 163: 50-56
17. Rabinowich H, Banks M, Reichert T, Logan T, Kirkwood J, Whiteside T (1996) Expression and activity of signalling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy. Clin Cancer Res 2: 1263-1272
18. Rabinowich H, Reichert TE, Kashii Y, Bell MC, Whiteside TL (1998) Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells: implications for altered expression of TcR in tumour-associated lymphocytes. J Clin Invest 101: 2579-2588
19. Reichert TE, Day R, Wagner EM, Whiteside TL (1998a) Absent or low expression of the ζ chain in T cells at the tumour site correlates with poor survival in patients with oral carcinoma. Cancer Res 58: 5344-5347
20. Reichert TE, Rabinowich H, Johnson JT, Whiteside TL (1998b) Immune cells in the tumour microenvironment. Mechanisms responsible for signalling and functional defects. J Immunother 21: 295-306
21. Reichert TE, Strauss L, Wagner EM, Gooding W, Whiteside TL (2002) Signalling abnormalities, apoptosis and reduced proliferation of circulating and tumour-infiltrating lymphocytes in patients with oral carcinoma. Clin Cancer Res 8: 3137-3145
22. Sallusto F, Lenig D, Foerster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712
23. Schmielau J, Finn OJ. (2001) Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 61: 4756-4760
24. Stefanova I, Saville MW, Peters C, Cleghorn FR, Schwartz D, Venzon DJ, Weinhold KJ, Jack N, Bartholomew C, Blattner WA, Yarchoan R, Bolen JB, Horak ID (1996) HIV infection-induced posttranslational modification of T cell signalling molecules associated with disease progression. J Clin Invest 98: 1290-1297
25. Taheri F, Ochoa JB, Faghiri Z, Culotta K, Park H-J Lan MS, Zea AH, Ochoa AC (2001) L-arginine regulates the expression of the T-cell receptor ζ chain (CD3ζ) in Jurkat cells. Clin Cancer Res 7: 958s-965s
26. Taylor DD, Bender DP, el-Taylor GEI, Stanson J, Whiteside TL (2001) Modulation of TcR/CD3-zeta chain expresion by a circulating factor derived from ovarian cancer patients. Br J Cancer 84: 1624-1629
27. Tough DF, Sprent J. (1994) Turnover of naive and memory-phenotype T cells. J Exp Med 170: 1127-1135
28. Valiutti S, Muller S, Salio M, Lanzavecchia A (1997) Degradation of T-cell receptors (TcR)-CD3 zeta complexes after antigenic stimulation. J Exp Med 185: 1859-1864
29. Van Parijs L, Abbas AK (1998) Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280: 243-248
30. Whiteside TL (1999) Signalling defects in T lymphocytes of patients with malignancy. Cancer Immunol Immunother 48: 346-352
31. bright T cell subsets and their relationship to memory and naïve T cells. Eur J Immunol 27: 2383-2389
32. Zea AH, Curti BD, Longo DL, Alvord WG, Strobl SL, Mizoguchi H, Creekmore SP, O'Shea JJ, Powers GC, Urba WJ, Ochoa AC (1995) Alterations in T-cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res 1: 1327-1335
33. Zea AH, Ochoa MT, Ghosh P, Longo DL, Alvord WG, Valderrama L, Falabella R, Harvey LK, Saravia N, Moreno LH, Ochoa AC (1998). Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infect Immun 66: 499-504