Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents

Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2003, Pages 1706-1715

  Li, Wen Tai ^a   Hwang, Der Ren ^a   Chen, Ching Ping ^a   Shen, Chien Wei ^a   Huang, Chen Long ^a   Chen, Tung Wei ^a   Lin, Chi Hung ^b   Chang, Yee Ling ^a   Chang, Ying Ying ^a   Lo, Yue Kan ^a   Tseng, Huan Yi ^a   Lin, Chu Chung ^a   Song, Jeng Shin ^a   Chen, Hua Chien ^a   Chen, Shu Jen ^a   Wu, Se Hui ^a   Chen, Chiung Tong ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

(3 METHYL 5 ISOTHIAZOLYL) 1 [(3 METHYL 5 ISOXAZOLYL)METHYL] 1H 3 INDOLYL 2 OXOACETAMIDE; (3 METHYL 5 ISOTHIAZOLYL)[1 (4 CYANOBENZYL) 1H 3 INDOLYL] 2 OXOACETAMIDE; ANTINEOPLASTIC AGENT; DNA FRAGMENT; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; INDOLYLGLYOXYLAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; DOSE RESPONSE; DRUG ACTIVITY; DRUG INDICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IC 50; LEUKEMIA P 388; MULTIDRUG RESISTANCE; NONHUMAN; STOMACH CANCER; STRUCTURE ACTIVITY RELATION; UTERUS CANCER;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLYOXYLATES; HUMANS; INDOLES; LEUKEMIA P388; MICE; MICE, INBRED DBA; NEOPLASM TRANSPLANTATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0037464479     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020471r     Document Type: Article

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