Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells

Journal of Medicinal Chemistry

Volumn 44, Issue 14, 2001, Pages 2308-2318

  Simoni, D ^a   Roberti, M ^b   Invidiata, F P ^c   Rondanin, R ^a   Baruchello, R ^a   Malagutti, C ^a   Mazzali, A ^a   Rossi, M ^a   Grimaudo, S ^d   Capone, F ^d   Dusonchet, L ^c   Meli, M ^c   Raimondi, M V ^d   Landino, M ^c   D'Alessandro, N ^c   Tolomeo, M ^d   Arindam, D ^e   Lu, S ^e   Benbrook, D M ^e  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d Divisione di Ematologia   (Italy)

^e UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALEN 2 YL)ISOXAZOL 3 YL]BENZOIC ACID; AROTINOID; HETEROCYCLIC COMPOUND; ISOXAZOLE RETINOID; RETINOIC ACID RECEPTOR; RETINOID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; MOLECULAR MODEL; RECEPTOR AFFINITY; STEREOCHEMISTRY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOATES; CELL DIFFERENTIATION; CELL DIVISION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; RECEPTORS, RETINOIC ACID; RETINOIDS; TETRAHYDRONAPHTHALENES; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0035811450     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0010320     Document Type: Article

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