Orally-effective, long-acting sorbitol dehydrogenase inhibitors: Synthesis, structure - Activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 511-528

  Chu Moyer, Margaret Y ^a,f   Ballinger, William E ^b,f   Beebe, David A ^a,f   Berger, Richard ^a,c,f   Coutcher, James B ^a,f   Day, Wesley W ^d,f   Li, Jiancheng ^a,f   Mylari, Banavara L ^a,f   Oates, Peter J ^a,f   Weekly, R Matthew ^a,e,f  

^a Department of Medicinal Chemistry ^*  (United States)

^b PGRD   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d Drug Safety and Risk Management   (United States)

^e Chemical Research and Development   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FRUCTOSE; HETEROCYCLIC COMPOUND; IDITOL DEHYDROGENASE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG HALF LIFE; DRUG POTENCY; GLUCOSE METABOLISM; INSULIN TREATMENT; METABOLIC ACTIVATION; NERVE FUNCTION; NONHUMAN; OXIDATION REDUCTION REACTION; RAT; SCIATIC NERVE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHRONIC DISEASE; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; FRUCTOSE; L-IDITOL 2-DEHYDROGENASE; MALE; PIPERAZINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037122756     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010440g     Document Type: Article

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