hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

Gene Therapy

Volumn 9, Issue 1, 2002, Pages 30-37

  Gu, J ^a   Andreeff, M ^a   Roth, J A ^a   Fang, B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; Bax; hTERT promoter; Progenitor cells; Syngenic tumor; Tumor targeting

Indexed keywords

ADENOVIRUS VECTOR; CD34 ANTIGEN; PROTEIN BAX; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER; CANCER INHIBITION; CELL KILLING; CELL TRANSFORMATION; CHRONIC TOXICITY; CONTROLLED STUDY; CYTOTOXICITY; FIBROSARCOMA; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; IMMUNOCOMPETENCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; TUMOR CELL LINE; TUMOR XENOGRAFT;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 0036166825     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301619     Document Type: Article

References (31)

1. Apoptosis in the pathogenesis and treatment of disease
2. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
3. Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells: Implications for gene therapy
4. Adenoviral Bak overexpression mediates caspase-dependent tumor killing
5. Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines
6. Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: Implication for gene therapy
7. In vitro and in vivo targeting of gene expression to melanoma cells
8. Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene
9. Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter
10. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector
11. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers
12. A novel telomerase-specific gene therapy: Gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter
13. Specific association of human telomerase activity with immortal cells and cancer
14. A survey of telomerase activity in human cancer
15. Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia
16. A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax
17. Eradication of primary murine fibrosarcomas and induction of systemic immunity by adenovirus-mediated interferon β gene therapy
18. Gene transfer into human bone marrow hematopoietic cells mediated by adenovirus vectors
19. Adenovirus-mediated alpha interferon (IFN-α) gene transfer into CD34+ cells and CML mononuclear cells
20. Genetic manipulation of primitive leukemic and normal hematopoietic cells using a novel method of adenovirus-mediated gene transfer
21. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation
22. NF-κB regulates transcription of the mouse telomerase catalytic subunit
23. Myc activates telomerase
24. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
25. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
26. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
27. Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter
28. Telomerase activity in hematopoietic cells is associated with self-renewal potential
29. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow
30. Telomerase activity in human acute myelogenous leukemia: Inhibition of telomerase activity by differentiation-inducing agents
31. Expression of Bcl-2-related genes in normal and AML progenitors: Changes induced by chemotherapy and retinoic acid