Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7379-7382

  Mori, M ^a   Mimori, K ^a   Masuda, T ^a   Yoshinaga, K ^a   Yamashita, K ^a   Matsuyama, A ^a   Inoue, H ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; GENE PRODUCT; PROTEIN MSH2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACID ANHYDRIDE HYDROLASES; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 0035887084     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Replacement of Fhit in cancer cells suppresses tumorigenicity
2. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression
3. The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
4. The FHIT gene, spanning the chromosonae 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
5. Alternative splicing of the FHIT gene in colorectal cancers
6. Clinicopathologic features and FHIT gene expression in sporadic colorectal adenocarcinomas
7. Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions
8. Evaluation of the FHIT gene in colorectal cancers
9. Muir-Torte-like syndrome in Fhit-deficient mice
10. Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria
11. Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas
12. Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus
13. Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype
14. Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix
15. Structure and expression of the human FHIT gene in normal and tumor cells
16. Role of FHIT in human cancer
17. Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion
18. Cancer-specific chromosome alterations in the constitutive fragile region FRA3B