Dysregulation of intestinal mucosal immunity: Implications in inflammatory bowel disease

News in Physiological Sciences

Volumn 16, Issue 6, 2001, Pages 272-277

  Laroux, F Stephen ^a   Pavlick, Kevin P ^a   Wolf, Robert E ^a   Grisham, Matthew B ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANTIBODY PRODUCTION; ENTERITIS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INTESTINE; INTESTINE MUCOSA; MICROCIRCULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; VASCULARIZATION;

ANIMAL; ANTIBODY FORMATION; HUMAN; IMMUNE SYSTEM; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; INTESTINES; MICROCIRCULATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035656221     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiologyonline.2001.16.6.272     Document Type: Article

References (20)

1. Abbas AK. Cellular and Molecular Immunology. Philadelphia: Saunders, 2000.
2. Bennett CF, Kornbrust D, Henry S, Stecker K, Howard R, Cooper S, Dutson S, Hall W, and Jacoby HI. An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice. J Pharmacol Exp Ther 280: 988-1000, 1997.
3. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205, 1998.
4. Granger DN, Grisham MB, and Kvietys PR. Mechanisms of microvascular injury. In: Physiology of the Gastrointestinal Tract, edited by Johnson LR. New York: Raven, 1994, p. 1693-1722.
5. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, and Roncarolo MG. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-742, 1997.
6. Hesterberg PE, Winsor-Hines D, Briskin MJ, Soler-Ferran D, Merrill C, Mackay CR, Newman W, and Ringler DJ. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7. Gastroenterology 111: 1373-1380, 1996.
7. Hulten L, Lindhagen J, Lundgren O, Fasth S, and Ahren C. Regional intestinal blood flow in ulcerative colitis and Crohn's disease. Gastroenterology 72: 388-396, 1977.
8. Kawachi S, Jennings S, Panes J, Cockrell A, Laroux FS, Gray L, Perry M, van der Heyde H, Balish E, Granger DN, Specian RA, and Grisham MB. Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice. Am J Physiol Gastrointest Liver Physiol 278: G734-G743, 2000.
9. Kawachi S, Morise Z, Jennings SR, Conner E, Cockrell A, Laroux FS, Chervenak RP, Wolcott M, van der Heyde H, Gray L, Feng L, Granger DN, Specian RA, and Grisham MB. Cytokine and adhesion molecule expression in SCID mice reconstituted with CD4+ T cells. Inflamm Bowel Dis 6: 171-180, 2000.
10. Kirsner JB and Shorter RG. Inflammatory Bowel Disease. Baltimore: Williams & Wilkins, 1995.
11. Laroux FS and Grisham MB. Immunological basis of inflammatory bowel disease: role of the microcirculation. Microcirculation 8: 283-301, 2001.
12. Leach MW, Davidson NJ, Fort MM, Powrie F, and Rennick DM. The role of IL-10 in inflammatory bowel disease: "of mice and men." Toxicol Pathol 27: 123-133, 1999.
13. Mason D and Powrie F. Control of immune pathology by regulatory T cells. Curr Opin Immunol 10: 649-655, 1998.
14. high CD4+ T cells. J Immunol 158: 2099-2106, 1997.
15. Powrie F, Carlino J, Leach MW, Mauze S, and Coffman RL. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 183: 2669-2674, 1996.
16. Seder RA and Mosmann TM. Differentiation of effector phenotypes of CD4+ and CD8+ T cells. In: Fundamental Immunology, edited by Paul WE. Philadelphia: Lippincott-Raven, 1999, p. 879-908.
17. Strober W, Kelsall B, Fuss I, Marth T, Ludviksson B, Ehrhardt R, and Neurath M. Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today 18: 61-64, 1997.
18. Strober W, Ludviksson BR, and Fuss IJ. The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease. Ann Intern Med 128: 848-856, 1998.
19. Wirtz S and Neurath MF. Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease. Int J Colorectal Dis 15: 144-160, 2000.
20. Yacyshyn BR, Bowen-Yacyshyn MB, Jewell L, Tami JA, Bennett CF, Kisner DL, and Shanahan WR Jr. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 114: 1133-1142, 1998.