T cell tolerance and the thymus

Annals of the New York Academy of Sciences

Volumn 841, Issue , 1998, Pages 236-245

  Sprent, Onathan ^a   Kishimoto, Hidehiro ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Cancer Research Institute

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE PROTEIN; FAS ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

APOPTOSIS; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL SELECTION; CONFERENCE PAPER; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; NONHUMAN; T LYMPHOCYTE; THYMUS FUNCTION; TRANSGENE;

EID: 0031879688     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10933.x     Document Type: Conference Paper

References (47)

1. VON BOEHMER, H. 1990. Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol. 8: 531-556.
2. SPRENT, J. 1993. T lymphocytes and the thymus. In Fundamental Immunology. Volume 3, p. 75-110. Raven Press. New York.
3. JAMESON, S. C., K. A. HOGQUIST & M. J. BEVAN. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13: 93-126.
4. SPRENT, J., D. Lo, E. K. GAO & Y. RON. 1988. T cell selection in the thymus. Immunol. Rev. 101: 173-190.
5. FINK, P. J. & M. J. BEVAN. 1995. Positive selection of thymocytes. Adv. Immunol. 59: 99-133.
6. PFEFFER, K. & T. W. MAK. 1994. Lymphocyte ontogeny and activation in gene-targeted mice. Annu. Rev. Immunol. 12: 367-411.
7. HOGQUIST, K. A., S. C. JAMESON, W. R. HEATH, J. L. HOWARD, M. J. BEVAN & F. R. CARBONE. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
8. SEBZDA, E., V A. WALLACE, J. MAYER, R. S. YEUNG, T. W. MAK & P. S. OHASHI. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263: 1615-1618.
9. ASHTON-RICKARDT, P. G. & S. TONEGAWA. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15: 362-366.
10. JANEWAY, C. A., JR. 1994. Thymic selection: two pathways to life and two to death. Immunity 1: 3-6.
11. SHORTMAN, K., M. EGERTON, G. J. SPANGRUDE & R. SCOLLAY. 1990. The generation and fate of thymocytes. Semin. Immunol. 2: 3-12.
12. SURH, C. D. & J. SPRENT. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372: 100-103.
13. + thymocytes. Eur. J. Immunol. 23: 739-746.
14. MARRACK, P., L. IGNATOWICZ, J. W. KAPPLER, J. BOYMEL & J. H. FREED. 1994. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178: 2173.
15. SEBZDA, E., T. M. KUNDIG, C. T. THOMSON, K. AOKI, S-Y. MAK, J. P. MAYER, T. ZAMBORELLI, S. G. NATHENSON & P. S. OHASHI. 1996. Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183: 1093-1104.
16. KISHIMOTO, H. & J. SPRENT. 1997. Negative selection in the thymus includes semi-mature T cells. J. Exp. Med. 185: 263-272.
17. KAPPLER, J. W., N. ROEHM & P. MARRACK. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49: 273-280.
18. NOSSAL, G. J. V. 1994. Negative selection of lymphocytes. Cell 76: 229-239.
19. SPRENT, J. & S. R. WEBB. 1995. Intrathymic and extrathymic clonal deletion of T cells. Curr. Opin. Immunol. 7: 196-205.
20. SPRENT, J. 1995. Central tolerance of T cells. Int. Rev. Immunol. 13: 95-105.
21. WEIGLE, W. O. 1973. Immunological unresponsiveness. Adv. Immunol. 16: 61-122.
22. SINHA, A. A., M. T. LOPEZ & H. O. MCDEVITT. 1990. Autoimmune diseases: the failure of self tolerance. Science 248: 1380-1388.
23. MILLER, J. F. A. P. & W. R. HEATH. 1993. Self-ignorance in the peripheral T-cell pool. Immunol. Rev. 133: 131-150.
24. JOLICOEUR, C., D. HANAHAN & K. M. SMITH. 1994. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. U.S.A. 91: 6707-6711.
25. ANTONIA, S. J., T. GEIGER, J. MILLER & R. A. FLAVELL. 1995. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int. Immunol. 7: 715-725.
26. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179: 709-713.
27. VASQUEZ, N. J., L. P. KANE & S. M. HEDRICK. 1994. Intracellular signals that mediate negative selection. Immunity 1: 45-56.
28. PIRCHER, H., K. BURKI, R. LANG, H. HENGARTNER & R. M. ZINKERNAGEL. 1989. Tolerance induction in double specific T cell receptor transgenic mice varies with antigen. Nature 342: 559-561.
29. 1o thymocytes in vivo. Science 250: 1720-1723.
30. + thymocytes in vivo by anti-CD3 or 5′(N-ethyl)-carboxamide-adenosine is blocked by glucocorticoid receptor antagonist RU-486. Eur. J. Immunol. 23: 1246-1250.
31. LAUFER, T. M., J. DEKONING, J. S. MARKOWITZ, D. LO & L. H. GLIMCHER. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383: 81-85.
32. CRISPE, I. N. & M. J. BEVAN. 1987. Expression and functional significance of the J11d marker on mouse thymocytes. J. Immunol. 138: 2013-2018.
33. VERNACHIO, J., M. LI, A. D. DONNENBERG & M. J. SOLOSKI. 1989. Qa-2 expression in the adult murine thymus: a unique marker for a mature thymic subset. J. Immunol. 142: 48-56.
34. NIKOLIC-ZUGIC, J. & M. J. BEVAN. 1990. Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus. Int. Immunol. 2: 135-141.
35. - thymocytes are functionally immature. J. Immunol. 147: 1779-1785.
36. NAGATA, S. & P. GOLSTEIN. 1995. The Fas death factor. Science 267: 1449-1456.
37. L. Immunity 3: 87-98.
38. LINSLEY, P. S. & J. A. LEDBETTER. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212.
39. SINGER, G. G. & A. K. ABBAS. 1994. The Fas antigen is involved in peripheral, but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1: 365-371.
40. THEOFILOPOULOS, A. N. 1995. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol. Today 16: 90-98.
41. CASTRO, J. E., J. A. LISTMAN, B. A. JACOBSON, Y. WANG, P. A. LOPEZ, S. JU, P. W. FINN & D. L. PERKINS. 1996. Fas modulation of apoptosis during negative selection of thymocytes. Immunity 5: 617-627.
42. + thymocytes. J. Immunol. 151: 1868-1880.
43. AIBA, Y., O. MAZDA, M. M. DAVIS, S. MURAMATSU & Y. KATSURA. 1994. Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells. Int. Immunol. 6: 1475-1483.
44. SHAHINIAN, A., K. PFEFFER, K. P. LEE, T. M. KUNDIG, K. KISHIHARA, A. WAKEHAM, K. KAWAI, P. S. OHASHI, C. B. THOMPSON & T. W. MAK. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-612.
45. WALUNAS, T. L., A. I. SPERLING, R. KHATTRI, C. B. THOMPSON & J. A. BLUESTONE. 1996. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J. Immunol. 156: 1006-1013.
46. FOY, T. M., D. M. PAGE, T. J. WALDSCHMIDT, A. SCHONEVELD, J. D. LAMAN, S. R. MASTERS, L. TYGRETT, J. A. LEDBETTER, A. ARUFFO, E. CLAASSEN, J. C. XU, R. A. FLAVELL, S. OEHEN, S. M. HEDRICK & R. J. NOELLE. 1995. An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182: 1377-1388.
47. AGUS, D. B., C. D. SURH & J. SPRENT. 1991. Reentry of T cells to the adult thymus is restricted to activated T cells. J. Exp. Med. 173: 1039-1046.