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Volumn 370, Issue 3, 2003, Pages 891-899

The haemochromatosis protein hfe induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of β2-microglobulin

Author keywords

Ferritin; Iron regulatory protein; Iron responsive element; Transferrin receptor

Indexed keywords

BLOOD; CELL CULTURE; CLONING; IRON; PROTEINS;

EID: 0037444795     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021607     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 0032530340 scopus 로고    scopus 로고
    • Iron is hot: An update on the pathophysiology of hemochromatosis
    • Andrews, N. C. and Levy, J. E. (1998) Iron is hot: an update on the pathophysiology of hemochromatosis. Blood 92, 1845-1851
    • (1998) Blood , vol.92 , pp. 1845-1851
    • Andrews, N.C.1    Levy, J.E.2
  • 2
    • 0036196205 scopus 로고    scopus 로고
    • Mechanisms of iron accumulation in hereditary hemochromatosis
    • Fleming, R. E. and Sly, W. S. (2002) Mechanisms of iron accumulation in hereditary hemochromatosis. Annu. Rev. Physiol. 64, 663-680
    • (2002) Annu. Rev. Physiol. , vol.64 , pp. 663-680
    • Fleming, R.E.1    Sly, W.S.2
  • 7
    • 0036177909 scopus 로고    scopus 로고
    • A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation
    • Gochee, P. A., Powell, L. W., Cullen, D. J., Du Sart, D., Rossi, E. and Olynyk, J. K. (2002) A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation. Gastroenterology 122, 646-651
    • (2002) Gastroenterology , vol.122 , pp. 646-651
    • Gochee, P.A.1    Powell, L.W.2    Cullen, D.J.3    Du Sart, D.4    Rossi, E.5    Olynyk, J.K.6
  • 10
    • 0033168767 scopus 로고    scopus 로고
    • The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
    • Levy, J. E., Montross, L. K., Cohen, D. E., Fleming, M. D. and Andrews, N. C. (1999) The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 94, 9-11
    • (1999) Blood , vol.94 , pp. 9-11
    • Levy, J.E.1    Montross, L.K.2    Cohen, D.E.3    Fleming, M.D.4    Andrews, N.C.5
  • 13
    • 0029670047 scopus 로고    scopus 로고
    • 2 knockout mice develop parenchymal iron overload: A putative role tor class I genes of the major histocompatibility complex in iron metabolism
    • 2 knockout mice develop parenchymal iron overload: a putative role tor class I genes of the major histocompatibility complex in iron metabolism. Proc. Natl. Acad. Sci. U.S.A. 93, 1529-1534
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1529-1534
    • Rothenberg, B.E.1    Voland, J.R.2
  • 17
    • 0034062537 scopus 로고    scopus 로고
    • Genes that modify the hemochromatosis phenotype in mice
    • Levy, J. E., Montross, L. K. and Andrews, N. C. (2000) Genes that modify the hemochromatosis phenotype in mice J. Clin. Invest. 105, 1209-1216
    • (2000) J. Clin. Invest. , vol.105 , pp. 1209-1216
    • Levy, J.E.1    Montross, L.K.2    Andrews, N.C.3
  • 19
  • 22
    • 0033605595 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
    • Roy, C. N., Penny, D. M., Feder, J. N. and Enns, C. A. (1999) The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. J. Biol. Chem. 274, 9022-9028
    • (1999) J. Biol. Chem. , vol.274 , pp. 9022-9028
    • Roy, C.N.1    Penny, D.M.2    Feder, J.N.3    Enns, C.A.4
  • 23
    • 0033545852 scopus 로고    scopus 로고
    • Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis
    • Salter-Cid, L., Brunmark, A., Li, Y., Leturcq, D., Peterson, P. A., Jackson, M. R. and Yang, Y. (1999) Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis. Proc. Natl. Acad. Sci. U.S.A. 96, 5434-5439
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 5434-5439
    • Salter-Cid, L.1    Brunmark, A.2    Li, Y.3    Leturcq, D.4    Peterson, P.A.5    Jackson, M.R.6    Yang, Y.7
  • 24
    • 0032830130 scopus 로고    scopus 로고
    • The transferrin receptor: Role in health and disease
    • Ponka, P. and Lok, C. N. (1999) The transferrin receptor: role in health and disease. Int. J. Biochem. Cell Biol. 31, 1111-1137
    • (1999) Int. J. Biochem. Cell Biol. , vol.31 , pp. 1111-1137
    • Ponka, P.1    Lok, C.N.2
  • 25
    • 0034610781 scopus 로고    scopus 로고
    • Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor
    • Bennett, M. J., Lebron, J. A. and Bjorkman, P. J. (2000) Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature (London) 403, 46-53
    • (2000) Nature (London) , vol.403 , pp. 46-53
    • Bennett, M.J.1    Lebron, J.A.2    Bjorkman, P.J.3
  • 26
    • 0032555601 scopus 로고    scopus 로고
    • Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation
    • Gross, C. N., Irrinki, A., Feder, J. N. and Enns, C. A. (1998) Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J. Biol. Chem. 273, 22068-22074
    • (1998) J. Biol. Chem. , vol.273 , pp. 22068-22074
    • Gross, C.N.1    Irrinki, A.2    Feder, J.N.3    Enns, C.A.4
  • 28
    • 0033585129 scopus 로고    scopus 로고
    • The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor
    • Lebrón, J. A., West, Jr, A. P. and Bjorkman, P. J. (1999) The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor. J. Mol. Biol 294, 239-245
    • (1999) J. Mol. Biol. , vol.294 , pp. 239-245
    • Lebrón, J.A.1    West A.P., Jr.2    Bjorkman, P.J.3
  • 30
    • 0032866573 scopus 로고    scopus 로고
    • Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces and an iron-deficient phenotype
    • Corsi, B., Levi, S., Cozzi, A., Corti, A., Altimare, D., Albertini, A. and Arosio, P. (1999) Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces and an iron-deficient phenotype. FEBS Lett. 460, 149-152
    • (1999) FEBS Lett. , vol.460 , pp. 149-152
    • Corsi, B.1    Levi, S.2    Cozzi, A.3    Corti, A.4    Altimare, D.5    Albertini, A.6    Arosio, P.7
  • 31
    • 0034634505 scopus 로고    scopus 로고
    • Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells
    • Roy, C. N., Carlson, E. J., Anderson, E. L., Basava, A., Starnes, S. M., Feder, J. N. and Enns, C. A. (2000) Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells. FEBS Lett. 484, 271-274
    • (2000) FEBS Lett. , vol.484 , pp. 271-274
    • Roy, C.N.1    Carlson, E.J.2    Anderson, E.L.3    Basava, A.4    Starnes, S.M.5    Feder, J.N.6    Enns, C.A.7
  • 32
    • 0029758487 scopus 로고    scopus 로고
    • Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress
    • Hentze, M. W. and Kühn, L. C. (1996) Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 93, 8175-8182
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 8175-8182
    • Hentze, M.W.1    Kühn, L.C.2
  • 33
    • 0034731457 scopus 로고    scopus 로고
    • Combinatorial mRNA regulation: Iron regulatory proteins and iso-iron responsive elements (iso-IREs)
    • Theil, E. C. and Eisenstein, R. S. (2000) Combinatorial mRNA regulation: iron regulatory proteins and iso-iron responsive elements (iso-IREs). J. Biol. Chem. 275, 40659-40662
    • (2000) J. Biol. Chem. , vol.275 , pp. 40659-40662
    • Theil, E.C.1    Eisenstein, R.S.2
  • 34
    • 0036135887 scopus 로고    scopus 로고
    • Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells
    • Roy, C. N., Blemings, K. P., Deck, K. M, Davies, P. S. Anderson, E. L., Eisenstein, R. S. and Enns, C. A. (2002) Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells. J Cell. Physiol. 190, 218-226
    • (2002) J Cell. Physiol. , vol.190 , pp. 218-226
    • Roy, C.N.1    Blemings, K.P.2    Deck, K.M.3    Davies, P.S.4    Anderson, E.L.5    Eisenstein, R.S.6    Enns, C.A.7
  • 36
    • 0036275236 scopus 로고    scopus 로고
    • Conditional de-repression of ferritin synthesis in cells expressing a constitutive IRP1 mutant
    • Wang, J. and Pantopoulos, K. (2002) Conditional de-repression of ferritin synthesis in cells expressing a constitutive IRP1 mutant. Mol. Cell. Biol. 22, 4638-4651
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4638-4651
    • Wang, J.1    Pantopoulos, K.2
  • 37
    • 0035827697 scopus 로고    scopus 로고
    • 2on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts
    • 2on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts. J. Biol. Chem. 276, 19738-19745
    • (2001) J. Biol. Chem. , vol.276 , pp. 19738-19745
    • Caltagirone, A.1    Weiss, G.2    Pantopoulos, K.3
  • 38
    • 0036358643 scopus 로고    scopus 로고
    • Activation of iron regulatory protein-1 (IRP1) by oxidative stress
    • Mueller, S. and Pantopoulos, K. (2002) Activation of iron regulatory protein-1 (IRP1) by oxidative stress. Methods Enzymol. 348, 324-337
    • (2002) Methods Enzymol. , vol.348 , pp. 324-337
    • Mueller, S.1    Pantopoulos, K.2
  • 39
    • 0031963449 scopus 로고    scopus 로고
    • Function and regulation of transferrin and ferritin
    • Ponka, P., Beaumont, C. and Richardson, D. R. (1998) Function and regulation of transferrin and ferritin. Semin. Hematol. 35, 35-54
    • (1998) Semin. Hematol. , vol.35 , pp. 35-54
    • Ponka, P.1    Beaumont, C.2    Richardson, D.R.3
  • 42
    • 0034572933 scopus 로고    scopus 로고
    • Iron homeostasis: Insights from genetics and animal models
    • Andrews, N. C. (2000) Iron homeostasis: insights from genetics and animal models. Nat. Rev. Genet 1, 208-217
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 208-217
    • Andrews, N.C.1
  • 43
    • 0037117603 scopus 로고    scopus 로고
    • Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
    • Trinder, D., Olynyk, J. K., Sly, W. S. and Morgan, E. H. (2002) Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc. Natl. Acad Sci. U.S.A. 9, 5622-5626
    • (2002) Proc. Natl. Acad Sci. U.S.A. , vol.9 , pp. 5622-5626
    • Trinder, D.1    Olynyk, J.K.2    Sly, W.S.3    Morgan, E.H.4
  • 44
    • 0030894809 scopus 로고    scopus 로고
    • Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis
    • Cairo, G., Recalcati, S., Montosi, G., Castrusini, E., Conte, D. and Pietrangelo, A. (1997) Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis. Blood 89, 2546-2553
    • (1997) Blood , vol.89 , pp. 2546-2553
    • Cairo, G.1    Recalcati, S.2    Montosi, G.3    Castrusini, E.4    Conte, D.5    Pietrangelo, A.6
  • 45
    • 0034254794 scopus 로고    scopus 로고
    • Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis
    • Montosi, G., Paglia, P., Garuti, C., Guzman, C. A., Bastin, J. M., Colombo, M. P. and Pietrangelo, A. (2000) Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis. Blood 96, 1125-1129
    • (2000) Blood , vol.96 , pp. 1125-1129
    • Montosi, G.1    Paglia, P.2    Garuti, C.3    Guzman, C.A.4    Bastin, J.M.5    Colombo, M.P.6    Pietrangelo, A.7
  • 46
    • 0031002910 scopus 로고    scopus 로고
    • Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    • Parkkila, S., Waheed, A., Britton, R. S., Feder, J. N., Tsuchihashi, Z., Schatzman, R. C., Bacon, B. R. and Sly, W. S. (1997) Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc. Natl. Acad. Sol. U.S.A. 94, 2534-2539
    • (1997) Proc. Natl. Acad. Sol. U.S.A. , vol.94 , pp. 2534-2539
    • Parkkila, S.1    Waheed, A.2    Britton, R.S.3    Feder, J.N.4    Tsuchihashi, Z.5    Schatzman, R.C.6    Bacon, B.R.7    Sly, W.S.8
  • 47
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A. and Vaulont, S. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U.S.A. 98, 8780-8785
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.