Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients

Clinical and Experimental Immunology

Volumn 104, Issue 1, 1996, Pages 72-79

  Garcia Cozar F J ^b,d   Molina, I J ^c   Cuadrado, M J ^a   Marubayashi, M ^a   Pena J ^a   Santamaria M ^a,b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Universidad de Cordoba   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

B7 CD28; systemic lupus erythematosus; T cells

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; HYBRID PROTEIN; INTERLEUKIN 2; MONOCLONAL ANTIBODY;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 0029931053     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-648.x     Document Type: Article

References (44)

1. Alcocer-Varela J, Alarcon-Segovia D. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 1982; 69:1388-92.
2. Linker-Israeli M, Bakke AC, Kifridou RC, Gendler KS, Gillis S, Horwitz DA. Defective production of interleukin-1 and interleukin-2 in patients with systemic lupus erythematosus. J Immunol 1983; 130:2651-5.
3. Fox DA, Millard LA, Treisman J et al. Defective CD2 pathway T cell activation in systemic lupus erythematosus. Arthritis Rheum 1991; 34:561-71.
4. Via CS, Tsokos GC, Bermas B, Clerici M, Shearer GM. T cell antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects. J Immunol 1993; 151:3914-22.
5. Kuntz MM, Innes JB, Weksler ME. The cellular basis of the impaired mixed lymphocyte reaction in patients with systemic lupus erythematosus. J Clin Invest 1979; 63:151-8.
6. Crow MK. Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus. J Clin Invest 1985; 76:807.
7. Garcia-Cozar FJ, Peña J, Montero I, Santamaria M. Costimulation of T cells: role of CD28/CTLA-4: B7-1/B7-2 interactions. Inmunologia 1995; 14:151-65.
8. June CH, Bluestone JA, Nadler LM, Thompson CB. The B7 and CD28 receptor families. Immunol Today 1994; 15:321-31.
9. Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of Interleukin-2 enhancer activity by the T cell accessory molecule CD28. Science 1991; 251:313-6.
10. Lindsten T, June CH, Ledbetter JA, Stella G, Thompson CB. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 1989; 224:339-43.
11. Schwartz RH. A cell culture model for T cell clonal anergy. Science 1990; 248:1349-56.
12. Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA. Binding of B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 1991; 173:721-30.
13. Jenkins MK, Taylor PS, Norton SD, Urdahl KB. CD28 delivers a costimulatory signal involved in antigen-specific 1L-2 production by human T cells. J Immunol 1991; 147:2461-6.
14. Shahinian A, Pfeffer K, Lee KP et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993; 261:609-12.
15. Muraille E, De Smedt T, Thielemans K, Urbain J, Moser M, Leo O. Activation of murine T cells by bacterial superantigens requires B7-mediated costimulation. Cell Immunol 1995; 162:315-20.
16. Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP. CD28- mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992; 356:607-9.
17. Gimmi CD, Freeman GJ, Gribben JG, Gray G, Nadler LM. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci USA 1993; 90:6585-90.
18. Finck BK, Linsley PS, Wofsy W. Treatment of murine lupus with CTLA4-Ig. Science 1994; 265:1225-7.
19. Sfikakis PP, Oglesby R, Sfikakis P, Tsokos GC. B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1994; 96:8-14.
20. Stekman IL, Blasini AM, Leon-Ponte M, Baroja ML, Abadi I, Rodriguez MA. Enhanced CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus. Arthritis Rheum 1991; 34:459-67.
21. Stohl W. Impaired anti-CD3 induced T cell-mediated unrestricted cytolytic activity despite normal anti-CD3-induced T cell proliferation in systemic lupus erythematosus. Clin Immunol Immunopathol 1992; 63:163-72.
22. Kaneoka H. T cell activation through CD3 molecules in patients with systemic lupus erythematosus. Arthritis Rheum 1992; 35:1401-2.
23. Blasini AM, Stekman IL, Leon-Ponte M, Caldera D, Rodriguez MA. Increased proportion of responders to a murine anti-CD3 monoclonal antibody of the IgGl class in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1993; 94:423-8.
24. Tan EM, Cohen A, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25:1271-7.
25. Urowitz MB, Gladman DO, Tozman ECS, Goldsmith CH. The lupus activity criteria count (LACC). J Rheumatol 1984; 11:783-7.
26. Garcia-Cozar FJ, Borrego F, Madueǹo JA, Solana R, Peña J, Santamaría M. Co-stimulatory effect of activation MoAbs on T cell proliferation. In: Schlossman SF, Boumsell L, Gilks W et al., eds. Leukocyte typing V. Oxford. Oxford University Press, 1995; 1133-6.
27. Auffray C, Rougeon F. Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 1980; 107:303-7.
28. Vandenberghe P, Freeman GJ, Nadler LM et al. Antibody and B7/ BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. J Exp Med 1992; 175:951-60.
29. Lu Y, Granelli-Piperno A, Bjorndahl JM, Phillips CA, Trevillyan JM. CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway. J Immunol 1992; 149:24-29.
30. Sigal NH, Dumont FJ. Cyclosporin A, FK-506, and rapamycin: pharmacologie probes of lymphocyte signal transduction. Annu Rev Immunol 1992; 10:519-60.
31. + T cells by the murine B7 antigen. Eur J Immunol 1993; 23:283-6.
32. Umland SD, Lee R, Howard M, Martens C. Expression of lymphokines gene in splenic lymphocytes of autoimmune mice. Mol Immunol 1989; 26:649-56.
33. Handwerger BS. Abnormalities in interleukin-2 and interleukin-4 production in inbred Palmerston North (PN) mice. Arthritis Rheum 1989; 32:S91.
34. Hutchcroft JE, Bierer B. Activation dependent phosphorylation of T-lymphocyte surface receptor CD28 and associated proteins. Proc Natl Acad Sci USA 1994; 91:3260-4.
35. Cuadrado MJ, Marubayashi M, Ortega C et al. Relationship of IL-2, IL-2R (CD25), soluble IL-2R and IL-4 with disease activity in SLE patients. Lupus 1993; 2:257-60.
36. Linker-Israeli M. Cytokine abnormalities in human lupus. Clin Immunol Immunopathol 1992; 63:10-12.
37. Schattner A. Lymphokines in autoimmunity: a critical review. Clin Immunol Immunopathol 1994; 70:177-89.
38. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151:1224-34.
39. Willems F, Marchant A, Delville JP et al. Interlukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24:1007-9.
40. Handwerger BS. Inbred Palmerston North (PN) mice appear to have defective Th1 cell and enhanced Th2 cell function. Arthritis Rheum 1991; 34:S185.
41. Via CS, Handwerger BS. T-cell and B-cell function in lupus. Curr Opin Rheumatol 1992; 4:630-4.
42. Freedman AS, Freeman GJ, Rhynhart K, Nadler LM. Selective induction of B7/BB-1 on interferon γ stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol 1991; 137:429-37.
43. Chelen C, Fang JY, Freeman GJ et al. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. J Clin Invest 1995; 95: 1415-21.
44. Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71:1065-8.