Ikaros isoform X is selectively expressed in myeloid differentiation

Journal of Immunology

Volumn 170, Issue 6, 2003, Pages 3091-3098

  Payne, Kimberly J ^a   Huang, Grace ^a   Sahakian, Eva ^b   Zhu, Judy Y ^a   Barteneva, Natasha S ^a   Barsky, Lora W ^a   Payne, Marvin A ^b   Crooks, Gay M ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b LA SIERRA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; IKAROS TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DOWN REGULATION; GENETIC VARIABILITY; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION;

EID: 0037443411     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.6.3091     Document Type: Article

References (53)

1. Lo, K., N. R. Landau, and S. T. Smale. 1991. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol. Cell. Biol. 11:5229.
2. Georgopoulos, K., D. D. Moore, and B. Derfler. 1992. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 258:808.
3. Klug, C. A., S. J. Morrison, M. Masek, K. Hahm, S. T. Smale, and I. L. Weissman. 1998. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc. Natl. Acad. Sci. USA 95:657.
4. Nichogiannopoulou, A., M. Trevisan, S. Neben, C. Friedrich, and K. Georgopoulos. 1999. Defects in hematopoietic stem cell activity in Ikaros mutant mice. J. Exp. Med. 190:1201.
5. O'Neill, D. W., S. S. Schoetz, R. A. Lopez, M. Castle, L. Rabinowitz, E. Shor, D. Krawchuk, M. G. Goll, M. Renz, H. P. Seelig, et al. 2000. An Ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol. Cell. Biol. 20:7572.
6. Lopez, R. A., S. Schoetz, K. DeAngelis, D. O'Neill, and A. Bank. 2002. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc. Natl. Acad. Sci. USA 99:602.
7. Molnar, A., and K. Georgopoulos. 1994. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol. Cell. Biol. 14:8292.
8. Morgan, B., L. Sun, N. Avitahl, K. Andrikopoulos, T. Ikeda, E. Gonzales, P. Wu, S. Neben, and K. Georgopoulos. 1997. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16:2004.
9. Kim, J., S. Sif, B. Jones, A. Jackson, J. Koipally, E. Heller, S. Winandy, A. Viel, A. Sawyer, T. Ikeda, et al. 1999. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10:345.
10. Ito, T., S. Nomura, M. Okada, Y. Katsumata, F. Kikkawa, T. Rogi, M. Tsujimoto, and S. Mizutani. 2002. Ap-2 and Ikaros regulate transcription of human placental leucine aminopeptidase/oxytocinase gene. Biochim. Biophys. Acta 290:1048.
11. Sun, P., and H. H. Loh. 2002. Transcriptional regulation of mouse δ-opioid receptor gene: role of Ikaros in the stimulated transcription of mouse δ-opioid receptor gene in activated T cells. J. Biol. Chem. 277:12854.
12. Koipally, J., E. J. Heller, J. R. Seavitt, and K. Georgopoulos. 2002. Unconventional potentiation of gene expression by Ikaros. J. Biol. Chem. 277:13007.
13. Ernst, P., K. Hahm, and S. T. Smale. 1993. Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Mol. Cell. Biol. 13:2982.
14. Brown, K. E., S. S. Guest, S. T. Smale, K. Hahm, M. Merkenschlager, and A. G. Fisher. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91:845.
15. Koipally, J., J. Kim, B. Jones, A. Jackson, N. Avitahl, S. Winandy, M. Trevisan, A. Nichogiannopoulou, C. Kelley, and K. Georgopoulos. 1999. Ikaros chromatin remodeling complexes in the control of differentiation of the hemo-lymphoid system. Cold Spring Harbor Symp. Quant. Biol. 64:79.
16. Brown, K. E., J. Baxter, D. Graf, M. Merkenschlager, and A. G. Fisher. 1999. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell 3:207.
17. Koipally, J., and K. Georgopoulos. 2000. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J. Biol. Chem. 275:19594.
18. Cobb, B. S., S. Morales-Alcelay, G. Kleiger, K. E. Brown, A. G. Fisher, and S. T. Smale. 2000. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes Dev. 14:2146.
19. Sabbattini, P., M. Lundgren, A. Georgiou, C. Chow, G. Warnes, and N. Dillon. 2001. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J. 20:2812.
20. + thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 15:1817.
21. Dorsam, G., and E. J. Goetzl. 2002. Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. J. Biol. Chem. 277:13488.
22. Hahm, K., P. Ernst, K. Lo, G. S. Kim, C. Turck, and S. T. Smale. 1994. The lymphoid transcription factor Lyf-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14:7111.
23. Molnar, A., P. Wu, D. A. Largespada, A. Vortkamp, S. Scherer, N. G. Copeland, N. A. Jenkins, G. Bruns, and K. Georgopoulos. 1996. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J. Immunol. 156:585.
24. Sun, L., N. Heerema, L. Crotty, X. Wu, C. Navara, A. Vassilev, M. Sensel, G. H. Reaman, and F. M. Uckun. 1999. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 96:680.
25. Sun, L., M. L. Crotty, M. Sensel, H. Sather, C. Navara, J. Nachman, P. G. Steinherz, P. S. Gaynon, N. Seibel, C. Mao, et al. 1999. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Clin. Cancer Res. 5:2112.
26. Sun, L., P. A. Goodman, C. M. Wood, M. L. Crotty, M. Sensel, H. Sather, C. Navara, J. Nachman, P. G. Steinherz, P. S. Gaynon, et al. 1999. Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 17:3753.
27. Nakayama, H., F. Ishimaru, Y. Katayama, K. Nakase, N. Sezaki, K. Takenaka, K. Shinagawa, K. Ikeda, K. Niiya, and M. Harada. 2000. Ikaros expression in human hematopoietic lineages. Exp. Hematol. 28:1232.
28. Olivero, S., C. Maroc, E. Beillard, J. Gabert, W. Nietfeld, C. Chabannon, and C. Tonnelle. 2000. Detection of different Ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction. Br. J. Haematol. 110:826.
29. Payne, K. J., J. H. Nicolas, J. Y. Zhu, L. W. Barsky, and G. M. Crooks. 2001. Cutting edge: predominant expression of a novel Ikaros isoform in normal human hematopoiesis. J. Immunol. 167:1867.
30. Wang, J. H., A. Nichogiannopoulou, L. Wu, L. Sun, A. H. Sharpe, M. Bigby, and K. Georgopoulos. 1996. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 5:537.
31. Georgopoulos, K., M. Bigby, J. H. Wang, A. Molnar, P. Wu, S. Winandy, and A. Sharpe. 1994. The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143.
32. Winandy, S., L. Wu, J. H. Wang, and K. Georgopoulos. 1999. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J. Exp. Med. 190:1039.
33. Avitahl, N., S. Winandy, C. Friedrich, B. Jones, Y. Ge, and K. Georgopoulos. 1999. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 10:333.
34. Winandy, S., P. Wu, and K. Georgopoulos. 1995. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83:289.
35. Boggs, S. S., M. Trevisan, K. Patrene, and K. Georgopoulos. 1998. Lack of natural killer cell precursors in fetal liver of Ikaros knockout mutant mice. Nat. Immun. 16:137.
36. Wu, L., A. Nichogiannopoulou, K. Shortman, and K. Georgopoulos. 1997. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 7:483.
37. Dumortier, A., P. Kirstetter, P. Kastner, and S. Chan. 2002. Ikaros regulates neutrophil differentiation. Blood. 5:1336.
38. - cells in cord blood and bone marrow. Blood 86:3745.
39. - cells with both lymphoid and myeloid potential. Blood 91:4145.
40. Hao, Q. L., J. Zhu, M. A. Price, K. J. Payne, L. W. Barsky, and G. M. Crooks. 2001. Identification of a novel, human multilymphoid progenitor in cord blood. Blood 97:3683.
41. Kansas, G. S., M. J. Muirhead, and M. O. Dailey. 1990. Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans. Blood 76:2483.
42. Gooi, H. C., S. J. Thorpe, E. F. Hounsell, H. Rumpold, D. Kraft, O. Forster, and T. Feizi. 1983. Marker of peripheral blood granulocytes and monocytes of man recognized by two monoclonal antibodies VEP8 and VEP9 involves the trisaccharide 3-fucosyl-N-acetyllactosamine. Eur. J. Immunol. 13:306.
43. Davidson, S. E., J. L. McKenzie, M. E. Beard, and D. N. Hart. 1988. The tissue distribution of the 3 α-fucosyl-N-acetyl lactosamine determinant recognized by the CD15 monoclonal antibodies CMRF-7 and 27. Pathology 20:24.
44. Wright, S. D., P. S. Tobias, R. J. Ulevitch, and R. A. Ramos. 1989. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170:1231.
45. Skubitz, K., K. Micklem, and E. van der Schoot. 1995. CD66 and CD67 cluster workshop report. In Leukocyte Typing V, Vol. 1. B. L. Schlossmann, W. Gilks, J. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, T. A. Springer, T. F. Tedder, R. F. Todd, eds. Oxford Univ. Press, Oxford, p. 889.
46. Eades-Perner, A. M., J. Thompson, H. van der Putten, and W. Zimmermann. 1998. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. Blood 91:663.
47. Lian, Z., L. Wang, S. Yamaga, W. Bonds, Y. Beazer-Barclay, Y. Kluger, M. Gerstein, P. E. Newburger, N. Berliner, and S. M. Weissman. 2001. Genomic and proteomic analysis of the myeloid differentiation program. Blood 98:513.
48. Chen, G., T. G. Gharib, C. C. Huang, J. M. Taylor, D. E. Misek, S. L. Kardia, T. J. Giordano, M. D. Iannettoni, M. B. Orringer, S. M. Hanash, and D. G. Beer. 2002. Discordant protein and mRNA expression in lung adenocarcinornas. Mol. Cell. Proteomics 1:304.
49. Nakayama, H., F. Ishimaru, N. Avitahl, N. Sezaki, N. Fujii, K. Nakase, Y. Ninomiya, A. Harashima, J. Minowada, J. Tsuchiyama, et al. 1999. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. Cancer Res. 59:3931.
50. Nakase, K., F. Ishimaru, N. Avitahl, H. Dansako, K. Matsuo, K. Fujii, N. Sezaki, H. Nakayama, T. Yano, S. Fukuda, et al. 2000. Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia. Cancer Res. 60:4062.
51. Georgopoulos, K., S. Winandy, and N. Avitahl. 1997. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu. Rev. Immunol. 15:155.
52. Okano, H., Y. Saito, T. Miyazawa, T. Shinbo, D. Chou, S. Kosugi, Y. Takahashi, S. Odani, O. Niwa, and R. Kominami. 1999. Homozygous deletions and point mutations of the Ikaros gene in gamma-ray-induced mouse thymic lymphomas. Oncogene 18:6677.
53. Karlsson, A., P. Soderkvist, and S. M. Zhuang. 2002. Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas. Cancer Res. 62:2650.