Point mutations and deletions in the Znfn1a1/1karos gene in chemically induced murine lymphomas

Cancer Research

Volumn 62, Issue 9, 2002, Pages 2650-2653

  Karlsson, Anneli ^a   Söderkvist, Peter ^a   Zhuang, Shi Mei ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BUTADIENE; GENE PRODUCT; IKAROS; PHENOLPHTHALEIN; PROTEIN ZNFN1A1; UNCLASSIFIED DRUG; ZALCITABINE; ZINC FINGER PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DIMERIZATION; EXON; FRAMESHIFT MUTATION; GENE DELETION; GENE INACTIVATION; GENE INSERTION; GENE LOSS; LYMPHOMA; MISSENSE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; TRANSACTIVATION;

ALLELES; ANIMALS; BLOTTING, SOUTHERN; BUTADIENES; CARCINOGENS; DNA-BINDING PROTEINS; GENE DELETION; GENE SILENCING; IKAROS TRANSCRIPTION FACTOR; LOSS OF HETEROZYGOSITY; LYMPHOMA; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; PHENOLPHTHALEIN; POINT MUTATION; TRANSCRIPTION FACTORS; ZALCITABINE;

EID: 0036569633     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
2. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
3. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
4. The lymphoid transcription factor LyFis encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
5. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
6. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
7. The Ikaros gene is required for the development of all lymphoid lineages
8. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
9. Carcinogenicity of 1,3-butadiene in C57BL/6 X C3H F1 mice at low exposure concentrations
10. Chromosome II loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein
11. Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems
12. Allelotype analysis of 2′,3′-dideoxycytidine- and 1,3-butadieneinduced lymphomas in B6C3F1 mice
13. Homozygous deletions and point mutations of the Ikaros gene in γ-ray-induced mouse thymic lymphomas
14. Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2′,3′-dideoxycytidineinduced lymphomas
15. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
16. Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia
17. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia