Ikaros expression in human hematopoietic lineages

Experimental Hematology

Volumn 28, Issue 11, 2000, Pages 1232-1238

  Nakayama, Hiroyuki ^a   Ishimaru, Fumihiko ^a   Katayama, Yoshio ^a   Nakase, Koichi ^a   Sezaki, Nobuo ^a   Takenaka, Katsuto ^a   Shinagawa, Katsuji ^a   Ikeda, Kazuma ^a   Niiya, Kenji ^a   Harada, Mine ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Human non lymphoid lineages; Ikaros

Indexed keywords

ISOPROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BLAST CELL CRISIS; ERYTHROID CELL; GENE EXPRESSION; GRANULOCYTE; HUMAN; HUMAN CELL; IKAROS GENE; IMMUNOBLOTTING; LEUKEMIA CELL LINE; LUNG SMALL CELL CANCER; MACROPHAGE; MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

ANIMAL; CELL LINEAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; HUMAN; MICE; PROTEIN ISOFORMS; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0033792801     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(00)00530-0     Document Type: Article

References (25)

1. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
2. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
3. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
4. The Ikaros gene is required for the development of all lymphoid lineages
5. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
6. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
7. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
8. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
9. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia
10. 1-positive human cell line (BV173)
11. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia
12. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
13. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
14. A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction
15. Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus
16. - marrow progenitors
17. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors
18. Hematopoietic progenitor cells of lymphocytes and dendritic cells
19. Defects in hemopoietic stem cell activity in Ikaros mutant mice
20. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
21. An Ikaros-containing chromatin remodeling complex active in adult erythroid cells
22. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
23. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
24. Ikaros isoforms are phosphorylated in a cell-cycle dependent manner in human leukemia cell lines