Cutting edge: Predominant expression of a novel Ikaros isoform in normal human hemopoiesis

Journal of Immunology

Volumn 167, Issue 4, 2001, Pages 1867-1870

  Payne, K J ^a   Nicolas, J H ^a   Zhu, J Y ^a   Barsky, L W ^a   Crooks, G M ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IKAROS TRANSCRIPTION FACTOR; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HEMATOPOIESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; RNA SPLICING; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

EID: 0035881050     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.4.1867     Document Type: Article

References (16)

1. The role of the Ikaros gene in lymphocyte development and homeostasis
2. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
3. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
4. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
5. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
6. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
7. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding
8. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
9. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia
10. Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia
11. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
12. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
13. Detection of different Ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction
14. Ikaros expression in human hematopoietic lineages
15. - cells in cord blood and bone marrow
16. Cloning and sequencing of hIK-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1